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更新于：2025-05-07

Cinnamic alcohol

更新于：2025-05-07

概要

概要

基本信息

药物类型

小分子化药

别名

靶点-

作用方式-

作用机制-

治疗领域

神经系统疾病内分泌与代谢疾病

在研适应症

癫痫发作肥胖

非在研适应症-

原研机构-

在研机构

The Korea Food Research Institute

Universidade Federal da Paraíba

非在研机构-

权益机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C9H10O

InChIKeyOOCCDEMITAIZTP-UHFFFAOYSA-N

CAS号104-54-1

关联

100 项与 Cinnamic alcohol 相关的临床结果

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100 项与 Cinnamic alcohol 相关的转化医学

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100 项与 Cinnamic alcohol 相关的专利（医药）

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7,497

项与 Cinnamic alcohol 相关的文献（医药）

2025-08-01·Journal of Pharmaceutical and Biomedical Analysis

Exploration of material basis: Chemical composition profile and metabolic profile in Xiao Jianzhong Granules

Article

作者: Sun, Lixin ; Wang, Hongjin ; Li, Caihong ; Zhou, Xuanxuan ; Zheng, Ling ; Wang, Jiaxue

Xiao Jianzhong Granules (XJZG), a well-known traditional prescription with protective effects on the gastric mucosa, as documented in the Treatise on Typhoid and Miscellaneous Diseases. Clinical studies have proven that XJZG exhibits significant anti-colitis properties and effectively alleviates duodenal ulcers. However, despite its clinical popularity, comprehensive studies on its chemical composition and in vivo metabolism remain limited. In the present study, gas chromatography coupled with mass spectrometry (GC-MS) and ultra-high-performance liquid chromatography coupled with Q-Exactive Orbitrap mass spectrometry (UHPLC Q-Exactive Orbitrap MS) were used to analyze the chemical composition of XJZG, while it is in vivo metabolic profile was further assessed with UHPLC Q-Exactive Orbitrap MS. Additionally, ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC-MS/MS) was utilized to quantify its primary components. As a result, a total of 51 volatiles were characterized by GC-MS, and 139 compounds were characterized by UHPLC Q-Exactive Orbitrap MS in vitro. In addition, 51 prototype components and 133 metabolites were characterized in vivo. Notably, 5 new compounds were discovered in this process. The main metabolic reactions included oxidation, reduction, hydrolysis, glucuronidation, and sulfate esterification. In quantitative analysis, 17 components were determined and successfully applied for detection by UPLC-MS/MS in multiple reaction monitoring mode. The quantitative methods were validated and met the requirements. Through multivariate statistical analysis, 6 components were selected as potential quality markers for XJZG based on PCA and OPLS-DA. Additionally, our study provides supplementary chemical evidence to further elucidate the material basis of XJZG.

2025-08-01·Applied Catalysis B: Environment and Energy

High-performance CuNi-alloy catalysts for efficient solvent-free hydrogenation furfural to furfuryl alcohol

作者: Zhao, Shuailong ; Jia, Wenlong ; Zhang, Rui ; Sun, Yong ; Liu, Huai ; Zhang, Junhua ; Rao, Zilong ; Peng, Lincai ; Zhang, Yu

Achieving high substrate concentration and low hydrogen pressure in alc. production has long posed a challenge in catalysis, especially solvent-free hydrogenation reactions.Herein, we report a NiCu-alloy catalyst with both high activity and excellent stability for the solvent-free hydrogenation of furfural (FF) to furfuryl alc. (FA) at 110°C and 3 bar H₂.Cu₁Ni₁O_x/C gave a turnover frequency as high as 13458.8 h^-1, significantly outperforming reported reaction systems (<6273 h^-1).Upon scaling up the reaction system to 100 mL, the yield of FA remained above 99%.The study of adsorption sites unveiled the critical role of Ni⁰(111) in the homolytic cleavage of H₂ and FF adsorption via the mode of η²(O)-aldehyde.The upward shift of the d-band center in the copper-doped catalyst improved the adsorption configuration of FF and reduced the reaction barrier more efficiently.Moreover, Cu₁Ni₁O_x/C catalyst can be employed for the solvent-free hydrogenation of aldehydes and ketones derivatives with versatile structures.Overall, this research enhances the comprehension of electronic interactions at the interface of CuNi-alloy catalysts and offers a promising approach for designing catalysts for solvent-free hydrogenation of aldehydes and ketones.

2025-07-01·Metabolic Engineering

Stress-driven dynamic regulation of multiple genes to reduce accumulation of toxic aldehydes

Article

作者: Xu, Chao ; Jiang, Xinglin ; Jin, Miaomiao ; Jin, Ping ; Xian, Mo ; Liu, Wei ; Yuan, Shan

Aldehydes are ubiquitous metabolites in living cells. As reactive electrophiles, they have the capacity to form adducts with cellular protein thiols and amines, leading to potential toxicity. Dynamic regulation has proven to be an effective strategy for addressing the accumulation of toxic metabolites. However, there are limited reports on applying dynamic control specifically to mitigate aldehyde accumulation. In this study, the cinnamaldehyde accumulation in the biosynthesis of cinnamylamine was used as a model to evaluate a two-way dynamic regulation strategy. First, we utilized whole-genome transcript arrays to identify the cinnamaldehyde-responsive promoters: the upregulated promoter P₄ and the downregulated promoter P_d. They were then employed as biosensors to dynamically regulate the synthesis and consumption of cinnamaldehyde, mitigating its toxic effects on the host. This strategy successfully reduced cinnamaldehyde accumulation by 50 % and increased the production of cinnamylamine by 2.9 times. This study demonstrated a cinnamaldehyde-induced autoregulatory system that facilitated the conversion of cinnamic acid into cinnamylamine without the need for costly external inducers, presenting a promising and economically viable approach. The strategy also serves as a reference for alleviating the inhibitory effects of other toxic aldehydes on microorganisms. Additionally, the biosensors (P_d and P₄) can respond to a range of aldehyde compounds, offering a rapid and sensitive method for detecting toxic aldehydes in both environmental samples and microorganisms, thus provide a valuable tool for screening strains enhanced aldehyde yield.

100 项与 Cinnamic alcohol 相关的药物交易

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