2021-09-17·Antimicrobial agents and chemotherapy2区 · 医学
In Vitro
Activity of APX2041, a New Gwt1 Inhibitor, and
In Vivo
Efficacy of the Prodrug APX2104 against Aspergillus fumigatus
2区 · 医学
Article
作者: Juvvadi, Praveen R. ; Shaheen, Shareef K. ; Asfaw, Yohannes G. ; Kapoor, Mili ; Shaw, Karen Joy ; Cole, D. Christopher ; Shwab, E. Keats ; Allen, John ; Steinbach, William J.
Invasive aspergillosis (IA) due to
Aspergillus fumigatus
is a deadly infection for which new antifungal therapies are needed. Here, we demonstrate the efficacy of a Gwt1 inhibitor, APX2041, and its prodrug, APX2104, against
A. fumigatus
.