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更新于：2025-05-07

YM-11124

更新于：2025-05-07

概要

概要

基本信息

药物类型

小分子化药

别名

靶点-

作用方式-

作用机制

免疫抑制剂

治疗领域

免疫系统疾病

在研适应症

过敏

非在研适应症-

原研机构

Yamanouchi Pharmaceutical Co., Ltd.

在研机构

Yamanouchi Pharmaceutical Co., Ltd.

非在研机构-

权益机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C15H10N2OS

InChIKeyDPGKZDHSXINFBS-UHFFFAOYSA-N

CAS号79889-39-7

关联

100 项与 YM-11124 相关的临床结果

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100 项与 YM-11124 相关的转化医学

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100 项与 YM-11124 相关的专利（医药）

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项与 YM-11124 相关的文献（医药）

1989-01-01·Pharmacology4区 · 医学

Pharmacological Properties of YM-11124, a Selective Immunosuppressive Agent for Cell-Mediated Immunity

4区 · 医学

Article

作者: Yamada, Toshimitsu ; Mase, Toshiyasu ; Murase, Kiyoshi ; Tomioka, Kenichi

Effect of YM-11124 on cell-mediated immune responses, type I to type III allergic reactions and inflammatory reaction was determined in mice, rats and guinea pigs. YM-11124 inhibited picryl chloride- and methylated bovine serum albumin-induced delayed-type hypersensitivity reactions by the treatment during both the sensitization and the elicitation phases in mice. Bilateral adrenalectomy did not prevent the suppression of DTH response by YM-11124. YM-11124 significantly prolonged the survival time of allogenic skin grafts in mice. Furthermore, YM-11124 inhibited the passive Arthus reaction in guinea pigs and the reversed passive Arthus reaction in rats. However, YM-11124 did not affect the passive cutaneous anaphylaxis reaction in rats, Forssman shock in guinea pigs and paw edema in rats. These results indicate that YM-11124 suppresses not only cell-mediated immune responses (type IV allergic reactions) but also type III allergic reactions without influence on types I and II allergic reactions as well as acute inflammation.

1988-07-01·European Journal of Medicinal Chemistry

Imidazo[2,1-b]benzothiazoles 3: syntheses and immunosuppressive activities of 2-(m-acyloxyphenyl)imidazo[2,1-b]benzothiazoles

作者: Toshiyasu Mase ; Kenichi Tomioka ; Hideki Arima ; Kiyoshi Murase ; Toshimitsu Yamada

A series of acyl derivatives e.g., I [R = Me, Et, CO₂H (CH₂)_nCO₂H, CH:CHCO₂R¹, CH₂NH₂, CH₂NMe₂, (CH₂)₂NH₂; n = 1-3; R¹ = H, Et] of 2-(m-hydroxyphenyl)imidazo[2,1-b]benzothiazole (II), a selective immunosuppressive agent for delayed type hypersensitivity (DTH), was prepared and tested for its suppressive activity of DTH in mice after oral administration.Six compounds were more potent immunosuppressive agents than II but they showed no effect on humoral immunity as in the case of II.

1986-03-01·Journal of Medicinal Chemistry1区 · 医学

Imidazo[2,1-b]benzothiazoles. 2. New immunosuppressive agents

1区 · 医学

Article

作者: Murase, Kiyoshi ; Tomioka, Kenichi ; Yamada, Toshimitsu ; Arima, Hideki ; Mase, Toshiyasu

A series of 2-phenylimidazo[2,1-b]benzothiazole derivatives was prepared and tested for immunological activities. Some of the compounds showed significant suppressive activity of delayed type hypersensitivity (DTH) without inhibition of humoral immunity in mice by oral administration. The most active compound was 2-(m-hydroxyphenyl)imidazo[2,1-b]benzothiazole (20).

100 项与 YM-11124 相关的药物交易

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