NT-100(NT-100) - 在研适应症：女性不孕症_专利_临床

概要

基本信息

药物类型

合成多肽

别名

靶点-

作用机制

免疫调节剂

治疗领域

泌尿生殖系统疾病

在研适应症

女性不孕症

非在研适应症

流产习惯性流产1型阵发性家族性心室颤动

原研机构

Nora Therapeutics, Inc.

在研机构

Nora Therapeutics, Inc.

非在研机构-

最高研发阶段临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

4

项与 NT-100 相关的临床试验

NCT02156063 / Unknown status临床2期

A Randomised, Double Blind, Multi-center, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of NT100 in Pregnant Women With a History of Unexplained Recurrent Pregnancy Loss (RPL)

This is a randomised, double blind, multi-center, placebo-controlled study of subcutaneous NT100 in pregnant women with a history of unexplained recurrent pregnancy loss. Approximately 150 participants will be randomised to receive subcutaneous NT100 or placebo.

开始日期2014-06-01

申办/合作机构

Nora Therapeutics, Inc.

EUCTR2014-000084-40-GB / Not yet recruiting临床2期

A randomized, double blind, multi-center, placebo-controlled study to evaluate the efficacy, safety, and tolerability of NT100 in pregnant women with a history of unexplained recurrent pregnancy loss (RPL).

开始日期2014-04-07

申办/合作机构

Nora Therapeutics, Inc.

NCT01978561 / Completed临床2期

Pregnancy, Delivery, And Neonatal Outcomes In Subjects With Ongoing Pregnancies Established During Study NT-03 (Thrive-IVF Follow-Up)

The purpose of this study is to evaluate pregnancy, delivery, and neonatal outcomes in subjects who maintain ongoing clinical pregnancies through Week 10 of gestation in NT-03.

开始日期2013-10-01

申办/合作机构

Nora Therapeutics, Inc.

100 项与 NT-100 相关的临床结果

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100 项与 NT-100 相关的转化医学

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100 项与 NT-100 相关的专利（医药）

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3

项与 NT-100 相关的文献（医药）

2024-03-18·Ying yong sheng tai xue bao = The journal of applied ecology

长期免耕和秸秆覆盖量对黑土碳氮含量及碳氮循环相关酶活性的影响.

Article

作者: Xu, Xin ; Xie, Hong-Tu ; Yang, Ya-Li ; Bao, Xue-Lian ; Yu, Yang ; Zheng, Tian-Tian ; Lyu, Fu-Ze ; Zhang, Chang-Ren

为探究免耕条件下不同秸秆覆盖量对黑土碳氮含量及酶活性的影响,寻找既能满足土壤碳氮积累需求,又能使经济效益最大化的秸秆覆盖量,本研究依托始建于2007年的东北黑土区保护性耕作长期定位试验平台,于2020年5月春播前对传统耕作(对照,CT)、免耕+无秸秆覆盖(NT₀)、免耕+33%秸秆覆盖(NT₃₃)、免耕+67%秸秆覆盖(NT₆₇)和免耕+100%秸秆覆盖(NT₁₀₀)处理下土壤碳氮含量、土壤酶活性及经济效益进行分析。结果表明:1)与CT相比,NT₀的土壤有机碳(SOC)和总氮(TN)含量没有显著变化,但提高了土壤有机质抗分解性,降低了可溶性有机氮(DON)和铵态氮等可利用养分含量。与NT₀相比,免耕秸秆覆盖显著增加了0～10 cm土层SOC含量,且随着覆盖量的增加而增加,此外NT₆₇和NT₁₀₀还显著提高了SOC储量,有机质积累效果好。不同秸秆覆盖量对0～10 cm土层土壤氮的影响不同,NT₃₃显著提高了DON含量及其占TN的比例;NT₆₇显著提高了DON含量;NT₁₀₀显著提高了TN含量。2)与CT相比,NT₀显著降低了0～10 cm土层过氧化物酶(POD)活性。与NT₀相比,NT₃₃显著提高了0～10 cm土层β-葡萄糖苷酶(βG)、纤维二糖酶(CB)、β-N-乙酰氨基葡萄糖苷酶(NAG)、多酚氧化酶(PPO)和POD活性,NT₆₇仅提高了CB、NAG和POD活性,但二者均缓解了微生物养分氮限制;NT₁₀₀则显著提高了10～20 cm土层PPO活性。3)NT₃₃的秸秆碳转化效率显著高于NT₁₀₀,其经济收益也最高。综上,免耕33%秸秆覆盖处理既能促进养分循环,提高秸秆利用效率,提升黑土质量,又能最大限度保证农民收入,是本试验条件下的最佳组合。.

2023-03-01·Biomedical Materials

TiO₂ nanotubes induce early mitochondrial fission in BMMSCs and promote osseointegration

Article

作者: Zhang, Zhouyang ; Xin, He ; Liu, Fuwei ; Hou, Yan ; Kong, Liang ; Ning, Xiaona ; Lv, Qian-Xin ; Chen, Yicheng ; Wang, Le ; Jia, Xuelian

AbstractNanotopography can promote osseointegration, but how bone marrow mesenchymal stem cells (BMMSCs) respond to this physical stimulus is unclear. Here, we found that early exposure of BMMSCs to nanotopography (6 h) caused mitochondrial fission rather than fusion, which was necessary for osseointegration. We analyzed the changes in mitochondrial morphology and function of BMMSCs located on the surfaces of NT100 (100 nm nanotubes) and ST (smooth) by super-resolution microscopy and other techniques. Then, we found that both ST and NT100 caused a significant increase in mitochondrial fission early on, but NT100 caused mitochondrial fission much earlier than those on ST. In addition, the mitochondrial functional statuses were good at the 6 h time point, this is at odds with the conventional wisdom that fusion is good. This fission phenomenon adequately protected mitochondrial membrane potential (MMP) and respiration and reduced reactive oxygen species. Interestingly, the MMP and oxygen consumption rate of BMMSCs were reduced when mitochondrial fission was inhibited by Mdivi-1(Inhibition of dynamin-related protein 1 fission) in the early stage. In addition, the effect on osseointegration was significantly worse, and this effect did not improve with time. Taken together, the findings indicate that early mitochondrial fission plays an important role in nanotopography-mediated promotion of osseointegration, which is of great significance to the surface structure design of biomaterials.

2020-01-01·Birth Defects Research4区 · 医学

Defect evaluation by infant photographs in a multicenter pharmaceutical clinical trial

4区 · 医学

Article

作者: Kwon, Paul ; Joing, Mark ; Scheuerle, Angela E.

AbstractObjectThe NT‐04 clinical trial of investigational medication NT100 had a limited, though geographically diverse, study population. To enhance potential birth defect identification, photographic dysmorphology exam of infants was performed along with review of prenatal and postnatal medical records.MethodsStandardized photographic views were developed: full body (prone and supine), face, both profiles, dorsal and ventral hands and feet, genitalia, and birthmarks/skin lesions. Professional photographers were identified and trained. Photos were taken in the first month of life at the subject's home and uploaded to a secure electronic online photo viewer. The evaluating geneticist accessed the photos electronically and submitted an evaluation.ResultsForty subjects had 39 evaluable outcomes (55 babies). Twelve photographers were recruited, 10 of whom worked with multiple subjects. Photographic dysmorphology evaluation was done on 38 pregnancy outcomes. Only one baby had missing photos due to an apparent protocol error. Four babies were photographed with diaper on.ConclusionsThe standardized photographs worked well. Advantages include: a single clinician evaluating all infants, the photographs could be reviewed repeatedly as needed, and minor malformations were more uniformly identified. Difficulties were: identifying local photographers and supplying training and training materials. There was no protocol for retaking or obtaining new photos and the study consent form did not include permission to publish the photographs. This was a successful pilot study of infant photographic assessment to detect congenital anomalies in a clinical trial.

100 项与 NT-100 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
女性不孕症	临床3期	英国	Nora Therapeutics, Inc.	-
流产	临床前	英国	Nora Therapeutics, Inc.	2014-06-01
习惯性流产	临床前	英国	Nora Therapeutics, Inc.	2014-06-01
1型阵发性家族性心室颤动	临床前	美国	Nora Therapeutics, Inc.	2013-05-01