2011-04-12·Journal of Pharmacy and Pharmacology3区 · 医学
The structure of phenindamine base and salts in the solute state
3区 · 医学
Article
作者: Branch, S K ; Upton, C ; Hussain, R ; Casy, A F
AbstractHigh-field NMR (13C and 1H) studies of phenindamine are reported which establish structures of the free base and some of its salts in the solute condition. The base exists as a mixture of two isomers which differ in double bond position (9–9a or 4a–9a) while most salts are 9–9a isomers. The clinically employed tartrate (Thephorin) is exceptional in being a 4a–9a ene. Salts of both double bond type exist in solution as mixtures of protonated epimers of variable epimeric ratio, that of the tartrate in D2O being approximately 1:1.
2011-04-12·Journal of Pharmacy and Pharmacology3区 · 医学
The Identification and Determination of Nitrogenous Organic Bases with Ammonium Reineckate
3区 · 医学
Article
作者: Kum-Tatt, Lee
AbstractThe identification and determination of several important bases as their reineckates is described. The ultra-violet and visible spectra of reineckates were studied and used for the determination of molecular weights and solubilities and for the determination of bases. This paper also records as yet unreported constants of the characteristic mono- and di-reineckate derivatives of several clinically important compounds. A method for the regeneration of the conjugate bases from the reineckates using ion exchange resins is also given.
2011-04-12·Journal of Pharmacy and Pharmacology3区 · 医学
The Scope of Phenol-Chloroform-Acetonitrile as A Solvent System in Nonaqueous Titrimetry
3区 · 医学
Article
作者: Chatten, L G
cf. C.A. 49, 3476h, 3719g.Potentiometric and visual indicator titrations in PhOH-CHCl3-acetonitrile with O.05N HClO4 in dioxane are recorded for sulfates of amphetamine, d-amphetamine, ephedrine, morphine, codeine, butacaine, quinine, cinchonine, cinchonidine, strychnine, physostigmine, physostigmine salicylate, phenindamine tartrate, pilocarpine nitrate, codeine phosphate, morphine acetate, dihydrocodeinone bitartrate, and dioxyline phosphate.