The objective of this study was to explore the effects of the different parity, calving season, lactation month and seasons on fat-to-protein ratio (FPR).The relevant indicators of FPR and milk composition in Holstein cow were determinedThe effects of the different parity, calving season, lactation month and seasons on FPR were analyzed.The FPR were 1.26±0.19 and different parity, lactation month and seasons have greatly significant effects on FPR (P<0.01), but calving season has no significant effect on FPR (P>0.05).The FPR in the first parity (1.23±0.17) is significantly lower than the other parities (1.32±0.2).The FPR in the first lactation is the highest, and it drops sharply from 2nd to 6th of lactation month.It's unchanged from 7th to 12th of lactation month, then falls to the lowest in the end periods of lactation (1.17±0.17).Parity, lactation month and seasons have greatly significant effects on FPR, and calving season has no significant effect on FPR.