The novel route for the direct transformation of aromatic alkyl ketones RC6H4C(O)CH2R1 (R = 2-MeO, 3-Cl, 4-BuO; R1 = H, Me, Ph) into 5-aryl-6H-1,3,4-thiadiazine-2-amines I provides moderate to excellent yields while employing readily available reagents under mild reaction conditions has been described.