Dive Brief:Mineralys Therapeutics has become the second biotechnology startup in a week to go public, raising $192 million in one of the sectors largest new stock offerings in months.Mineralys sold 12 million shares at $16 apiece, the biggestoffering by total proceeds since May 2022, according to BioPharma Dive data. The company, which is headquartered in Radnor, Penn., will begin trading under the ticker symbol MLYS on Friday on the Nasdaq stock exchange.Mineralys focus is on an experimental drug for difficult-to-treat hypertension. Called MLS-101, it was licensed from Mitsubishi Tanabe Corp. and recently met its goal in a Phase 2 trial.Dive Insight:Mineralys IPO follows closely on the heels of Structure Therapeutics $161 million offering last week.Its Nasdaq debut marks the first time two biotechs have each raised more than $100 million in IPOsin the same month since last May, a reflection of the tough funding environment young drugmakers currently face.Mineralys, like many of the companies that successfully went public in 2022, is built around one primary asset thats already in clinical testing. Amid a market downturn, investor support has grown again for single product-focused biotechs, versus platform companies that require longer runways and often greater funding.In a June 2022 analysis of more than 500 biotechs that have gone public since 2010, seven of the top 10 underperformers then were platform companies, according to consulting and research firm Bay Bridge Bio.Mineralys candidate, MLS-101, is whats known as an aldosterone synthase inhibitor. A hormone released by the kidneys, aldosterone manages blood pressure by controlling levels of sodium and potassium in the blood.Its also been the target of drugmakers for years. High levels of aldosterone are linked to uncontrolled hypertension, when extremely high blood pressure is not adequately treated by other medications.Last fall, the company read out positive data from a Phase 2 study of more than 200 patients, showing that a daily dose of MLS-101 resulted in substantial placebo-adjusted reduction in blood pressure for 24 hours.Other companies, including the recently acquired CinCor Pharma, are currently developing aldosterone synthase inhibitors, while others such as Idorsia Pharmaceuticals are testing drugs for uncontrolled hypertension that work in different ways.Mineralys raised $40 million in a Series A round in 2021, and $118 million in a Series B round in 2022. Its investors include Catalys Pacific, Samsara BioCapital, HBM Healthcare Investments, Ysios Capital and RA Capital Management. The startup is run by Jon Congleton, a former Teva Pharmaceuticals executive and previously CEO of Nivalis Therapeutics. '