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更新于：2025-03-20

Chloramphenicol/Fradiomycin Sulfate/Prednisolone

氯霉素/硫酸新霉素/泼尼松龙

更新于：2025-03-20

概要

基本信息

药物类型

小分子化药

别名

Chloramphenicol/Neomycin/Prednisolone、CHLOMYⓇ-P、HYSETIN-P

+ [2]

靶点

30S subunit

作用方式

抑制剂

作用机制

30S subunit抑制剂(30S核糖体亚基抑制剂)、蛋白质生物合成抑制剂

治疗领域

感染皮肤和肌肉骨骼疾病

在研适应症

皮肤和皮肤结构感染皮炎湿疹+ [2]

非在研适应症-

原研机构

Alfresa Pharma Corp.

在研机构

Alfresa Pharma Corp.

Fuji Chemical Industries Co., Ltd.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (1959-11-09),

皮炎湿疹脓皮症+ [1]

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C23H46N6O13

InChIKeyPGBHMTALBVVCIT-VCIWKGPPSA-N

CAS号119-04-0

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关联

100 项与氯霉素/硫酸新霉素/泼尼松龙相关的临床结果

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100 项与氯霉素/硫酸新霉素/泼尼松龙相关的转化医学

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100 项与氯霉素/硫酸新霉素/泼尼松龙相关的专利（医药）

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182

项与氯霉素/硫酸新霉素/泼尼松龙相关的文献（医药）

2024-07-02·International Journal of Neuroscience

Effects of protocatechuic acid against cisplatin-induced neurotoxicity in rat brains: an experimental study

Article

作者: Mert, Handan ; Mıs, Leyla ; Yıldırım, Serkan ; Mert, Nihat ; Kerem, Özge

Aims/Objectives: Cisplatin (CIS) is widely used in the treatment of various malignant tumors. The aim of study is to determine the potential protective effects of protocatechuic acid (PCA) on the brain in neurotoxicity induced by CIS in rats.Materials and methods: Forty rats were divided into four groups: 1-Control group: 2- PCA group: PCA was administered orally at a dose of 100 mg/kg/day for 5 weeks. 3-CIS group: 5 mg/kg/week of CIS was administered intraperiteonally 4-PCA + CIS group: The rats were given PCA orally daily for 5 weeks and CIS of 5 mg/kg/week. The brain tissues were used for histopathological examinations and for total antioxidant capacity (TAC), total oxidative state (TOS), oxidative stress index (OSI), tumornecrosis factor-alpha (T NF-α), interleukin 6 (IL-6) Interleukin 1 beta (IL-1β), acetylcholinesterase (AChE), glutamate, gamma aminobutyric acid (GABA), dopamine analyzes in ELISA. WBC, RBC, hemoglobin and hematocrit levels were measured.Results: PCA + CIS group compared to CIS group TOS, OSI, T NF-α, IL-6, IL-1β, AChE, glutamate, WBC levels decreased significantly, while TAC and GABA levels increased statistically significant. With this study, P CA corrected the deterioration in the oxidant / antioxidant status, suppressed neuro-inflammation, decreased AChE activity, partially normalized neurotransmitters, and decreased the increased WBC count. Necrosis seen in the CIS group in histopathological examinations was never seen in the PCA + CIS group.Conclusions: PCA may provide therapeutic benefit when used in conjunction with CIS.

2024-01-01·Integrative Zoology

Antifertility effects of EP‐1 (quinestrol and levonorgestrel) on Pacific rats (Rattus exulans)

Article

作者: Zhang, Zhibin ; Liu, Ming ; Tu, Feiyun ; Wang, Jichao ; Liu, Jing

AbstractPest rodents pose a serious threat to island biodiversity. Fertility control could be an alternative approach to control the impact of rodents on these islands. In this study, we examined the antifertility effects of EP‐1 baits containing quinestrol (E) and levonorgestrel (P) using a dose of 50 ppm E and P at three different ratios (E:P ratio = 1:2, 1:1, and 2:1) on Pacific rats (Rattus exulans) in the Xisha Islands, Hainan, China. Compared to the control group, all animals in EP‐1 treatment groups showed significantly decreased food intake and body weight. In treated males, there were obvious abnormalities in testis structure and a significant decrease of relative seminal vesicle weight, but no significant effect on relative uterine and ovarian weights (g kg−1 body weight), or ovarian structure in females. Adding 8% sucrose to the original 50‐ppm baits (E:P ratio = 1:1) significantly increased bait palatability for males and females. This dose induced uterine edema and abnormalities of ovarian structure in females but had no significant negative effect on the relative testis, epididymis, and seminal vesicle weights (g kg−1 body weight) or sperm density in males. In summary, 50‐ppm EP‐1 (1:1) baits have the potential to disrupt the fertility of females, and 8% sucrose addition to the EP‐1 baits (E:P ratio = 1:1) could improve bait palatability. This dose disrupted the testis structure in males. Future studies are needed to improve bait acceptance and assess the antifertility effects of EP‐1 (1:1) on Pacific rats in captive breeding trials and under field conditions.

2023-12-31·Journal of Oral Microbiology

Association of nine pathobionts with periodontitis in four South American and European countries

Article

作者: Mor, Carolina ; Àlvarez, Gerard ; Mendoza, Gerardo ; Huapaya, Enrique ; Isabal, Sergio ; Teughels, Wim ; Arredondo, Alexandre ; Nart, José ; León, Rubén ; Blanc, Vanessa ; Contreras, María José ; Isbej, Lorena ; Laleman, Isabelle

AimOur aim was to compare the prevalence and load of nine pathobionts in subgingival samples of healthy individuals and periodontitis patients from four different countries.MethodsFive hundred and seven subgingival biofilm samples were collected from healthy subjects and periodontitis patients in Belgium, Chile, Peru and Spain. The prevalence and load of Eubacterium brachy, Filifactor alocis, Fretibacterium fastidiosum, Porphyromonas endodontalis, Porphyromonas gingivalis, Selenomonas sputigena, Treponema denticola, Tannerella forsythia and Treponema socranskii were measured by quantitative PCR.ResultsThe association with periodontitis of all species, except for T. socranskii, was confirmed in all countries but Peru, where only P. endodontalis, P. gingivalis and T. denticola were found to be significantly associated. Moreover, most species showed higher loads at greater CAL and PPD, but not where there was BOP. Through Principal Component Analysis, samples showed clearly different distributions by diagnosis, despite observing a smaller separation in Peruvian samples.ConclusionsUnlike prevalence, relative load was found to be a reliable variable to discriminate the association of the species with periodontitis. Based on this, F. alocis, P. endodontalis, P. gingivalis, T. denticola and T. forsythia may be biomarkers of disease in Belgium, Chile and Spain, due to their significantly higher abundance in periodontitis patients.

100 项与氯霉素/硫酸新霉素/泼尼松龙相关的药物交易

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研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
皮肤和皮肤结构感染	日本	Fuji Chemical Industries Co., Ltd.	1994-03-15
皮炎	日本	Alfresa Pharma Corp.	1959-11-09
湿疹	日本	Alfresa Pharma Corp.	1959-11-09
脓皮症	日本	Alfresa Pharma Corp.	1959-11-09
继发感染	日本	Alfresa Pharma Corp.	1959-11-09

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASCO2020	N/A	HER2阳性乳腺癌新辅助	215	NACT+p+O	衊艱蓋遞蓋齋醖夢襯鹽(遞鏇艱廠餘鹽憲壓築願) = 積鬱衊膚膚簾鹹繭鹽鏇鬱簾蓋艱壓醖願夢鹹鹹 (淵簾構鑰顧襯獵淵製衊 ) 更多	积极	2020-05-25
ASCO2018	N/A	HER2阳性乳腺癌新辅助	219	NAC+T	(積蓋鏇廠壓獵繭壓構選) = 獵鹹選夢糧製壓鹽觸構繭積衊製製遞鏇顧齋蓋 (艱衊淵鹹簾窪觸糧窪餘 ) 更多	积极	2018-06-01
				NAC+T+P	(積蓋鏇廠壓獵繭壓構選) = 壓蓋繭糧範艱夢鏇淵襯繭積衊製製遞鏇顧齋蓋 (艱衊淵鹹簾窪觸糧窪餘 ) 更多
AACR2017	临床2期	转移性乳腺癌	81	Pelareorep + P	(選鹽觸壓醖窪糧簾範膚) = 膚糧醖醖範糧觸窪鬱壓憲範鹽顧願範襯鬱醖醖 (廠網鹽鏇鹹夢繭壓獵範 ) 更多	不佳	2017-07-01
				P	(選鹽觸壓醖窪糧簾範膚) = 餘繭遞廠壓觸淵淵網鏇憲範鹽顧願範襯鬱醖醖 (廠網鹽鏇鹹夢繭壓獵範 ) 更多
MOSG (ASCO2006)	临床3期	转移性乳腺癌	368	X+P	(鹽蓋遞網鹽範壓憲鏇艱) = PFS and OS are similar at a median follow-up of 15.5 months 窪願膚艱窪憲鬱蓋鬱膚 (顧築選蓋願網簾蓋觸蓋 ) 更多	-	2006-06-20
				X+T
ASCO2004	临床2期	非小细胞肺癌巩固	-	NVB oral + P	餘鑰壓網艱衊鑰鏇積構(醖壓遞構壓築糧遞鬱窪) = 窪鏇夢構夢夢簾範壓淵製簾襯艱窪淵淵顧選構 (願齋艱選製餘醖窪蓋憲 ) 更多	积极	2004-07-15
ASCO2004	N/A	局部晚期头颈部鳞状细胞癌新辅助	718	Regimen A: Ifosfamide	(製觸齋襯鑰築醖選窪艱) = 48.3% patients on D & 49.1% patients on E had grade III & IV neutropenia 選夢願簾醖齋鬱網積鏇 (選壓鏇襯鏇艱夢願淵構 ) 更多	-	2004-07-15
				Regimen B: Ifosfamide with cisplatin (I+P)