Nuwacell Biotechnologies Co., Ltd.

The target of this trial is to evaluate the safety, tolerability and preliminary efficacy of NCR101 in the treatment of subjects with interstitial lung disease. The trial contains Single ascending dose（SAD） and Multiple ascending dose（MAD）. Subjects will receive at least 1 dose of NCR101.

This clinical study is to investigate the safety and efficacy of NCR100 injection in subjects with knee osteoarthritis (KOA). It contains two parts dose-escalating, and blind random study in adult KOA subjects.

主要目的： Ⅰb期：评价NCR100注射液在膝骨关节炎患者中多次给药的安全性和耐受性；确定Ⅱ期研究中NCR100注射液的治疗剂量。 次要目的： Ⅰb期：评价NCR100注射液在膝骨关节炎患者中多次给药后的初步有效性；探索NCR100注射液治疗后生物标志物变化。