Hepatitis B vaccine(Vaxine Pty Ltd.)(Hepatitis B vaccine(Vaxine Pty Ltd.)) - 药物靶点：HBsAg_在研适应症：乙型肝炎_专利_临床

概要

基本信息

药物类型

预防性疫苗

别名

Hepadvax、Hepatitis B vaccine、PreS-HBsAg

靶点

HBsAg

作用方式

抑制剂

作用机制

HBsAg抑制剂(HBV表面抗原抑制剂)

治疗领域

在研适应症

非在研适应症

原研机构

在研机构

非在研机构-

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

2

项与 Hepatitis B vaccine(Vaxine Pty Ltd.) 相关的临床试验

NCT03038802

/ Not yet recruiting临床1/2期

A Randomised Controlled Phase 1 Study of Vaccine Therapy for Control or Cure of Chronic Hepatitis B Virus Infection

This is a pilot study to determine the safety and efficacy of a novel adjuvanted hepatitis B virus (HBV) vaccine formulated as a potential therapeutic vaccine against chronic HBV infection. An ongoing human clinical trial of this HBV vaccine in a prophylactic setting has confirmed this vaccine to be more effective at inducing seroconversion as measured by development of Hepatitis B surface antibody (HBsAb) in poor responder subjects than the standard alum-adjuvanted HBV vaccine, providing promise that this new vaccine may also be able to induce HBV viral control and/or seroconversion in chronically infected subjects

开始日期2024-09-30

申办/合作机构

Vaxine Pty Ltd.

NCT01951677

/ Completed临床1期

Phase 1 Randomized, Controlled, Double-blind Study to Compare the Safety and Effectiveness of Hepatitis B Vaccines in Individuals With Renal Impairment, Diabetes Mellitus or Age Greater Than 40 Years

There is a need for more effective and better-tolerated hepatitis B vaccines for low responder high-risk populations including patients with renal impairment and/or diabetes mellitus and those aged over 40 years. Several approaches are available to enhance the potency of hepatitis B virus vaccines including use of the more highly immunogenic antigens, replacing alum with potentially more effective adjuvants, and increasing the dose of vaccine antigen. A combination of these strategies is being tested in this study to identify the most promising candidate approaches to take forward into advanced clinical development

开始日期2013-07-01

申办/合作机构

Vaxine Pty Ltd.

[+1]

100 项与 Hepatitis B vaccine(Vaxine Pty Ltd.) 相关的临床结果

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100 项与 Hepatitis B vaccine(Vaxine Pty Ltd.) 相关的转化医学

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100 项与 Hepatitis B vaccine(Vaxine Pty Ltd.) 相关的专利（医药）

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100 项与 Hepatitis B vaccine(Vaxine Pty Ltd.) 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB11627

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
乙型肝炎	临床2期	-	Vaxine Pty Ltd.	-
慢性乙型肝炎	临床前	澳大利亚	Vaxine Pty Ltd.	2017-01-30
糖尿病	临床前	澳大利亚	Vaxine Pty Ltd.	2013-07-01