作者: Zabeu, Giovanna Speranza ; Wang, Linda ; Costa, Mylena Proença ; Jacomine, Juliana Carvalho ; de Souza, Isabella Dorigheto ; Giacomini, Marina Ciccone

OBJECTIVEThe emergence of new resin composites (RCs) incorporating bioactive ingredients and/or used as bulk-fill materials aims to enhance restorative potential beyond just the mechanical properties. However, this innovation may affect their performance under clinically simulated conditions, such as erosive challenges (EC). This study evaluated the impact of different technologies on the hygroscopic properties of RCs.MATERIALS AND METHODSThe evaluated materials were: Gold Label - GL (resin-modified glass-ionomer cement - control); Filtek Z350 - FZ (no bioactive control); Filtek One Bulk - FO (bulk-fill); Beautifil II - BII (bioactive/S-PRG); Beautifil Bulk - BB (bioactive/S-PRG + bulk-fill). Disk-shaped specimens (10 mm x1 mm) were prepared and evaluated by: 1) water sorption - WS and solubility - WSB (n = 10); 2) wettability - W (n = 6); 3) surface microhardness - SM (n = 6); 4) qualitative surface analysis by SEM (n = 3). Except for WS and WSB, tests were performed before and after EC. Data were analyzed by two-factor ANOVA and Tukey tests (p < 0.05).RESULTSPositive WS and negative WSB were observed for all materials. In terms of W, GL>BII>FZ>BB>FO. GL and BB exhibited similar/lower SM. EC hampered SM for all materials.CONCLUSIONSIt may be concluded that the composition and proportion of monomers have a greater influence on the hygroscopic profile of resin composites than the incorporation of bioactive components.CLINICAL SIGNIFICANCEWhile renewed technologies have introduced components to enhance the performance and practicality of resin composites, actual clinical longevity depends on challenges such as erosive conditions. Bioactive ingredients seem to be beneficial without impairing the hygroscopic profile, whereas the monomers can interfere.

2025-01-01·Joint Diseases and Related Surgery

The effects of gabapentin and pregabalin on fracture healing: A histological, radiological, and biomechanical analysis

Article

作者: Reşit Buğra Hüsemoğlu, Reşit Buğra Hüsemoğlu Reşit Buğra Hüsemoğlu ; Açan, Ahmet Emrah ; Karakılıç, Aslı ; Aydın, Mert Emre ; Turan, Gülay ; Özcan, Emrah ; Bulmuş, Özgür

OBJECTIVESThis study evaluated the impact of different doses of gabapentin and pregabalin on fracture healing in a rat femoral shaft model, with histological, radiological, and biomechanical assessments.MATERIALS AND METHODSSeventy male Wistar albino rats were divided into five groups: control, low-dose gabapentin (GBP-L, 300 mg/day), high-dose gabapentin (GBP-H, 3600 mg/day), low-dose pregabalin (PRG-L, 150 mg/day), and high-dose pregabalin (PRG-H, 600 mg/day), based on human equivalent doses. Bilateral femoral fractures were induced; the right femurs were prepared for radiological examination using microtomography, followed by histological analysis, whereas the left femurs were allocated for biomechanical testing. Drug administration began three weeks preoperatively and continued until sacrifice at either two or four weeks. Histological assessments included inflammation and transformation scoring and microtomography-measured callus volume. Biomechanical testing assessed maximum force and stiffness.RESULTSAt the fourth week, inflammation levels were significantly higher in the GBP-H, PRG-L, and PRG-H groups compared to control (p<0.01, p<0.05, and p<0.01), while transformation scores were significantly lower in these groups (p<0.01, p<0.05, and p<0.001). Low-dose pregabalin showed a borderline transformation difference (p=0.051). Microtomography analysis showed that the GBP-H group had significantly reduced callus volume versus control by the second week (p<0.01), persisting at a lower significance by week four (p<0.05). By the fourth week, PRG-H also had reduced callus volume (p<0.05). Maximum force values by the fourth week were significantly lower in the GBP-L, GBP-H, and PRG-H groups compared to control (p<0.05 for GBP-L; p<0.01 for GBP-H and PRG-H).CONCLUSIONThese findings suggest that these drugs, particularly with their high-dose applications, may lead to prolonged inflammation and hinder fracture healing by reducing callus volume and biomechanical integrity, potentially disrupting the transition from the inflammatory to reparative phases of healing.

2025-01-01·Dental Materials Journal

Evaluation of mechanical properties and ion-releasing of 3D printing resins containing S-PRG filler: A preliminary study

Article

作者: HIRAISHI, Noriko ; TSUCHIDA, Yumi ; UO, Motohiro ; SHIMADA, Yasushi ; IKEDA, Masaomi ; NIKAIDO, Toru ; USHIJIMA, Kei ; TSUJI, Yukiko

This study aimed to evaluate ionic release, flexural strength and water absorption of UDMA resins containing 0-30 wt% surface pre-reacted glass-ionomer (S-PRG) filler fabricated by a DLP 3D printer. Release of Al, B, Na, Sr and F ions were measured by inductively coupled plasma (ICP) and an ion meter. Flexural strength test and water absorption measurements were performed according to the International Organization for Standardization (ISO) 4049 standard and ISO 1567 standard, respectively. Sr ions were released the most, followed by F, B, Na and Al ions. The highest flexural strength was recorded with the S-PRG filler amount 0 wt%, followed by the S-PRG filler amounts 30, 20 and 10 wt%. Water absorption after one week was below the 32 µg/mm³ mark specified by ISO 1567. The release of ions was confirmed using UDMA-based photopolymerized resin containing S-PRG filler. Furthermore, the results suggest that this resin could be used for provisional restoration.

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适应症	最高研发状态	国家/地区	公司	日期
Bloom综合征	药物发现	韩国	PRG Science & Technology Co., Ltd.	2022-08-02
科凯恩氏综合症	药物发现	韩国	PRG Science & Technology Co., Ltd.	2022-08-02