CVL 354

Reports Third-Quarter Diluted EPS of $0.88 on a GAAP Basis, a Decrease of 12.0 Percent; Adjusted Diluted EPS of $3.00, an Increase of 1.7 Percent; These Results Include an Unfavorable Impact of $0.04 Per Share Related to Acquired IPR&D and Milestones Expense Delivers Third-Quarter Net Revenues of $14.460 Billion, an Increase of 3.8 Percent on a Reported Basis or 4.9 Percent on an Operational Basis Third-Quarter Global Net Revenues from the Immunology Portfolio Were $7.046 Billion, an Increase of 3.9 Percent on a Reported Basis, or 4.8 Percent on an Operational Basis; Global Humira Net Revenues Were $2.227 Billion; Global Skyrizi Net Revenues Were $3.205 Billion; Global Rinvoq Net Revenues Were $1.614 Billion Third-Quarter Global Net Revenues from the Oncology Portfolio Were $1.687 Billion, an Increase of 11.6 Percent on a Reported Basis, or 13.0 Percent on an Operational Basis; Global Imbruvica Net Revenues Were $828 Million; Global Venclexta Net Revenues Were $677 Million Third-Quarter Global Net Revenues from the Neuroscience Portfolio Were $2.363 Billion, an Increase of 15.6 Percent on a Reported Basis, or 16.0 Percent on an Operational Basis; Global Botox Therapeutic Net Revenues Were $848 Million; Global Vraylar Net Revenues Were $875 Million; Combined Global Ubrelvy and Qulipta Net Revenues Were $445 Million Third-Quarter Global Net Revenues from the Aesthetics Portfolio Were $1.239 Billion, a Decrease of 0.1 Percent on a Reported Basis, or an Increase of 1.8 Percent on an Operational Basis; Global Botox Cosmetic Net Revenues Were $671 Million; Global Juvederm Net Revenues Were $258 Million Successfully Completed Acquisition of Cerevel, Adding Pipeline of Highly Complementary Assets to AbbVie's Existing Neuroscience Portfolio Raises 2024 Adjusted Diluted EPS Guidance Range from $10.67 - $10.87 to $10.90 - $10.94, which Includes an Unfavorable Impact of $0.64 Per Share Related to Acquired IPR&D and Milestones Expense Incurred Year-To-Date Through the Third Quarter 2024 Announces 2025 Dividend Increase of 5.8 Percent, Beginning with Dividend Payable in February 2025 NORTH CHICAGO, Ill., Oct. 30, 2024 /PRNewswire/ -- AbbVie (NYSE:ABBV) announced financial results for the third quarter ended September 30, 2024. "We delivered another quarter of strong commercial execution and significant pipeline progress," said Robert A. Michael, chief executive officer, AbbVie. "Based upon the momentum of AbbVie's business and our confidence in the long-term growth outlook, we are once again raising our full-year guidance and are increasing our quarterly dividend." Third -Quarter Results Worldwide net revenues were $14.460 billion, an increase of 3.8 percent on a reported basis, or 4.9 percent on an operational basis. Global net revenues from the immunology portfolio were $7.046 billion, an increase of 3.9 percent on a reported basis, or 4.8 percent on an operational basis. Global Humira net revenues of $2.227 billion decreased 37.2 percent on a reported basis, or 36.5 percent on an operational basis. U.S. Humira net revenues were $1.765 billion, a decrease of 41.6 percent. Internationally, Humira net revenues were $462 million, a decrease of 12.4 percent on a reported basis, or 7.8 percent on an operational basis. Global Skyrizi net revenues were $3.205 billion, an increase of 50.8 percent on a reported basis, or 51.5 percent on an operational basis. Global Rinvoq net revenues were $1.614 billion, an increase of 45.3 percent on a reported basis, or 47.4 percent on an operational basis. Global net revenues from the oncology portfolio were $1.687 billion, an increase of 11.6 percent on a reported basis, or 13.0 percent on an operational basis. Global Imbruvica net revenues were $828 million, a decrease of 8.8 percent, with U.S. net revenues of $618 million and international profit sharing of $210 million. Global Venclexta net revenues were $677 million, an increase of 14.8 percent on a reported basis, or 18.2 percent on an operational basis. Global Elahere net revenues were $139 million. Global net revenues from the neuroscience portfolio were $2.363 billion, an increase of 15.6 percent on a reported basis, or 16.0 percent on an operational basis. Global Botox Therapeutic net revenues were $848 million, an increase of 13.4 percent on a reported basis, or 14.4 percent on an operational basis. Global Vraylar net revenues were $875 million, an increase of 16.6 percent. Global Ubrelvy net revenues were $269 million, an increase of 15.3 percent. Global Qulipta net revenues were $176 million, an increase of 33.6 percent. Global net revenues from the aesthetics portfolio were $1.239 billion, a decrease of 0.1 percent on a reported basis, or an increase of 1.8 percent on an operational basis. Global Botox Cosmetic net revenues were $671 million, an increase of 8.2 percent on a reported basis, or 9.9 percent on an operational basis. Global Juvederm net revenues were $258 million, a decrease of 19.7 percent on a reported basis, or 16.9 percent on an operational basis. On a GAAP basis, the gross margin ratio in the third quarter was 70.9 percent. The adjusted gross margin ratio was 84.4 percent. On a GAAP basis, selling, general and administrative (SG&A) expense was 29.1 percent of net revenues. The adjusted SG&A expense was 23.0 percent of net revenues. On a GAAP basis, research and development (R&D) expense was 14.7 percent of net revenues. The adjusted R&D expense was 14.2 percent of net revenues. Acquired IPR&D and milestones expense was 0.6 percent of net revenues. On a GAAP basis, the operating margin in the third quarter was 26.5 percent. The adjusted operating margin was 46.7 percent. Net interest expense was $591 million. On a GAAP basis, the tax rate in the quarter was 25.0 percent. The adjusted tax rate was 16.2 percent. Diluted EPS in the third quarter was $0.88 on a GAAP basis. Adjusted diluted EPS, excluding specified items, was $3.00. These results include an unfavorable impact of $0.04 per share related to acquired IPR&D and milestones expense. Note: "Operational" comparisons are presented at constant currency rates that reflect comparative local currency net revenues at the prior year's foreign exchange rates. Recent Events AbbVie announced that it completed its acquisition of Cerevel, adding a pipeline of highly complementary assets to AbbVie's existing neuroscience portfolio. Cerevel's pipeline includes emraclidine, a potential best-in-class, next-generation antipsychotic, that is being studied for the treatment of schizophrenia; tavapadon, a first-in-class dopamine D1/D5 selective partial agonist for the management of Parkinson's disease (PD); as well as CVL-354, a potential best-in-class kappa opioid receptor (KOR) antagonist being studied for the treatment of major depressive disorder (MDD). Cerevel is a strong strategic fit for AbbVie and has potential to meaningfully impact revenue into the next decade. AbbVie announced positive topline results from its pivotal Phase 3 TEMPO-1 trial evaluating tavapadon as a fixed-dose monotherapy treatment in early PD. In the study, tavapadon met the primary endpoint, demonstrating a statistically significant improvement from baseline in the Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Parts II and III combined score at week 26. Tavapadon also met the key secondary endpoint, demonstrating statistically significant improvement from baseline in the MDS-UPDRS Part II score. Full results from the TEMPO-1 study will be submitted for presentation at future medical meetings and used to support regulatory submissions of tavapadon as a treatment for PD. Topline results from TEMPO-2, the Phase 3 flexible-dose monotherapy trial for tavapadon, are expected by the end of 2024. AbbVie announced the U.S. Food and Drug Administration (FDA) approved Vyalev (foscarbidopa and foslevodopa) as the first subcutaneous 24-hour infusion of levodopa-based therapy for the treatment of motor fluctuations in adults with advanced PD. The approval was supported by results from a pivotal Phase 3 head-to-head, randomized and controlled clinical trial that demonstrated a statistically significant improvement in "on" time without troublesome dyskinesia and decreased "off" time, compared to oral immediate-release carbidopa/levodopa (CD/LD). AbbVie and Aliada Therapeutics announced a definitive agreement under which AbbVie will acquire Aliada, a biotechnology company advancing therapies using a novel blood-brain barrier (BBB)-crossing technology to address challenging central nervous system (CNS) diseases. Aliada's lead investigational asset utilizing this delivery technology, ALIA-1758, is an anti-pyroglutamate amyloid beta (3pE-Aβ) antibody in development for the treatment of Alzheimer's disease (AD). The acquisition also allows AbbVie to utilize Aliada's novel BBB-crossing technology to enhance discovery and development efforts across neuroscience. AbbVie and Gedeon Richter announced a new discovery, co-development and license agreement to advance novel targets for the potential treatment of neuropsychiatric conditions. This collaboration expands upon the success of nearly two decades of partnership on CNS projects. AbbVie announced the European Commission (EC) approved Skyrizi (risankizumab) for the treatment of adult patients with moderately to severely active ulcerative colitis (UC) who have had an inadequate response, lost response, or were intolerant to conventional or biologic therapy. The approval was supported by data from two pivotal Phase 3 trials in which Skyrizi achieved the primary endpoint of clinical remission as well as key secondary endpoints. This marketing authorization for Skyrizi marks its fourth approved indication in the European Union (EU). Skyrizi is part of a collaboration between Boehringer Ingelheim and AbbVie, with AbbVie leading development and commercialization globally. At the European Academy of Dermatology and Venerology (EADV) Congress 2024, AbbVie shared more than 30 presentations that showcased the depth and strength of AbbVie's dermatology portfolio. Presentations highlighted data for Rinvoq (upadacitinib), Skyrizi and lutikizumab across a multitude of dermatological conditions. AbbVie announced that the EC granted conditional marketing authorization for Tepkinly (epcoritamab) as a monotherapy for the treatment of adult patients with relapsed or refractory (r/r) follicular lymphoma (FL) after two or more lines of prior therapy. Tepkinly is the first subcutaneous bispecific antibody conditionally approved as a monotherapy in the EU to treat both r/r FL and r/r diffuse large B-cell lymphoma (DLBCL), after two or more lines of prior therapy. The EC approval is supported by data from the Phase 1/2 EPCORE NHL-1 clinical trial, which evaluated the safety and efficacy of Tepkinly in adult patients with r/r FL. Tepkinly is being co-developed by AbbVie and Genmab. AbbVie announced the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion recommending the marketing authorization of Elahere (mirvetuximab soravtansine) for the treatment of adult patients with folate receptor alpha (FRα)-positive, platinum-resistant and high-grade serous epithelial ovarian, fallopian tube or primary peritoneal cancer who have received one to three prior treatment regimens. The CHMP's opinion is supported by results of the Phase 3 MIRASOL clinical trial and the EC decision on this indication for Elahere is anticipated later this year. AbbVie announced submission of a Biologics License Application (BLA) to the FDA for accelerated approval (AA) of Teliso-V (telisotuzumab vedotin) in adult patients with previously treated, locally advanced or metastatic epidermal growth factor receptor (EGFR) wild type, nonsquamous non-small cell lung cancer (NSCLC) with c-Met protein overexpression. The BLA is supported by data from the Phase 2 LUMINOSITY clinical trial and review of the BLA will be conducted under FDA's Oncology Center of Excellence (OCE) Real-Time Oncology Review (RTOR) program. There are currently no approved anti-cancer therapies specifically for c-Met overexpressing NSCLC and if approved, Teliso-V would be the first-in-class therapy for this patient population. At the European Society for Medical Oncology (ESMO) Congress 2024, AbbVie showcased new data from its innovative antibody-drug conjugate (ADC) platform in tumor types with high unmet needs. Highlights included full data from the primary analysis of the positive, single-arm Phase 2 PICCOLO trial, evaluating Elahere for high FRα expressing platinum-sensitive ovarian cancer (PSOC); patient reported outcomes from the Phase 2 LUMINOSITY trial, evaluating Teliso-V in advanced NSCLC; as well as new safety and efficacy data in pre-treated patients with advanced NSCLC and gastroesophageal (GEA) cancer, from a Phase 1 study of ABBV-400 (telisotuzumab adizutecan). Allergan Aesthetics announced the FDA approved Botox Cosmetic (onabotulinumtoxinA) for temporary improvement in the appearance of moderate to severe vertical bands connecting the jaw and neck (platysma bands) in adults. Botox Cosmetic is the first product with four aesthetic indication areas: forehead lines, frown lines, crow's feet lines, and now platysma bands, making it the first product of its kind to go beyond the face. Allergan Aesthetics announced the launch of Botox Cosmetic for the treatment of masseter muscle prominence (MMP) in China. The approval is supported by Botox Cosmetic's well-established safety profile as well as clinical trial data that demonstrated Botox Cosmetic is effective in reducing the prominence of the masseter muscle. Botox Cosmetic is the first neurotoxin approved in China for MMP, the largest global MMP market. Allergan Aesthetics intends to develop Botox Cosmetic treatment for MMP in additional global markets and expand the use of Botox Cosmetic in the lower face. At the American Society for Dermal Surgery (ASDS), Allergan Aesthetics presented a total of 12 abstracts that showcased its commitment to patient outcomes and detailed insights and understanding of key concerns across differentiated patient segments. Highlights included four Best of Cosmetic Abstracts as well as a panel discussion on the impact of social media on patient experience and expectations when considering aesthetic treatment. Full-Year 2024 Outlook AbbVie is raising its adjusted diluted EPS guidance for the full year 2024 from $10.67 - $10.87 to $10.90 - $10.94, which includes an unfavorable impact of $0.64 per share related to acquired IPR&D and milestones expense incurred year-to-date through the third quarter 2024. The company's 2024 adjusted diluted EPS guidance excludes any impact from acquired IPR&D and milestones that may be incurred beyond the third quarter of 2024, as both cannot be reliably forecasted. Any potential IPR&D and milestones expense related to the recently announced acquisition of Aliada Therapeutics is also excluded from AbbVie's 2024 adjusted diluted EPS guidance, as the transaction is expected to close in the fourth quarter of 2024. Company Declares Dividend Increase of 5.8 Percent AbbVie is announcing today that its board of directors declared an increase in the company's quarterly cash dividend from $1.55 per share to $1.64 per share beginning with the dividend payable on February 14, 2025 to shareholders of record as of January 15, 2025. This reflects an increase of approximately 5.8 percent, continuing AbbVie's strong commitment to returning cash to shareholders through a growing dividend. Since the company's inception in 2013, AbbVie has increased its quarterly dividend by 310 percent. AbbVie is a member of the S&P Dividend Aristocrats Index, which tracks companies that have annually increased their dividend for at least 25 consecutive years. About AbbVie AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience and eye care - and products and services across our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on X (formerly Twitter), Facebook, Instagram, YouTube or LinkedIn. Conference Call AbbVie will host an investor conference call today at 8:00 a.m. Central Time to discuss our third-quarter performance. The call will be webcast through AbbVie's Investor Relations website at investors.abbvie.com. An archived edition of the call will be available after 11:00 a.m. Central Time. Non-GAAP Financial Results Financial results for 2024 and 2023 are presented on both a reported and a non-GAAP basis. Reported results were prepared in accordance with GAAP and include all revenue and expenses recognized during the period. Non-GAAP results adjust for certain non-cash items and for factors that are unusual or unpredictable, and exclude those costs, expenses, and other specified items presented in the reconciliation tables later in this release. AbbVie's management believes non-GAAP financial measures provide useful information to investors regarding AbbVie's results of operations and assist management, analysts, and investors in evaluating the performance of the business. Non-GAAP financial measures should be considered in addition to, and not as a substitute for, measures of financial performance prepared in accordance with GAAP. Forward-Looking Statements Some statements in this news release are, or may be considered, forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995. The words "believe," "expect," "anticipate," "project" and similar expressions and uses of future or conditional verbs, generally identify forward-looking statements. AbbVie cautions that these forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially from those expressed or implied in the forward-looking statements. Such risks and uncertainties include, but are not limited to, challenges to intellectual property, competition from other products, difficulties inherent in the research and development process, adverse litigation or government action, and changes to laws and regulations applicable to our industry. Additional information about the economic, competitive, governmental, technological and other factors that may affect AbbVie's operations is set forth in Item 1A, "Risk Factors," of AbbVie's 2023 Annual Report on Form 10-K, which has been filed with the Securities and Exchange Commission, as updated by its Quarterly Reports on Form 10-Q and in other documents that AbbVie subsequently files with the Securities and Exchange Commission that update, supplement or supersede such information. AbbVie undertakes no obligation, and specifically declines, to release publicly any revisions to forward-looking statements as a result of subsequent events or developments, except as required by law. SOURCE AbbVie WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

药械追踪 No.1 / 艾尔建美学第7款玻尿酸在中国正式获批上市 近日，艾尔建美学旗下的“含利多卡因注射用交联透明质酸钠凝胶”乔雅登越致正式获国家药监局批准，主要用于注射到面部真皮组织的中层至深层部位，以纠正重度鼻唇沟皱纹。 截止目前，艾尔建美学的乔雅登家族共有7款产品国内获批，按照交联技术的不同，产品分别U系列和V系列，其中，采用Hylacross技术的U系列有3款，分别为雅致Ultra、极致Ultra Plus和越致；采用Vycross技术的V系列有4款，分别为丰颜Voluma、缇颜Volift、质颜Volbella和朔颜Volux，系列产品适应证涵盖面颊部、鼻唇沟、唇部、鼻部、下颌轮廓多个部位的治疗。 艾尔建美学作为一家艾伯维旗下的公司，致力于研发、生产和销售一系列先进的美学品牌和产品，其医美业务板块主要涵盖肉毒素、透明质酸填充剂、美胸产品、身体塑性和功能性护肤产品等领域。艾尔建美学的前身为艾尔建，总部位于爱尔兰都柏林，2009年艾尔建正式进入中国市场，总部位于上海，2020年5月8日，美国艾伯维Abbvie以640.84亿美元已经完成对艾尔建Allergan的收购，正式更名为艾尔建美学。 ->点击阅读原文，解锁完整双语新闻 No.2 / 罗氏阿尔茨海默病诊断试剂盒在海南获批上市 近日，罗氏诊断阿尔茨海默病脑脊液系列试剂盒（包括Elecsys β-Amyloid (1-42) CSF II、Elecsys Phospho-Tau (181P) CSF、Elecsys Total-Tau CSF检测试剂，以及适配的定标液、质控品等在内的9个产品）正式获得海南省药品监督管理局批准，即将落地上海交通大学医学院附属瑞金海南医院（海南博鳌研究型医院）。 作为进口临床急需医疗器械，该试剂盒是国内首款获批的阿尔茨海默病脑脊液检测试剂盒，可定量测定人脑脊液中的β-淀粉样蛋白（1-42）（Aβ-42）、磷酸化Tau蛋白（P-Tau）和总Tau蛋白（T-Tau）的浓度，用于评估阿尔茨海默病及其他原因所引起的认知障碍，也可以辅助鉴别认知衰退风险较低和较高的患者。 ->点击阅读原文，解锁完整双语新闻 企业动态 No.1 /协和麒麟亚太地区精简和重组：出售中国大陆业务 日本协和麒麟（东京证券交易所代码：4151）近日宣布其亚太地区业务战略发生重大转变。该公司将完全退出中国大陆市场，同时将其在亚太其他地区的大部分产品组合商业化授权给合作伙伴公司，仅保留少数核心全球品牌的权利。此次重组也影响了协和麒麟的研发布局，另一份新闻稿显示，该公司计划从小分子研究转向抗体和造血干细胞基因治疗（HSC-GT）。 ▶中国业务交给维健医药 协和麒麟将彻底关闭协和麒麟（中国）制药有限公司，将该公司在中国的产品组合（包括五个已建立的品牌）转让给一家特殊目的公司，然后将股权转让给香港维健医药，交易价格为7.2亿元人民币（约1亿美元）。协和麒麟还将其全球产品麟平（布罗索尤单抗）和惠尔金（莫格利珠单抗）在中国的商业权交给维健医药。 GBI数据显示，协和麒麟的中国业务包括12种产品，其中，麟平于2021年在中国获得批准，惠尔金于2022年获得批准。其产品组合在2023、2022和2021年的销售额分别为5.89亿元人民币（8100万美元）、5.44亿元人民币和7.61亿元人民币。 ▶大昌华嘉获得亚太地区授权 同时，协和麒麟还将把其成熟产品组合在中国香港/澳门、韩国、马来西亚、新加坡、中国台湾和泰国的商业化权利授予香港的大昌华嘉 。大昌华嘉还将负责在中国香港/澳门、马来西亚、新加坡和泰国商业化麟平；在新加坡商业化惠尔金。 这就意味着，协和麒麟在出售其中国大陆业务的同时，正在同步清盘其在中国香港、泰国、马来西亚和新加坡的现有业务。后续该公司将在韩国、中国台湾和澳大利亚市场自主开发两种全球产品（麟平和惠尔金）。 ▶研发重组 另一份公告显示，协和麒麟还计划将研发重点放在骨骼和矿物质、血液癌症/难治性血液疾病和罕见疾病上。这意味着该公司将只专注于开发先进的抗体技术和造血干细胞基因治疗。小分子药物自主研发活动以及相关的生产、CMC研究和质量相关活动将逐步取消，并为受影响的员工启动自愿退休计划。 根据协和麒麟的公告，该公司进行重组是确保其可持续发展的必要举措，同时“考虑到外部环境变化”，而且首席国际业务官Abdul Mullick博士强调了“亚太地区日益严峻的挑战”。值得注意的是，去年协和麒麟还决定通过与德国Grünenthal GmbH设立的合资企业（后者持有51%股份）出售其在欧洲的产品组合。 ->点击阅读原文，解锁完整双语新闻 No.2 /菲鹏制药在印尼投资建厂 菲鹏制药在印度尼西亚西爪哇投资了一家新的生产工厂。菲鹏制药在印度尼西亚拥有子公司PT Fapon Bioindustries Indonesia。 菲鹏制药专注于为体外诊断企业提供试剂核心原料、试剂解决方案、开放仪器平台等多元化产品与服务；其印尼工厂则专注于向当地市场推出最新的体外诊断（IVD）产品。 ->点击阅读原文，解锁完整双语新闻 No.3 /87亿美元！艾伯维收购神经科学公司Cerevel 艾伯维（纽约证券交易所：ABBV）近日宣布完成对马萨诸塞州剑桥生物技术公司Cerevel Therapeutics（纳斯达克：CERE）的收购。 艾伯维以每股 45.00 美元的现金收购 Cerevel 的所有流通股；总股权价值约为 87 亿美元。值得注意的是，该交易于2023年12月首次宣布，但因今年2月美国联邦贸易委员会（FTC）第二次要求提供有关反垄断问题的信息而推迟。 艾伯维表示，通过此次交易，可以获得Cerevel潜在同类最佳的精神病和神经系统疾病药物，针对精神分裂症、帕金森病和情绪障碍等特定适应证。这些药物正处于临床阶段，与艾伯维现有的产品组合高度互补。 艾伯维选择了Cerevel的四种候选药物： ▶Emraclidine是一种毒蕈碱 M4 受体的正变构调节剂 （PAM），会刺激一种有助于控制乙酰胆碱释放的蛋白质。目前处于用于治疗精神分裂症成人患者的II期临床试验。 ▶ Tavapadon是一款选择性靶向多巴胺D1/D5受体亚型的部分激动剂，每日一次口服治疗帕金森病（PD），正在进行单药及辅助治疗的III期临床试验。该药一项关键III期临床试验最近达到了主要终点，更完整的数据将于今年晚些时候公布。 ▶CVL-354是一种kappa型阿片受体（KOR）拮抗剂，目前处于I期临床阶段。与现有重度抑郁症 （MDD）疗法比，CVL-354有潜力显著提高疗效和耐受性。 ▶Darigabat是一种 α2/3/5 选择性 GABAA 受体 PAM，用于治疗难治性癫痫和恐慌症。 ->点击阅读原文，解锁完整双语新闻 行业政策 No.1 / 国务院发布关于健全基本医疗保险参保长效机制的指导意见 2024年8月1日，国务院办公厅发布《关于健全基本医疗保险参保长效机制的指导意见》，以应对人口老龄化、就业形式多样化时代的参保需求。 进一步放开放宽在常住地、就业地参加基本医保的户籍限制。推进居民医保缴费与经济社会发展水平和居民人均可支配收入挂钩，保持财政补助和个人缴费合理的比例结构。 自2025年起，对断保人员再参保的，可降低大病保险最高支付限额；对连续参加居民医保满4年的参保人员，之后每连续参保1年，可适当提高大病保险最高支付限额。对当年基金零报销的居民医保参保人员，次年可提高大病保险最高支付限额。连续参保激励和零报销激励，原则上每次提高限额均不低于1000元，累计提高总额不超过所在统筹地区大病保险原封顶线的20%。 ->点击阅读原文，解锁完整双语新闻 No.2 / 国家药监局批复同意在京沪开展优化创新药临床审批 2024年8月2日，国家药监局批复，同意在北京、上海开展优化创新药临床试验审评审批试点。 7月31日，药监局发文决定开展优化创新药临床试验审评审批改革试点，实现30个工作日内完成创新药临床试验申请审评审批，缩短药物临床试验启动用时。 试点项目范围为1类创新药（细胞和基因治疗产品、疫苗产品等除外）临床试验申请。申请人不受区域限制，需在境内外至少获批过3个创新药临床试验申请，有丰富的临床试验实施及药物警戒管理经验，能在临床试验申请提交前对临床试验项目进行全面的风险评估并制定有效的风险管理计划。 ->点击阅读原文，解锁完整双语新闻 全球医疗情报领导者 解锁隐藏在数据中的商业潜力  关于 G B I ” 自从2002年成立以来，GBI始终以技术为驱动，为药企、器械及行业相关服务商提供贯穿生命周期的全球药品市场竞争数据、全球行业资讯、HCPs洞察、全国医疗器械数据等商业信息与洞察，助力企业在进行战略布局和决策时，脱颖而出。历经20余年的深耕细作GBI已成为95%以上跨国药企、国内头部药企、咨询与投资机构等医疗圈灯塔用户值得信赖的长期合作伙伴。 联系我们 投稿 | 发稿 | 媒体合作 ▶ zhangxinyue13@baidu.com 数据库 | 咨询服务 | 资讯追踪 ▶ 点击左下“阅读原文”完成表单填写 点击阅读原文，解锁完整双语新闻