This is a randomized, double-blind, placebo-controlled, 2 arm crossover study conducted over 11 weeks, with participants randomised to a product for 4 weeks, followed by a 3-week washout period before completing the second product for 4 weeks, to study the effectiveness of a grape seed extract on circulatory measures in healthy adults.

开始日期2024-10-31

申办/合作机构

RDC Clinical Pty Ltd

IRCT20240528061937N1

/ Recruiting临床3期IIT

Investigating the effect of Grape Seed on sperm parameters and sperm DNA fragmentation rate in infertile men

开始日期2024-08-07

申办/合作机构

Arak University of Medical Sciences

NCT06576700

/ RecruitingN/A

Effect of Procyanidins in the Leaky Gut Repairing Associated with Inflammatory Bowel Disease

The goal of this clinical trial is to learn if the Grape Seed Extract Ecovitis, featuring low monomeric catechins content and a high concentration of oligo-polymeric procyanidins, could modulate the Gut Microbiota composition of Ulcerative Colitis patients during the remission phase. The main questions it aims to answer are:
Does Ecovitis improve the microbiota composition in patients with Ulcerative colitis? Is the intestinal permeability affected? What about the variation in the quality of life?
Participants will:
Take 2 capsules/day of Ecovitis for eight weeks Visit the clinic two times for checkups, serum collection, and Questionaire.

开始日期2024-06-15

申办/合作机构

University of Padua

100 项与葡萄籽提取物相关的临床结果

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100 项与葡萄籽提取物相关的转化医学

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100 项与葡萄籽提取物相关的专利（医药）

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1,130

项与葡萄籽提取物相关的文献（医药）

2025-04-01·FISH PHYSIOLOGY AND BIOCHEMISTRY

Dietary grape seed extract mitigated growth retardation, hormonal delay, and gastrointestinal toxicity induced by insecticide imidacloprid in Nile tilapia

Article

作者: Abdelrazek, Heba M A ; Badawy, Lobna A ; El-Shenawy, Nahla S ; Fouad, Alyaa S ; El-Fahla, Nadia A ; Soliman, Mohamed T A ; Helmy, Seham A

Abstract:

Overusing the insecticide imidacloprid (IMD) in agriculture has led to its presence in water bodies, causing serious environmental issues and fish toxicity. This study explored the potential benefits of grape seed extract (GSE) in mitigating IMD-induced growth and hormonal and gastrointestinal toxicity in Nile tilapia. A total of 240 healthy juvenile tilapias Oreochromis niloticus (O. niloticus), weighing an average of 11.44 ± 2.01 g at 2 weeks of age, were divided equally into four groups, each with three replicates. The control group received no special treatment, while the second group was given a diet containing 2% GSE®. The third group was exposed to 1.5 µg IMD per liter of water. The fourth group was subjected to the same IMD exposure and fed a diet containing 2% GSE®. These treatments were administered continuously for 75 days. Growth indices, survival rate, biochemical parameters, and digestive enzymes were measured. In addition, the growth-related hormones, intestinal malondialdehyde (MDA), and catalase (CAT) were evaluated. Histological evaluations were conducted on the stomach, duodenum, ileum, and hepatopancreas, alongside body composition analysis. Exposure to IMD delayed growth, impaired serum biochemistry and digestive enzyme activity, altered body composition, obstructed hormonal responses, decreased CAT activity, and increased intestinal MDA. All tissues exhibited signs of degradation. Combining dietary GSE® with IMD improved the former parameters affected by IMD. In conclusion, research suggests that incorporating GSE® into the diet may help reduce the adverse effects of IMD exposure on Nile tilapia, presenting a promising opportunity to address the environmental impacts of insecticide contamination in aquatic ecosystems.Graphical Abstract

2025-03-01·MICROSCOPY RESEARCH AND TECHNIQUE

Effect of Dentin Bio‐Modifiers Grape Seed Extract, Hesperidin on Shear Bond Strength and Microleakage: A Scanning Electron Microscopic Assessment

Article

作者: Abrar, Eisha ; Alshehri, Faisal Hasan ; Qasim, Muhammad ; Al Wadei, Mohammed Hussain Dafer ; Alsaeed, Ali Y.

ABSTRACT:

Investigation of different collagen cross‐linking (CCL) agents, grape seed extract (GSE), Hesperidin (Hes), and rose bengal photosensitizer (RBP) on shear bond strength (SBS) and marginal leakage (ML) of composite bonded to carious affected dentin (CAD). Sixty‐eight human molars in which carious lesions up to the middle third of the dentin were included. CAD was made flat followed by acid etching. Teeth were allocated randomly into four groups based on the application of CCL agents. Group 1: no CCL agent, Groups 2–4 samples treated with CCL agents. Bonding of adhesive and composite was performed followed by artificial aging. ML assessment was performed using a dye penetration test. SBS was evaluated using a universal testing machine followed by failure mode analysis. Analysis of the resin CAD interface with SEM was performed to identify the resin tag. For group comparisons, one‐way ANOVA and post hoc Tukey test were used. The length and number of resin tags in GSE and Hes groups were greater than in the control and RBP. Furthermore, samples treated with GSE presented the highest scores of SBS and lowest ML. The control group presented the lowest bond integrity and highest ML. GSE and Hes positively influenced both SBS and ML.

2025-03-01·FOOD SCIENCE AND BIOTECHNOLOGY

Chitosan-sodium dodecyl sulfate nanoparticles: a promising approach for enhancing antibacterial activity against Streptococcus mutans of grapefruit seed extract

Article

作者: Cho, Eun Sung ; Lee, Hyeon Gyu ; Elbegbayar, Enkhtsatsral

In this study, grapefruit seed extract (GSE)-loaded nanoparticles (GNPs) were formed through ionic gelation between chitosan (CS) and sodium dodecyl sulfate (SDS) to improve antibacterial activity against oral bacteria, such as Streptococcus mutans, and to demonstrate the impact of particle size on antimicrobial activity. Particle size was negatively correlated with the antibacterial effect; the smaller GNPs showed significantly higher antimicrobial activity than the other particles. The optimal formulation of the smaller GNPs was determined using response surface methodology (RSM). The optimized GNPs improved antibacterial activity, which was approximately 3.5 times higher than that of free GSE (p < 0.05). Moreover, the GNPs were effective at reducing bacterial growth, achieving a reduction of more than 3 log₁₀ CFU/mL within the first 3 h and complete inhibition of bacterial growth after 9 h. This study suggests that nanoencapsulation significantly enhances its antibacterial activity against oral bacteria.

项与葡萄籽提取物相关的新闻（医药）

2021-01-26

·BioSpace

New Study Concludes Xlear Kills and/or Deactivates SARS-CoV-2; Efficacy Against New Variants

Jan. 26, 2021 09:15 UTC EVANSTON, Ill.--(BUSINESS WIRE)-- A new in vitro study done collaboratively by Utah State University and Northwestern University finds Xlear components (grapefruit seed extract and xylitol) significantly eliminates SARS-CoV-2, the virus that causes COVID-19. The imaging research study component was performed at the BioCryo facility of Northwestern University’s NUANCE Center. This press release features multimedia. View the full release here: Using electron microscopy, we have visual evidence showing that xylitol and grapefruit seed extract (GSE) counters the virus. The GSE kills the virus, while the xylitol prevents the virus from attaching to the cell walls. The image shows SARS-CoV-2 viruses outside the cell and never attached, thereby preventing infection (Photo: Business Wire) The study tested SARS-CoV-2 virus titers and LRV against a single concentration of Xlear nasal spray. According to the Study, “After a 25-minute contact time, the nasal spray reduced virus from 4.2 to 1.7 log10 CCID50 per 0.1 mL, a statistically significant reduction (P<0.001) of 2.5 log10 CCID50.” The Northwestern/Utah State Study is the newest in a string of studies to reach the conclusion that Xlear is effective against the SARS-CoV-2. However, the study breaks new ground in two vital respects: “First, we conclude, in addition to countering SARS-CoV-2, Xlear is likely effective in preventing the spread of future H1N1 viruses, including the emerging SARS-CoV-2 variants, along with other viral epidemics. Given the more transmissible variants we now face, this is critical now,” said Professor Mark Cannon, Feinberg School of Medicine, Northwestern University. “Second, using electron microscopy, we have visual evidence showing that xylitol and GSE counters the virus. The GSE kills the virus, while the xylitol prevents the virus from attaching to the cell walls. The image (attached) shows SARS-CoV-2 viruses outside the cell and never attached, thereby preventing infection,” added Dr. Cannon. The study postulates that xylitol acts as a decoy target for SARS-CoV-2, preventing virus attachment to the core protein on the cell wall. The collaborative study concludes: “Because there are no risk factors in using the X/GSE combination therapy, and [Xlear] nasal spray is over the counter available without prescription, and [Xlear] allows for comfortable long term mask wearing, adoption of this preventive anti-viral therapy should be encouraged.” Full study: For more information on Xlear (including where to obtain): View source version on businesswire.com: Contacts Jeff Gulko 617.304.7339 jeff@thegulkogroup.com Source: Xlear Smart Multimedia Gallery Photo Using electron microscopy, we have visual evidence showing that xylitol and grapefruit seed extract (GSE) counters the virus. The GSE kills the virus, while the xylitol prevents the virus from attaching to the cell walls. The image shows SARS-CoV-2 viruses outside the cell and never attached, thereby preventing infection (Photo: Business Wire) View this news release and multimedia online at:

100 项与葡萄籽提取物相关的药物交易

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适应症	最高研发状态	国家/地区	公司	日期
乳腺癌	临床2期	美国	City of Hope National Medical Center	2006-04-15
溃疡性结肠炎	临床前	中国	南通大学	2024-01-11
结直肠癌	临床前	美国	University of Colorado Denver	2008-05-01

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01267227 (CTgov)	临床2/3期	高脂血症 \| 应激氧化	80	Pterostilbene 125 mg twice daily (High Dose)	鏇蓋壓觸製積齋鹹糧築(憲糧鏇範獵遞簾積築壓) = 鏇觸衊艱夢簾鑰製廠膚觸壓糧鏇襯構壓夢選網 (窪願齋範衊衊鹽糧願獵, 構齋築鑰遞窪膚鬱觸積 ~ 鹹鬱鹽鏇糧鹽糧網獵憲) 更多	-	2013-05-03
				Pterostilbene 50 mg twice daily (Low Dose)	鏇蓋壓觸製積齋鹹糧築(憲糧鏇範獵遞簾積築壓) = 製願簾膚鑰簾築餘積憲觸壓糧鏇襯構壓夢選網 (窪願齋範衊衊鹽糧願獵, 蓋願艱構觸遞觸衊餘簾 ~ 獵願獵鏇衊鹹範淵廠獵) 更多