PURCHASE, N.Y., Sept. 07, 2023 (GLOBE NEWSWIRE) -- Cognition Therapeutics, Inc., (Nasdaq: CGTX), (the “Company” or “Cognition”) has released its sixth “Conversations” video podcast, which features an interactive discussion with retinal specialists about dry age-related macular degeneration (dry AMD)AMD) and the current treatment landscape. Dry AMDAMD is caused by a degeneration of the macula and gradual loss of central vision. An estimated 1.5 million people in the United States are affected by late-stage dry AMDAMD, which can result in permanent vision loss. C. Gustavo De Moraes, M.D., Ph.D., MPH, associate professor of clinical ophthalmology at Columbia University and chief medical officer of Ora, a CRO focused on ophthalmology, moderates this discussion of the pathologic drivers of dry AMDAMD, the treatment landscape, clinical rationale for sigma-2 (σ-2) receptor modulatorssigma-2 (σ-2) receptor modulators and the ongoing MAGNIFY phase 2 trial of CT1812 in geographic atrophy secondary to dry AMDAMD. Panelists include Anthony Caggiano, M.D., Ph.D., Cognition Therapeutics’ chief medical officer and two leading industry experts on research and treatment of retinal disease. Jeffrey S. Heier, M.D., Director of the Vitreoretinal Service & Retina Research at Ophthalmic Consultants of Boston Cognition Therapeutics welcomes comments, questions and feedback on this and other Conversations episodes which may be submitted at conversations@cogrx.com. We’d love to hear your thoughts. CT1812 is an experimental orally delivered small molecule sigma-2 (σ-2) receptor modulatorsigma-2 (σ-2) receptor modulator designed to penetrate the blood-retinal barrier and bind selectively and saturably to the σ-2 receptor complex. The σ-2 receptor complex is involved in the regulation of key cellular processes such as membrane trafficking and autophagy that are damaged by toxic interaction with soluble beta amyloid (Aβ) oligomers, oxidative stress and other stressors. Cognition’s clinical program will assess if regulating these processes by modulating the σ-2 receptor with CT1812 can maintain homeostatic function. Dry AMD, one of two forms of AMD, is common among people over 50 and is caused by degeneration and thinning of the macula, the part of the retina responsible for central vision. The gradual loss of central vision associated with dry AMD can present limitations in reading and driving. As the disease progresses in severity into geographic atrophy, degeneration of retinal pigment epithelial (RPE) cells can result in permanent vision loss. Our podcast series does not constitute the practice of medical advice, diagnosis or treatment. Always talk to your health care provider for diagnosis and treatment, including your specific medical needs. If you have or suspect that you have a medical problem or condition, please contact a qualified health care professional immediately.
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Tiberend Strategic Advisors, Inc.
Daniel Kontoh-Boateng (investors)
Tiberend Strategic Advisors, Inc.