KF-17625(KF-17625) - 药物靶点：Phosphoric diester hydrolases_专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点

Phosphoric diester hydrolases

作用方式

抑制剂

作用机制

磷酸二酯水解酶抑制剂

治疗领域

免疫系统疾病呼吸系统疾病

在研适应症-

非在研适应症

哮喘

原研机构

Kyowa Kirin Co., Ltd.

在研机构-

非在研机构

Kyowa Kirin Co., Ltd.

最高研发阶段终止临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C15H10N4O

InChIKeyNDDBRRFHXNPOLY-UHFFFAOYSA-N

CAS号139339-02-9

关联

100 项与 KF-17625 相关的临床结果

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100 项与 KF-17625 相关的转化医学

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100 项与 KF-17625 相关的专利（医药）

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6

项与 KF-17625 相关的文献（医药）

2000-10-01·Journal of Medicinal Chemistry1区 · 医学

Hunting the Emesis and Efficacy Targets of PDE4 Inhibitors: Identification of the Photoaffinity Probe 8-(3-Azidophenyl)-6- [(4-iodo-1H-1-imidazolyl)methyl]quinoline (APIIMQ)

1区 · 医学

Article

作者: Macdonald, Dwight ; Rasori, Roberta ; Laliberté,, France ; Huang, Zheng ; Liu, Susana ; Robichaud, Annette ; Masson, Paul ; Perrier, Hélène

The authors introduce a new approach to improving the therapeutic window of PDE4 (type 4 cAMP-specific phosphodiesterase) inhibitors, which is aimed at the identification of the specific targets for emesis and efficacy.To this end, they prepared an emetic, efficacious, and competitive PDE4 inhibitor (APIIMQ) (I) capable of covalently tagging its biol. targets upon photoactivation.This provides the possibility of identifying the emesis and efficacy targets of PDE4 inhibitors.To the authors knowledge, this is the first reported example of the preparation of a highly emetic and efficacious PDE4 photoaffinity probe.

1997-01-01·Quantitative Structure-Activity Relationships

A Pharmacophore Model for PDE IV Inhibitors

作者: Norbert Höfgen ; Emmanuel E. Polymeropoulos

AbstractBased on conformational analysis and GRID‐contour calculations we developed a common primary pharmacophore for rolipram analog, nitraquazone and xanthine derivative PDE IV inhibitors. In spite of the structural differences exhibited by the three substance classes we could provide evidence that they share common hydrogen bonding and lipophilic enzyme binding sites.

1994-12-01·Synthetic Communications

A Facile Synthesis of 5-Phenylimidazo- [4,5-c]-[1,8]naphthyridin-4(5H)-one

作者: Nobuyuki Kato ; Yukihiro Kuge ; Toru Sugaya ; Shinji Tomioka

1-Phenyl-3-nitroso-4-amino-1,8-naphthyridin-2(1H)-one was prepared on a large scale and was converted to 5-phenylimidazo[4,5-c][1,8]naphthyridin-4(5H)-one (KF17625), which exhibits potent antiasthmatic activity.

100 项与 KF-17625 相关的药物交易

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