更新于：2024-06-20
Cobamamide
腺苷钴胺
更新于：2024-06-20
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C72H100CoN18O17P |
InChIKeyDWKMERNBNCCNEZ-RQKYJTTQSA-M |
CAS号13870-90-1 |
关联
2
项与 腺苷钴胺 相关的临床试验The Role of Cobamamide Supplements in Malnourished Patients
A Randomized, Phase 2, Double-Blind, Placebo-Controlled Trial to Evaluate the Safety and Efficacy of HL-009 Liposomal Gel in Adult Patients With Mild to Moderate Atopic Dermatitis
100 项与 腺苷钴胺 相关的临床结果
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100 项与 腺苷钴胺 相关的转化医学
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100 项与 腺苷钴胺 相关的专利（医药）
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388
项与 腺苷钴胺 相关的文献（医药）2023-12-06ACS applied materials & interfaces
Chaotropic Effect-Induced Self-Assembly of the Malachite Green and Boron Cluster for Toxicity Regulation and Photothermal Therapy
Article
作者: Zhang, Haibo ; Chen, Xiaofang ; Xu, Shi-Yuan ; Wang, Zi-Xin ; Ye, Yu-Yuan ; Liu, Xinyu ; Li, Wen-Zhen ; Wang, Xiao-Qiang
Malachite green (MG), a toxic antibacterial agent, is widely used in the farming industry. Effectively regulating the biotoxicity of this highly water-soluble cationic dye is challenging. Here, we present a novel strategy to reduce the biotoxicity of MG through the self-assembly of MG and the closo-dodecaborate cluster ([B12H12]2-) driven by the chaotropic effect. [B12H12]2- and MG in an aqueous solution can rapidly form an insoluble cubic-type supramolecular complex (B12-MG), and the original toxicity of MG is completely suppressed. Surprisingly, this supramolecular complex, B12-MG, has a strong UV-vis absorption peak at 600-800 nm and significant photothermal conversion efficiency under 660 nm laser irradiation. On this basis, B12-MG, the supramolecular complex, can be used as an efficient photothermal agent for antimicrobial photothermal therapy (PTT) both in vitro and in vivo. As a molecular chaperone of MG, [B12H12]2- not only can be applied as an antidote to regulate the biotoxicity of MG but also provides a novel method for the construction of photothermal agents for PTT based on the chaotropic effect.
2023-11-05Cureus
A Case of Subacute Degeneration of the Spinal Cord Due to Vitamin B12 Deficiency Triggered by Nitrous Oxide Use
作者: Cooney, Lewis ; Akhtar, Junaid ; Soh Weng Yan, Alvin ; Ali, Abuobeida ; Prasad, Yash ; Davies, Michael ; Kong, Jordon ; Maheswaran, Tina
In this case report, we discuss a young female who presented to the emergency department with a recent onset of weakness, paraesthesia, and gait disturbance suggestive of peripheral neuropathy and gait ataxia. This was attributed to the occasional use of recreational nitrous oxide (N2O) over the past 10 months. Subacute combined degeneration of the spinal cord is a condition affecting the lateral and posterior columns of the spinal cord, mainly caused by demyelination. The use of recreational N2O depletes the levels of vitamin B12 thus leading to this demyelination of the nervous system. Physical examination revealed T6 and T7 and L3 and L4 sensory deficits bilaterally with hyporeflexia in bilateral knee and ankle reflexes with reduced power in the left lower limb as well as a spastic gait. Her vitamin B12 levels were low (98 g/dL). MRI spine showed a high signal in the posterior cord/ dorsal column. The patient made good recovery post-intramuscular B12 administration and physiotherapy with planned outpatient neurology rehabilitation.
2023-10-01Molecular therapy : the journal of the American Society of Gene Therapy
Targeting leucine-rich repeat serine/threonine-protein kinase 2 sensitizes pancreatic ductal adenocarcinoma to anti-PD-L1 immunotherapy
Article
作者: Tang, Jianghui ; Zhang, Hanjia ; Guo, Chengxiang ; Zhou, Jingxing ; Lin, Jieru ; Hong, Yifan ; Yang, Hanshen ; Hong, Zhengtao ; Liang, Tingbo ; Bai, Xueli ; He, Lihong ; Sun, Kang ; Li, Muchun ; Song, Jinyuan ; Chen, Yan ; Liu, Xinyuan ; Lao, Mengyi ; Huang, Jinyan ; Xu, Jian ; Zhang, Xiaozhen ; Zhang, Sirui ; Wang, Sicheng
Pancreatic ductal adenocarcinoma (PDAC) is not sensitive to immune checkpoint blockade therapy, and negative feedback of tumor immune evasion might be partly responsible. We isolated CD8+ T cells and cultured them in vitro. Proteomics analysis was performed to compare changes in Panc02 cell lines cultured with conditioned medium, and leucine-rich repeat kinase 2 (LRRK2) was identified as a differential gene. LRRK2 expression was related to CD8+ T cell spatial distribution in PDAC clinical samples and upregulated by CD8+ T cells via interferon gamma (IFN-γ) simulation in vitro. Knockdown or pharmacological inhibition of LRRK2 activated an anti-pancreatic cancer immune response in mice, which meant that LRRK2 acted as an immunosuppressive gene. Mechanistically, LRRK2 phosphorylated PD-L1 at T210 to inhibit its ubiquitination-mediated proteasomal degradation. LRRK2 inhibition attenuated PD-1/PD-L1 blockade-mediated, T cell-induced upregulation of LRRK2/PD-L1, thus sensitizing the mice to anti-PD-L1 therapy. In addition, adenosylcobalamin, the activated form of vitamin B12, which was found to be a broad-spectrum inhibitor of LRRK2, could inhibit LRRK2 in vivo and sensitize PDAC to immunotherapy as well, which potentially endows LRRK2 inhibition with clinical translational value. Therefore, PD-L1 blockade combined with LRRK2 inhibition could be a novel therapy strategy for PDAC.
100 项与 腺苷钴胺 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 营养紊乱 | 中国 | 1995-01-01 | |
| 巨幼红细胞性贫血 | 日本 | 1967-01-19 | |
| 恶性贫血 | 日本 | 1967-01-19 | |
| 关节痛 | 日本 | 1967-01-19 | |
| 中枢神经系统疾病 | 日本 | 1967-01-19 | |
| 面瘫 | 日本 | 1967-01-19 | |
| 白细胞减少 | 日本 | 1967-01-19 | |
| 吸收不良综合征 | 日本 | 1967-01-19 | |
| 肌痛 | 日本 | 1967-01-19 | |
| 神经痛 | 日本 | 1967-01-19 | |
| 神经炎 | 日本 | 1967-01-19 | |
| 绦虫病 | 日本 | 1967-01-19 | |
| 维生素B12缺乏症 | 日本 | 1967-01-19 | |
| 贫血 | - | - | - |
| 坐骨神经痛 | - | - | - |
| 三叉神经痛 | - | - | - |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 特应性皮炎 | 临床2期 | 美国 | 2012-03-01 |
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