Encouraging antitumor activity in heavily pretreated population during dose finding
Well tolerated across broad dose range in phase 1 first-in-human study
Poster Presentation at ASCO on June 3, 8:00-11:00 a.m. CT LOS ANGELES, CA, USA I June 1, 2023 I TORL BioTherapeutics LLC ("TORL Bio" or "the Company") announces the initial results from an ongoing phase I study of their claudin 6 (CLDN6) targeted antibody drug conjugate (ADC), TORL-1-23, in patients with advanced cancer on the American Society of Oncology (ASCO) website : https://meetings.asco.org/meetings/2023-asco-annual-meeting/299/program-guide/scheduled-sessions#date-6/3/2023. The poster presentation (ASCO Abstract 3082) of the TORL123-001 (TRIO-049) trial will include updated data through the 2.4mg/kg dose level and will be presented by the Global Principal Investigator, Dr. Gottfried Konecny of the University of California Los Angeles (UCLA) Medical Center. Twenty-five (25) patients with heavily pretreated (an average of 5 prior lines of therapy) metastatic ovarian (n=19), testicular (n=3), and endometrial (n=3) cancers were enrolled and evaluable for safety and efficacy across 8 dose levels ranging from 0.2 to 2.4 mg/kg IV every 3 weeks. "We are excited to provide the first clinical data with TORL-1-23, a novel claudin 6 targeted ADC" stated Dave Licata, CEO and Co-Founder of TORL Bio. "We are very encouraged by the current TORL-1-23 efficacy and safety data indicating that this drug could represent a new potential treatment for patients with ovarian and other CLDN6+ cancers" said Dennis Slamon, MD, PhD, and Co-Founder of TORL Bio. Key study findings include:
Poster Presentation Details:
Title: Initial results of dose finding in a first-in-human phase I study of a novel Claudin 6 (CLDN6) targeted antibody drug conjugate (ADC) TORL-1-23 in patients with advanced solid tumors. Lead author: Gottfried E. Konecny, M.D, University of California Los Angeles Medical Center, Los Angeles, CA
Session Title: Developmental Therapeutics-Molecularly Targeted Agents and Tumor Biology Session Date and Time: June 3, 2023, 8:00-11:00 a.m. CT
https://meetings.asco.org/meetings/2023-asco-annual-meeting/299/program-guide/scheduled-sessions#date-6/3/2023
About TORL123-001 (TRIO-049) Clinical Study
TORL BioTherapeutics is currently enrolling patients in a phase I study, TORL123-001 (TRIO-049), to assess the safety, pharmacokinetics, biomarkers, and antitumor activity of TORL-1-23. Further details including current study sites can be found at https://clinicaltrials.gov/show/NCT05103683 TORL BioTherapeutics, LLC is a clinical-stage biopharmaceutical company developing novel, antibody-based therapeutics with the goal of transforming the lives of patients with cancer. Through a strategic partnership with the Slamon Research Lab at UCLA, TORL Bio has exclusive development and commercial rights to biologics-based drug candidates focused on promising cancer targets. The lead program, TORL-1-23, is a CLDN6-directed ADC developed for patients across multiple cancer types. The Company also has two other clinical-stage programs; an ADC and mAb targeting claudin 18.2 (CLDN 18.2). TORL Bio is further developing a broad pipeline of novel preclinical ADCs and mAb in oncologic indications having a high unmet medical need. TORL Bio is headquartered in Los Angeles, California.