Tech. formulation of nimesulide dispersible tablets was optimized. Using one-sided finish, hardness and dissolution of the nimesulide dispersible tablets as indicators, the optimization was performed by orthogonal design. The optimized formulation was as follow: lactose 108.8 g, sodium carboxymethyl starch 15.6 g, low substituted hydroxypropyl cellulose 13.0 g and corn starch 15.6 g. The optimized preparation formulation is stable and feasible.