A review. The cobalt salen mediated kinetic resolution of terminal racemic epoxides enables the generation of an extensive array of chiral epoxides, diols, amino alcs., alkyl and Ph ethers in high (>99.5%) enantiomeric excess. These chiral building blocks were further functionalized to generate a range of key intermediates which found application in the Pharmaceutical, Agrochem., Fragrance and Specialty Chem. industries. The refinement of cobalt salen catalyst technol. will be outlined, along with working examples of scaleup (ton) and downstream functionalization.