Abstract:Solid lipid nanoparticles (SLNs) are gaining significant attention in the pharmaceutical
industry due to their biocompatibility and biodegradability, making them a popular functional
nanocarrier. SLNs are a popular nanocarrier due to their ability to bypass the spleen and liver, offer
high drug stability, and improve bioavailability, sterilization, immobilization, targeted drug release,
and biocompatible ingredients. This article discusses various SLN preparation techniques, including
high shear homogenization, hot homogenization, cold homogenization, microemulsion-based, solvent
evaporation, solvent emulsification-evaporation, supercritical fluid-based, spray drying, double
emulsion, and precipitation techniques, focusing on methodological aspects. This review discusses
the physicochemical behavior of SLNs, including drug loading, release, particle size, stability, cytotoxicity,
and cellular uptake, and their major biomedical applications.