Among various pharmaceutical pollutants, fluoroquinolones broad-spectrum antibiotics are major water pollutants, usually present in the aquatic environment as multicomponent mixtures with potentially deleterious effects on humans and the environment. This study used electrochemical oxidation to remove ofloxacin from aqueous solution using Ti and IrO₂-RuO₂-TiO₂/Ti electrodes as cathode and anode, respectively. We investigated the morphology and electrochemical behavior of the selected anode and analyzed the effects of operational variables on the degradation performance of OFL in detail. The results showed that the electrochemical system for degrading OFL possessed high oxidizing activity and excellent durability, and the hydroxyl and reactive chlorine radicals generated by the electrochemical reaction could effectively degrade OFL. As predicted and optimized by the PSO-SVR model, the removal of OFL could be increased to 99.011 % when the electrolyte concentration was 5.65 mM, current density was 3.9 mA/cm², initial pH was 7.12, and treatment time was 3.7 min. In addition, four possible degradation pathways, including ring opening and mineralization, were proposed based on the byproducts calculated by DFT and determined by GC-MS. More importantly, this electrochemical process can efficiently degrade various organic pollutants (ciprofloxacin, enrofloxacin, sulfamethoxazole, oxytetracycline, and chloromycetin). This study provides the theoretical basis and essential data for applying this electrochemical system in wastewater treatment.

2024-05-20·ACS applied bio materials

Selective Bacterial Growth Inactivation by pH-Sensitive Sulfanilamide Functionalized Carbon Dots

Article

作者: Dutta, Tanmay ; Lzaod, Stanzin ; Mishra, Anurag ; Bhattacharya, Sagarika

Carbon dots (CDs) were synthesized hydrothermally by mixing citric acid (CA) and an antifolic agent, sulfanilamide (SNM), employed for pH sensing and bacterial growth inactivation. Sulfanilamide is a prodrug; aromatic hetero cyclization of the amine moiety along with other chemical modifications produces an active pharmacological compound (chloromycetin and miconazole), mostly administered for the treatment of various microbial infections. On the other hand, the efficacy of the sulfanilamide molecule as a drug for antimicrobial activity was very low. We anticipated that the binding of the sulfanilamide molecule on the carbon dot (CD) surface may form antibacterial CDs. Citric acid was hybridized with sulfanilamide during the hydrothermal preparation of the CDs. The molecular fragments of bioactivated sulfanilamide molecule play a crucial role in bacterial growth inactivation for Gram-positive and Gram-negative bacteria. The functional groups of citric acid and sulfanilamide were conserved during the CD formation, facilitating the zwitterionic behavior of CDs associated with its photophysical activity. At low concentrations of CDs, the antibacterial activity was apparent for Gram-positive bacteria only. This Gram-positive bacteria selectivity was also rationalized by zeta potential measurement.

2023-08-01·European journal of medicinal chemistry

Thiazolyl hydrazineylidenyl indolones as unique potential multitargeting broad-spectrum antimicrobial agents

Article

作者: Zhou, Cheng-He ; Xu, Jia-He ; Tangadanchu, Vijai Kumar Reddy ; Zhao, Wen-Hao

The emergence of pathogenic and drug-resistant microorganisms seriously threatens public safety. This work constructed a unique type of thiazolyl hydrazineylidenyl indolones (THIs) to combat global microbial multidrug-resistance. Bioactive evaluation discovered that some target THIs displayed much superior antimicrobial efficacy than clinical chloromycetin, norfloxacin, cefdinir or fluconazole against the tested strains. Eminently, butyl THI 6c displayed a broad antimicrobial spectrum with low MICs of 0.25-1 μg/mL. The highly active THI 6c not only showed low cytotoxicity and hemolysis, rapidly bactericidal ability, good antibiofilm activity and promising pharmacokinetic properties, but also could significantly impede the development of bacterial resistance. Preliminary exploration of antibacterial mechanism revealed that THI 6c could effectively penetrate the cell membrane of MRSA and embed DNA to form 6c‒DNA supramolecular complex and thus hinder DNA replication. Moreover, THI 6c could reduce cell metabolic activity, which might be attributed to the fact that THI 6c could target the pyruvate kinase of MRSA and interfere with the function of the enzyme. These results provided powerful information for further developing thiazolyl hydrazineylidenyl indolones as new broad-spectrum antimicrobial agents.

100 项与 Chloramphenicol Sodium Succinate 相关的药物交易

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