US Latino adults are disproportionately affect-ed by the HIV epidemic and experiencedisparities in access to HIV care. However,relatively little is known about how accultura-tion affects perceived barriers to engagementin care among Latinos. This article examinesfactors that may be associated with engagingHIV-infected persons in primary care by usinginterview data from 651 Latino and non-Latinoadults presenting for services at five agenciesthat participated in a multisite demonstrationproject. Latinos (n5219) were more likely thannon-Latino Whites (n5117) to be male,recently diagnosed with HIV, less educated,without health insurance, not on Medicaid,taking HIV medications, and in better physicalhealth. In addition, Latinos were more likely toreport facing numerous structural barriers,stigma-related worries/concerns, and beliefbarriers than were non-Latino Whites. Uponcloser examination of the Latino subsample,acculturation (based on language) was associ-ated with reported structural barriers, worry/concern barriers, and belief barriers. In thefinal multivariate model that controlled for site,Spanish language was significantly associatedwith experiencing stigma-related worries/con-cerns that impact HIV status. (Ethn Dis.2008;18:403–408)Key Words: Latino, HIV, Stigma, Barriers,Acculturation