2001-02-01·Bioorganic & Medicinal Chemistry Letters4区 · 医学
Identification and characterization of a potential ischemia-selective N-methyl-d-aspartate (NMDA) receptor ion-channel blocker, CNS 5788
4区 · 医学
Article
作者: James B Fischer ; Michael E Perlman ; Robert N McBurney ; Seetharamaiyer Padmanabhan ; Lu Zhang ; Graham J Durant ; Dan Zhou ; Deke Moore
The identification and characterization of a potentially ischemia-selective and orally-active sulfoxide based NMDA ion-channel blocker showing good neuroprotective activity, (R)-(+)-N-(2-chloro-5-methylthiophenyl)-N'-(3-methylsulfinylphenyl)-N'-methylguanidine (CNS 5788), is described.