Argidene

Patients in the highest dose group achieved an overall mean 6.1 letter improvement in Best Corrected Vision (BCVA) at Month 3, of which: 63% showed at least a 5-letter gain 38% achieved at least a 10-letter gain 13% achieved at least a 15-letter gain Oxurion intends to present a more complete data set from Part A of the KALAHARI study at an upcoming leading ophthalmology conference Leuven, BE, Boston, MA, US –October 11, 2021 – 07.00 AM CET – Oxurion NV (Euronext Brussels: OXUR), a biopharmaceutical company developing next generation standard of care ophthalmic therapies, is delighted to announce that further characterization of the BCVA data from the previously reported Part A portion of the Phase 2 (“KALAHARI”) study of THR-149 was shared at the American Society for Retinal Specialists (ASRS) Annual Scientific Meeting. THR-149 is a plasma kallikrein inhibitor, being developed for the treatment of the 40-50% of DME patients who sub-optimally respond to standard of care anti-VEGF therapy. As previously announced, results from Part A demonstrated that all dose levels of THR-149 had a favorable safety profile. All adverse events in the study eye were mild to moderate in intensity and no severe ocular adverse events were reported and no inflammation observed. The highest dose of THR-149 (0.13mg) produced the largest improvement in BCVA, the primary endpoint for registration in DME studies. The highest dose delivered a mean 6.1 letter improvement at Month 3 with no patients requiring rescue medications. Further characterization of the BCVA data was shared yesterday during ASRS by Arshad M. Khanani, M.D., M.A., Director of Clinical Research at Sierra Eye Associates, Reno, Nevada, US, “I am happy to report that in patients, who had been suboptimally treated with anti-VEGF therapy, the highest dose of THR-149 was able to achieve at least a 5-letter gain in 63% of patients, of these 38% patients achieved at least a 10-letter gain, and 13% saw at least a 15-letter gain. In addition,CST was stable and a change of 13 µm observed at Month 3.These results demonstrate the potential of THR-149 to make a real difference to this patient population,which if left untreated would be expected to see a further deterioration in their vision.” Tom Graney, CFA, Chief Executive Officer of Oxurion, comments, “These data provide proof of concept for multiple injections of THR-149, our potent plasma kallikrein inhibitor, in this important underserved DME patient population.We are very excited that in these patients, who currently do not have suitable treatment options, over60% gained at least a full line improvement in vision from baseline when treated with the highest dose of THR-149.” In Part B of this study, we hope to confirm THR-149’s ability to address the significant unmet need in this large patient population thatexperience a suboptimal response to anti-VEGFs and as a result currently lack adequate treatment options.” Based on the results from Part A of the Phase 2 study, the Company is advancing the high dose of THR-149 (0.13mg) into Part B of the study which will enroll just over one hundred patients who have previously shown a suboptimal response to anti-VEGF therapy, and where THR-149 will be evaluated against aflibercept, the current standard of care, as the active comparator. Final topline results from the KALAHARI study are expected in mid-2023. Oxurion intends to present a more complete data set from Part A of the KALAHARI study at an upcoming leading ophthalmology conference. END Oxurion NV Tom Graney Chief Executive Officer Tel: +32 16 75 13 10 tom.graney@oxurion.com Michael Dillen Chief Corporate Development Tel: +32 479 783583 michael.dillen@oxurion.com EU MEDiSTRAVA Consulting David Dible/ Sylvie Berrebi/Frazer Hall Tel: +44 20 7638 9571 oxurion@medistrava.com US Westwicke, an ICR Company Christopher Brinzey Tel: +1 617 835 9304 chris.brinzey@westwicke.com About Oxurion Oxurion (Euronext Brussels: OXUR) is a biopharmaceutical company developing next generation standard of care ophthalmic therapies, which are designed to better preserve vision in patients with retinal vascular disorders including diabetic macular edema (DME), the leading cause of vision loss in diabetic patients worldwide as well as other conditions, including wet age-related macular degeneration (AMD) and retinal vein occlusion (RVO). Oxurion is aiming to build a leading global franchise in the treatment of retinal vascular disorders based on the successful development of its two novel therapeutics: THR-687 is a highly selective pan-RGD integrin antagonist that is initially being developed as a potential first line therapy for DME patients. Positive topline results in a Phase 1 clinical study assessing THR-687 as a treatment for DME were announced in 2020. Oxurion is currently conducting a Phase 2 clinical trial (“INTEGRAL”) evaluating THR-687 in patients with DME. THR-687 also has the potential to deliver improved treatment outcomes for patients with wet AMD and RVO. THR-149 is a potent plasma kallikrein inhibitor being developed as a potential new standard of care for the 40-50% of DME patients showing suboptimal response to anti-VEGF therapy. THR-149 has shown positive topline Phase 1 results for the treatment of DME. The company is currently conducting a Phase 2 clinical trial (“KALAHARI”) evaluating multiple injections of THR-149 in DME patients previously showing a suboptimal response to anti-VEGF therapy. Following positive data from Part A of this Phase 2 study (dose selection), the Company has initiated Part B of the study. Oxurion is headquartered in Leuven, Belgium, and is listed on the Euronext Brussels exchange under the symbol OXUR. More information is available at . Important information about forward-looking statements Certain statements in this press release may be considered “forward-looking”. Such forward-looking statements are based on current expectations, and, accordingly, entail and are influenced by various risks and uncertainties. The Company therefore cannot provide any assurance that such forward-looking statements will materialize and does not assume an obligation to update or revise any forward-looking statement, whether as a result of new information, future events, or any other reason. Additional information concerning risks and uncertainties affecting the business and other factors that could cause actual results to differ materially from any forward-looking statement is contained in the Company’s Annual Report. This press release does not constitute an offer or invitation for the sale or purchase of securities or assets of Oxurion in any jurisdiction. No securities of Oxurion may be offered or sold within the United States without registration under the U.S. Securities Act of 1933, as amended, or in compliance with an exemption therefrom, and in accordance with any applicable U.S. state securities laws.

THR-687 is a potent pan-RGD integrin antagonist holding potential as next generation first line therapy for DME, wet AMD and RVO Phase 2 Clinical Study THR-687 in DME currently recruiting patients Leuven, BE, Boston, MA, US – August 17, 2021 – 08.00 AM CET -  Oxurion NV (Euronext Brussels: OXUR), a biopharmaceutical company developing next generation standard of care ophthalmic therapies, with a clinical stage portfolio in vascular retinal disorders, announces that the positive Phase 1 study of THR-687, a novel, highly potent integrin agonist for the treatment of DME has just been published in Ophthalmology Science, the journal of the American Academy of Ophthalmology. The multicenter, dose escalation study was designed to evaluate the safety and preliminary efficacy of three dose levels of THR-687 (0.4, 1.0 or 2.5mg) in subjects with center-involved DME following a single intravitreal injection. As reported from the top line data in 2020, a single injection of THR-687 was safe and well tolerated, showing a very encouraging efficacy signal as measured by a rapid gain in BCVA with three months durability and a decrease in CST up to one month following the injection. A clear dose response was seen with the greatest positive effect on BCVA and Central Subfield Thickness (CST) with the highest dose of THR-687. For this highest dose, a mean BCVA Improvement of 11 letters was noted at Day 14, with a peak improvement of 12.5 letters at Month 3. Similarly, a peak mean CST decrease of 106 µm was observed at Day 14 with the highest dose of THR-687. THR-687 will next be investigated in the INTEGRAL Phase 2 study, a randomized, multicenter trial in DME. This is the first trial in which multiple intravitreal injections of THR-687 will be administered in humans. The two-part study will assess different dose levels of multiple THR-687 injections (Part A) and then go on to evaluate the efficacy and safety of the selected dose of THR-687 versus aflibercept (the current standard of care) for the treatment of DME (Part B). The dose selection decision, following Part A, is anticipated in the first half of 2022 and top line data from Part B is expected in the second half of 2023.  Tom Graney, CFA, CEO of Oxurion comments, “I am pleased that the significance of the Phase 1 THR-687 data has been recognised by its publication in the prestigious American Academy of Ophthalmology journal. The highly promising results from just a single dose of THR-687 have warranted the planning of the Phase 2 study which just opened enrolment of patients. There remains a significant unmet medical need in DME and THR-687 has the potential to be a transformative first line therapy for the many patients suffering from this serious condition. We would like to thank the patients for their participation in the Phase 1 study as well as the world-class investigators that worked on the trial and the publication.” Beyond DME, THR-687 has the potential to be developed for additional vascular retinal disorders including for wet Age-related Macular Degeneration (wet AMD) and retinal vein occlusion (RVO). These additional indications, alongside DME, mean that THR-687, is targeting a total market opportunity estimated to be worth $12+ billion annually. Article can be accessed at: END For further information please contact: About Oxurion Oxurion (Euronext Brussels: OXUR) is a biopharmaceutical company developing next generation standard of care ophthalmic therapies, which are designed to better preserve vision in patients with retinal vascular disorders including diabetic macular edema (DME), the leading cause of vision loss in diabetic patients worldwide as well as other conditions, including wet age-related macular degeneration (AMD) and retinal vein occlusion (RVO). Oxurion is aiming to build a leading global franchise in the treatment of retinal vascular disorders based on the successful development of its two novel therapeutics: Oxurion is headquartered in Leuven, Belgium, and is listed on the Euronext Brussels exchange under the symbol OXUR. More information is available at . Important information about forward-looking statements Certain statements in this press release may be considered “forward-looking”. Such forward-looking statements are based on current expectations, and, accordingly, entail and are influenced by various risks and uncertainties. The Company therefore cannot provide any assurance that such forward-looking statements will materialize and does not assume an obligation to update or revise any forward-looking statement, whether as a result of new information, future events, or any other reason. Additional information concerning risks and uncertainties affecting the business and other factors that could cause actual results to differ materially from any forward-looking statement is contained in the Company’s Annual Report. This press release does not constitute an offer or invitation for the sale or purchase of securities or assets of Oxurion in any jurisdiction. No securities of Oxurion may be offered or sold within the United States without registration under the U.S. Securities Act of 1933, as amended, or in compliance with an exemption therefrom, and in accordance with any applicable U.S. state securities laws.