In the process of synthesizing D,L-naproxen ketal, a large amount of raw material neopentyl glycol is consumed. After rearrangement and hydrolysis, a large amount of high-COD wastewater containing 2,2-dimethyl-3-bromopropanol is produced. The process of recovering neopentyl glycol by epoxidation and hydrolysis of this wastewater was studied, and the production cost was reduced, and the recycling economy was developed to help environmental protection.