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项与 ASINEX Corp. 相关的药物

TT-112

靶点-

作用机制-

在研机构-

原研机构

Thrombotargets Corp.

在研适应症-

非在研适应症

出血

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

H01/TT-111

靶点-

作用机制-

在研机构-

原研机构

Thrombotargets Corp.

在研适应症-

非在研适应症

出血

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

100 项与 ASINEX Corp. 相关的临床结果

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0 项与 ASINEX Corp. 相关的专利（医药）

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1

项与 ASINEX Corp. 相关的文献（医药）

Beilstein Journal of Organic Chemistry4区 · 化学

Regio- and stereoselective synthesis of new diaminocyclopentanols

4区 · 化学

ArticleOA

作者: Larin, Evgeni A ; Kochubei, Valeri S ; Atroshchenko, Yuri M

The optimal conditions for regio- and stereoselective epoxide ring opening of N,N-disubstituted 1,2-epoxy-3-aminocyclopentanes by different nucleophilic reagents have been developed. The substituents on the nitrogen atom in the epoxide precursor and the orientation of the oxirane ring are crucial for the reaction outcome. Thus, treatment of (1RS,2SR,3SR)-1,2-epoxy-3-(N,N-dibenzylamino)cyclopentane (3b) with amines gave a mixture of C1 and C2 regioadducts, while the use of (1RS,2SR,3SR)-1,2-epoxy-3-(N-benzyl-N-methylamino)cyclopentane (3a) led ultimately to C1 adducts. Base-catalyzed aminolysis of epoxides 6a,b afforded mainly C1 adducts 13a,b arising from trans-diaxal opening of the epoxide ring. Using a Lewis acid catalyst, epoxides 6a,b were transformed into diaminocyclopentanols 14a,b via an alternative pathway involving the formation of aziridinium intermediate 17.

1

项与 ASINEX Corp. 相关的新闻（医药）

2007-05-29

·BioSpace

ASINEX Ltd. and Dompé pha.r.ma s.p.a. Announce Successful Collaboration

L'Aquila, Moscow May 28th 2007:DOMPé and ASINEX are pleased to announce a successful project which involved the rapid synthesis and purification of a large targeted orientated library of small molecules using High Throughput Chemistry (HTC) methodology.

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100 项与 ASINEX Corp. 相关的药物交易

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100 项与 ASINEX Corp. 相关的转化医学

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