Butenafine HCl, a fungicidal agent of the benzylamine class, was applied to the skin of normal volunteers once daily for 14 consecutive days as a 1% cream formulation (Mentax'"). The doses used were approximately 2 to 20 times higher than normal therapeutic doses. Systemic exposure to butenafine was monitored by measuring levels of butenafine and selected metabolites in the plasma and urine during and after the exposure period. Plasma levels of butenafine and its M2 metabolite were low following