SB-P8B2(SB-P8B2) - 药物靶点：FtsZ_专利_临床

概要

基本信息

药物类型

小分子化药

别名

SB P8B2、SBP8B2

靶点

FtsZ

作用方式

抑制剂

作用机制

FtsZ抑制剂(FtsZ蛋白抑制剂)

治疗领域

感染

在研适应症-

非在研适应症

结核

原研机构

Stony Brook University

在研机构-

非在研机构

Stony Brook University

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C22H32N4O2

InChIKeyMMGPENLTZQKVBO-UHFFFAOYSA-N

CAS号1259926-60-7

关联

100 项与 SB-P8B2 相关的临床结果

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100 项与 SB-P8B2 相关的转化医学

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100 项与 SB-P8B2 相关的专利（医药）

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9

项与 SB-P8B2 相关的文献（医药）

2022-06-21·Antimicrobial agents and chemotherapy

High-Throughput Screening Platform To Identify Inhibitors of Protein Synthesis with Potential for the Treatment of Malaria

Article

作者: Terán, Fernando Sánchez-Román ; Wyllie, Susan ; Fisher, Fabio ; Wrobel, Karolina ; Gilbert, Ian H. ; Edwards, Darren ; Baragana, Beatriz ; Milne, Rachel ; Baumann, Hella ; Tamaki, Fabio ; Wiedemar, Natalie ; Baum, Jake

Artemisinin-based combination therapies have been crucial in driving down the global burden of malaria, the world’s largest parasitic killer. However, their efficacy is now threatened by the emergence of resistance in Southeast Asia and sub-Saharan Africa.

2019-03-01·Antimicrobial agents and chemotherapy2区 · 医学

Screening the Pathogen Box for Identification of New Chemical Agents with Anti- Fasciola hepatica Activity

2区 · 医学

Article

作者: Pajuelo, Monica ; Timoteo, Olga ; Ortiz, Pedro ; Vaisberg, Abraham ; Soto, Maria Pia ; Machicado, Claudia ; Marcos, Luis A.

Fascioliasis is an infectious parasitic disease distributed globally and caused by the liver fluke Fasciola hepatica or F. gigantica . This neglected tropical disease affects both animals and humans, and it represents a latent public health problem due to the significant economic losses related to its effects on animal husbandry.

2018-09-01·Antimicrobial agents and chemotherapy2区 · 医学

Screening of Preselected Libraries Targeting Mycobacterium abscessus for Drug Discovery

2区 · 医学

Article

作者: Av-Gay, Yossef ; Chao, Joseph ; Ko, Mary ; Strauch, Angelika ; Richter, Adrian

Mycobacterium abscessus is intrinsically resistant to many antimycobacterial antibiotics, which presents serious problems in therapy. Here, we describe the development of a novel phenotype-based microscopic and computerized imaging drug screening approach.

100 项与 SB-P8B2 相关的药物交易

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