We had optimized the synthesis of citalopram hydrobromide tech. solution to 5-cyano phthalide as raw material, the use of "one pot" method and two-step Grignard reaction, after hydrolysis, closed loop, salt formation, and ultimately to give hydrobromide citalopram.The improved synthesis of mild reaction conditions, was simple operation, high yield, low impurity content of products, suitable for industrial production