HPLC for chlorogenic acid and baicalin levels detection in Qingkailing was established.The separation was carried out on a phenomenex C18 column (250 mm×4.6 mm, 5 μm), with methanol (A)-0.8% acetic acid (B) as mobile phase (0 min, A:B=20:80, and 10 min, A:B=80:20).The flow rate was 1.0 mL/min and detection wavelength was 324 nm.The mean recovery of chlorogenic acid and baicalin was 100.7% and 99.6%, with RSD 2.2% and 1.8%, resp.The linear range of chlorogenic acid and baicalin was 0.024-0.594 μg and 0.253-2.02 μg, resp.This method is simple, fast and accurate and available for the quality control of Qingkailing.