A methodol. for the determination of betamethasone tablet content and homogeneity was studied.An interference by excipients was observed in the spectrophotometric method because of UV absorption at the detection wavelength, and the long duration pretreatment-induced error in homogeneity determinationA HPLC method with 60% MeOH ultrasound extraction for 5 min., and as the solvent, the pretreatment was simplified and the results were satisfactory.Using the Whatman Partisphere C18 column with MeOH-H2O (60:40) as the mobile phase, a flow rate of 1.0 mL/min. and detection wavelength of 240 nm, and temperature 20°, the linear range was shown to be 8-40 μg/mL, and the recovery and RSD being 100.8% and 0.8%, resp.