Since the rise of the SARS-CoV-2 pandemic in the winter of 2019, the need for an affordable and efficient drug has not yet been met. Leveraging its unique, fast and precise binding free energy prediction technol., Aqemia screened and ranked FDA-approved mols. against the 3ClPro protein. This protease is key to the post-translational modification of two polyproteins produced by the viral genome. We propose in our top 10 predicted mols. some drugs or prodrugs that could be repurposed and used in the treatment of COVID cases.