While some investigators found oral metronidazole to be effective in reducing pain after hemorrhoidectomy, other researchers did not find a significant analgesic effect of systemic metronidazole. On the other hand, topical application of metronidazole had more consistent favorable results as Ala et al documented a remarkable analgesic effect of topical metronidazole 10% after excisional hemorrhoidectomy which was in line with Nicholson and Armestrong who also concluded similar results.
No previous study compared the analgesic effect of topical and oral metronidazole after anorectal surgery. Therefore, the present trial was conducted to compare the impact of oral versus systemic metronidazole on pain and recovery after surgery for benign anorectal conditions.

开始日期2020-01-24

申办/合作机构

Mansoura University

NCT04462588

/ CompletedN/AIIT

Are the Changes in Immature Granulocyte Count and Percentage Significant in the Decision to Continue Medical Treatment of Uncomplicated Acute Appendicitis Cases

After appendectomy was first described by Mcburney in 1889, it has been the most practiced emergency surgery in the world with the lifetime incidence of acute appendicitis being 5%-25%. Most cases are uncomplicated cases without any complications and perforation (20%-30%). Although appendectomy is still a curative therapy, medical treatment has come to the fore in uncomplicated cases after improvements in imaging methods for diagnosing acute appendicitis and especially the developments in antibiotherapy.
Medical treatment for acute appendicitis is, in fact, not a new condition. Practicing the option of elective surgery following intravenous antibiotherapy for plastron appendicitis that is among the complicated acute appendicitis has lead to further consideration of medical treatment. A number of studies conducted for this purpose suggest that conservative treatment in uncomplicated acute appendicitis may be a first-line treatment. Medical treatment of the uncomplicated acute appendicitis prevents negative appendectomies, which indicates that surgical removal of non-inflamed appendix ranging from 6% to 20%. In addition to preventing unnecessary organ loss, it ensures eliminating postoperative complications such as intestinal obstruction and wound site complications due to surgery.
Immature granulocytes (IG) are monitored in peripheral blood as immature polymorphonuclear cells because of the activation of bone marrow. Although their counts can be determined through direct inspection, they can be provided with automated systems within complete blood count parameters as well as technological developments. The increase in their number specifically suggests the activation of the bone marrow and can provide information about the infectious process before leukocytosis is observed.
This study aimed to determine the importance of IG count and percentage to evaluate the role of medical treatment and control its success in cases of uncomplicated acute appendicitis.

开始日期2019-06-01

申办/合作机构

Kahramanmaras Sütçü Imam Üniversitesi

CTR20170435

/ Completed临床3期

MK-7625A联合甲硝唑与美罗培南相比治疗复杂性腹腔感染的III期、多中心、双盲、随机、活性药物对照的临床研究

主要目的：在临床可评价人群中，根据治愈评价访视时的临床疗效在复杂性腹腔感染受试者中评估ceftolozane/他唑巴坦+甲硝唑与美罗培南相比的有效性。次要目的：根据临床疗效/微生物学疗效，在复杂性腹腔感染受试者中评估ceftolozane/他唑巴坦+甲硝唑与美罗培南相比的有效性等。

开始日期2019-03-20

申办/合作机构

默沙东研发（中国）有限公司

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100 项与盐酸甲硝唑相关的临床结果

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100 项与盐酸甲硝唑相关的转化医学

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100 项与盐酸甲硝唑相关的专利（医药）

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16,451

项与盐酸甲硝唑相关的文献（医药）

2025-09-01·SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

A multifunctional Tb-MOF constructed with triphenylamine-based hexacarboxylate ligands for highly luminescent sensing toward antibiotics and salicylaldehydes

Article

作者: Mao, Zhihan ; Yang, Fenglei ; Wang, Haiying ; Shi, Han ; Liu, Yuchen ; Yu, Xuan ; Liu, Huiyan

Antibiotics and salicylaldehydes are major organic pollutants in the environment, and their efficient selection and sensitive detection are of great significance but also challenging. A multifunctional terbium-organic framework (Tb-MOF) with multiple π-conjugated rings and basic sites decorated nanoporous channels was constructed with triphenylamine-based hexacarboxylate ligands. Structure analysis of Tb-MOF revealed that the six carboxyl groups on the skeleton of ligand exhibit considerable degree of distortion and can be regarded as three triangular nodes, which further combined the binuclear [Tb₂(COO)₆(H₂O)₄] nodes to form a new (3,3,3,6)-connected 3D net. Importantly, Tb-MOF provided the first example of luminescent MOFs constructed from triphenylamine-based hexacarboxylate ligands with multi-responsive behavior toward antibiotics and salicylaldehydes. Tb-MOF demonstrated excellent performance on the selection and recognition of two antibiotics, metronidazole (MDZ) and dimetridazole (DTZ), with the detection limit (LOD) of 0.60 and 0.95 μM, respectively. More importantly, Tb-MOF can achieve highly sensitive detection of three aldehydes, salicylaldehyde (SA), 5-methylsalicylaldehyde (5-MeSA) and 5-chlorsalicylaldehyde (5-ClSA), with LODs up to 0.58, 0.59 and 0.48 μM, respectively. Regenerated experiments indicated that Tb-MOF can be employed for the efficient detection of MDZ and SA at least five times. Thus, Tb-MOF can be potentially explored as a promising sensor to simultaneously identify antibiotics and salicylaldehydes in chemical detection and biologic environments with ultra-sensitivity, low LODs and extraordinary recycling capacity.

2025-08-01·WATER RESEARCH

Silico-oxygen bonding integrated with nano-size pore enrichment enables sustainable low-oxidant-consumption Fenton-like chemistry

Article

作者: Gao, Baoyu ; Chen, Dongdong ; Chang, Jiale ; Peng, Xiaoming ; Tian, Qingbai ; Shang, Yanan ; You, Siyuan ; Gao, Yue ; Wei, Bo ; Zhang, Xin ; Xu, Xing ; Li, Qian ; Hu, Zhen

Key bottlenecks of the persulfate-based advanced oxidation processes (AOPs) are the high dosage of persulfate and the secondary pollution of sulfate ion. In this work, a sustainable strategy involving the transformation of diatomite into a water purification catalyst consisting of nano-size pore enrichment and silico-oxygen bonding (Si/C@BD) was proposed. Results indicated that the pollutants with electron-donating groups can be quickly degraded by the Si/C@BD via amplified electron transfer process (ETP) under very low peroxymonosulfate (PMS) usage. Such "low-oxidant-consumption" Fenton-like chemistry can be also applied to other catalytic systems derived from a series of silicon-based materials. In addition, a pilot-scale device (54 L) based on ETP pathway was constructed, which provided a universal strategy to prevent direct contact of treated wastewater with oxidation additives, thereby solving the bottleneck of secondary pollution caused by sulfate dissolution associated with PMS oxidation systems. In addition, the Si/C@BD/PMS system exhibited the superior environmental significance and feasibility based on the quantitative analysis via the life cycle assessment (LCA). This work will be a significant contribution to the persulfate-based Fenton-like chemistry, emphasizing the low-persulfate-consumption and free-secondary-pollution characteristics with significant application value.

2025-07-01·SEPARATION AND PURIFICATION TECHNOLOGY

Molybdate-loaded magnetic biochar activates persulfate for efficient degradation of sulfamethazine

作者: Fang, Zhanqiang ; Peng, Yifu ; Xu, Linan

Molybdate-doped magnetic biochar (MoMBC) was synthesized using sawdust as the raw material through impregnation and pyrolysis.MoMBC was utilized to activate persulfate (PS) for the degradation of sulfamethazine (SMT).The results demonstrated that at a MoMBC dosage of 0.1 g/L and PS concentration of 2 mM, the MoMBC/PS system exhibited a stabilization of SMT degradation efficiency at a level exceeding 98.1% within 120 min.This was accompanied by a reaction rate constant was 31 times greater than observed in the MBC/PS system.Characterization anal. of MoMBC revealed that molybdate loading facilitated the redox cycling of Fe³⁺/Fe²⁺ and Mo⁶⁺/Mo⁴⁺, thereby enhancing the activation efficiency of PS and accelerating SMT degradationThrough free radical quenching experiments and ESR anal., it was found that the contribution rates of superoxide radicals and hydroxyl radicals were 44.47% and 33.09%, resp., which were the main free radicals promoting the degradation of SMT.Under the coexistence of natural organic matter and anions, the influence of MoMBC/PS system is insignificant.Its powerful broad-spectrum features make it appropriate for the degradation of diverse antibiotics, with a mineralization rate of 59.9%.The degradation of SMT undergoes processes such as oxidation, hydroxylation, and removal of SO₂.This study provides new tech. support for the practical implementation of magnetic biochar in the remediation of water pollution.

100 项与盐酸甲硝唑相关的药物交易

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