CB-PIC(CB-PIC) - 药物靶点：Akt x STAT3 x p38 MAPK_在研适应症：肿瘤_专利_临床

概要

基本信息

药物类型

小分子化药

别名

(E)-4-((2-(3-oxopop-1-enyl)phenoxy)methyl)pyridinium malonic acid

靶点

Akt x STAT3 x p38 MAPK

作用机制

Akt 抑制剂(原癌基因蛋白c-akt 抑制剂)、STAT3抑制剂(信号转导和转录激活因子-3抑制剂)、p38 MAPK抑制剂(P38丝裂原活化蛋白激酶抑制剂)

治疗领域

肿瘤

在研适应症

肿瘤

非在研适应症-

原研机构

Kyung Hee University

在研机构

Kyung Hee University

非在研机构-

最高研发阶段药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 CB-PIC 相关的临床结果

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100 项与 CB-PIC 相关的转化医学

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100 项与 CB-PIC 相关的专利（医药）

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1

项与 CB-PIC 相关的文献（医药）

1994-09-01·Acta Neurochirurgica3区 · 医学

Pretreatment with a competitive NMDA antagonist D-CPPene attenuates focal cerebral infarction and brain swelling in awake rats

3区 · 医学

Article

作者: J. K. Kang ; C. R. Choi ; C. K. Park ; J. McCulloch

The purpose of the study was to assess effects of the competitive N-methyl-D-aspartate (NMDA) receptor antagonist D-(E)-4-(3-phosphonoprop-2-enyl)piperazine-2-carboxylic acid (D-CPPene) upon focal cerebral infarction and brain oedema in the rat. Focal cerebral ischaemia was produced by permanent occlusion of the middle cerebral artery under halothane anaesthesia. The anaesthetic gas was discontinued immediately after the occlusion and the rats were killed 24 hours later. Cerebral infarction and brain swelling were each assessed on the frozen brain sections at 8 predetermined coronal planes. Pretreatment with D-CPPene (4.5 mg/kg i.v. followed by continuous infusion at 3 mg/kg/h until sacrifice) 15 minutes prior to MCA occlusion, significantly reduced the volume of infarction in the cerebral hemisphere by 29% (p < 0.05). Brain swelling, obtained by subtracting the nonischaemic hemispheric volume from the ischaemic hemispheric volume, was significantly reduced with D-CPPene treatment and the mean reduction in swelling (34% less than the controls: p < 0.001) proportionately similar to the decrease in infarct volume in the same animals. These data indicate that systemic administration of the competitive NMDA receptor antagonist D-CPPene has neuroprotective effects against ischaemic brain damage, and the reduction in brain swelling occurs in parallel with the reduction in ischaemic damage.

100 项与 CB-PIC 相关的药物交易

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