葡萄籽提取物(Grape Seed Extract)

概要

基本信息

药物类型

中药

别名

GSE、GSPE、Grape seed proanthocyanidin extrat

+ [2]

靶点-

作用机制-

治疗领域-

在研适应症-

非在研适应症-

原研机构-

在研机构

RDC Clinical Pty Ltd

非在研机构-

最高研发阶段临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

12

项与葡萄籽提取物相关的临床试验

NCT06440252 / Not yet recruiting临床3期

The Effectiveness of a Grape Seed Extract on Circulatory Measures in Healthy Adults: a Randomised, Double-blind, Placebo-controlled Crossover Study

This is a randomized, double-blind, placebo-controlled, 2 arm crossover study conducted over 11 weeks, with participants randomised to a product for 4 weeks, followed by a 3-week washout period before completing the second product for 4 weeks, to study the effectiveness of a grape seed extract on circulatory measures in healthy adults.

开始日期2024-06-30

申办/合作机构

RDC Clinical Pty Ltd

NCT06576700 / RecruitingN/AIIT

Effect of Procyanidins in the Leaky Gut Repairing Associated With Inflammatory Bowel Disease

The goal of this clinical trial is to learn if the Grape Seed Extract Ecovitis, featuring low monomeric catechins content and a high concentration of oligo-polymeric procyanidins, could modulate the Gut Microbiota composition of Ulcerative Colitis patients during the remission phase. The main questions it aims to answer are:
Does Ecovitis improve the microbiota composition in patients with Ulcerative colitis? Is the intestinal permeability affected? What about the variation in the quality of life?
Participants will:
Take 2 capsules/day of Ecovitis for eight weeks Visit the clinic two times for checkups, serum collection, and Questionaire.

开始日期2024-06-15

申办/合作机构

University of Padua

NCT04515004 / Recruiting临床2期

Leucoselect Phytosome for Neoadjuvant Treatment of Early Stage Lung Cancer

Lung cancer is the leading cause of cancer death in the country, surpassing deaths caused by colorectal, prostate and breast cancers combined. Veterans are at higher risk of lung cancer due to the higher rate of smoking and environmental toxin exposures. The lack of effective therapy for lung cancer provides the impetus to search for alternative, safe, and effective treatment agents to improve treatment strategy against lung cancer, enhance the probability of a cure and reduce recurrence. Based on encouraging preclinical and clinical findings from an early phase I lung cancer prevention study, using a special formulation of a standardized grape seed extract with enhanced absorption called leucoselect phytosome (LP), the purpose of this new CSR&D Merit Review project is to evaluate the potential usefulness of LP for pre-surgical treatment of early stage lung cancer patients in a phase IIa clinical trial. Findings from this study may set the stage for larger, confirmatory trials in the near future.

开始日期2023-09-18

申办/合作机构

VA Office of Research and Development

100 项与葡萄籽提取物相关的临床结果

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100 项与葡萄籽提取物相关的转化医学

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100 项与葡萄籽提取物相关的专利（医药）

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1,119

项与葡萄籽提取物相关的文献（医药）

2024-11-01·Science of The Total Environment

Spatiotemporally non-stationary evolution of groundwater levels in Poyang Lake Basin driven by meteorological and hydrological factors.

Article

作者: Qiu, Baozhong ; Lu, Chengpeng ; Liu, Bo ; Liu, Yu ; Chen, Jing ; Wang, Jianliang ; Wu, Chengcheng ; Shu, Longcang ; Zhang, Yong

The complex relationship between wet-dry transition in the Poyang Lake basin and groundwater storage significantly affects the lake's hydrology, downstream ecological state, and overall security along the Yangtze River in China. There is, however, a notable lack of systematic exploration into how various factors drive spatiotemporal variability in groundwater level (GWL). Using local indicators of spatial association (LISA), spatial non-stationarity models, and multi-source data, our analysis explores the spatial distribution of GWL and quantifies the influence of driving factors on its spatiotemporal non-stationarity at annual and monthly scales. We also compare driving factor contributions in hilly, plain, and local areas within the Poyang Lake basin. Our findings reveal significant local clustering of GWL, indicating substantial spatial autocorrelation and geographic heterogeneity in GWL. Influencing factors exhibit non-stationary effects on GWL at spatial and temporal scales, with precipitation (P), ground surface elevation (GSE), and soil moisture (SM) being primary contributors, generally exerting positive effects. SM contributes most during dry years and normal periods. P and the Palmer Drought Severity Index (PDSI) have greater impacts in hilly areas, while GSE shows the opposite trend. Rainfall is a source of groundwater recharge, with a lagged response observed in GWL to rainfall in this basin. The lag time is about 1-2 months. Evapotranspiration is not the dominant discharge pathway. The decrease in GWL during the dry season is mainly due to reduced precipitation recharge and increased lateral groundwater discharge from areas of high hydraulic head to areas of low hydraulic head.

2024-11-01·International Journal of Food Microbiology

Antimicrobial resistance induction potential of grapefruit seed extract on multi-species biofilm of E. coli in food industry

Article

作者: Kim, Unji ; Oh, Se-Wook

Biofilm formation in natural environments involving complex multi-structural arrangements hinders challenges in antimicrobial resistance. This study investigated the antimicrobial resistance potential of grapefruit seed extract (GSE) by examining the formation of mono-, dual-, and multi-species biofilms. We also explored the counterintuitive effect in response to GSE at various concentrations, including minimum inhibitory concentration (MIC) and sub-MIC (1/2 and 1/4 MIC). The results of the swimming and swarming motility tests revealed increased motility at the sub-MIC of GSE. The crystal violet assay demonstrated increased biofilm formation in multi-species biofilms, highlighting the synergistic effect of Escherichia coli, Salmonella Typhimurium, and Listeria monocytogenes. At the MIC concentration of GSE, field emission scanning electron microscopy (FE-SEM) revealed cell morphology damage, while sub-MIC increased biofilm formation and architectural complexity. Multi-species biofilms demonstrated greater biofilm-forming ability and antimicrobial resistance than mono-species biofilms, indicating synergistic interactions and enhanced resilience. These findings highlight the importance of understanding biofilm dynamics and antimicrobial resistance to ensure environmental safety.

2024-10-31·Animal Biotechnology

Effects of dietary supplementation of grape seed extract in comparison with excessive level of vitamin E on growth performance and antioxidant function of broilers

Article

作者: Zhou, Xiang ; He, Jian ; Liu, Hongwei ; He, Zongze ; Wang, Man ; Xiong, Zhaolong

The present study was carried out to evaluate the effects of dietary vitamin E (VE) or grape seed extract (GSE) on the growth performance and antioxidant function of broilers. Two hundred sixteen broiler chicks were randomly assigned to 3 diets: diet supplemented with oxidized rice bran oil (CN group), CN group with 25 mg/kg VE or 100 mg/kg GSE. Dietary VE or GSE improved the growth performance, reverted the disturbed levels of liver antioxidant enzymes, and reduced liver damage of broilers fed oxidized rice bran oil. The mRNA data showed that supplementation of VE or GSE enhanced the antioxidant capacity of the broiler liver through activation of the Keap1-Nrf2/ARE signaling pathway. The results suggested that VE and GSE can increase weight gain, improve the oxidative status, and alleviate liver injury in broiler chicken fed oxidized rice bran oil.

100 项与葡萄籽提取物相关的药物交易

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研发状态

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01267227 (CTgov)	临床2/3期	高脂血症 \| 应激氧化	80	Pterostilbene 125 mg twice daily (High Dose)	(艱製鏇網簾壓鏇壓選衊) = 積製積築遞網範簾鹽鹽淵鬱艱繭顧鏇鏇選鏇網 (構蓋願鏇範蓋範鏇鹹憲, 獵鹽觸壓鹽蓋窪憲糧膚 ~ 築獵膚艱簾鹹艱選鹽壓) 更多	-	2013-05-03
				Pterostilbene 50 mg twice daily (Low Dose)	(艱製鏇網簾壓鏇壓選衊) = 願觸願廠醖繭壓構鹹遞淵鬱艱繭顧鏇鏇選鏇網 (構蓋願鏇範蓋範鏇鹹憲, 齋鹹鹹糧膚顧構醖蓋鹹 ~ 網獵齋艱淵鹽遞襯蓋夢) 更多