Combining porous starch and polyoxyethylene hydrogenated castor oil RH40 to enhance the solubility, stability, and bioavailability of bisdemethoxycurcumin

Article

作者: Ma, Zhongyi ; Du, Yan ; Duan, Xuehui ; Liang, Xuewei ; Tang, Yixuan ; Yang, Andong ; Tang, Zhongjie ; Zhu, Ning

Bisdemethoxycurcumin (BDC) is an important ingredient derived from the food spice turmeric. Although BDC exhibits various pharmacological effects, it is characterized by poor water solubility and limited stability under light. Considering that the high specific surface area of porous starch (PS) renders it an ideal carrier for the encapsulation of active compounds, and polyoxyethylene‑hydrogenated castor oil RH40 (RH40) is an effective solubilizer for BDC, the current study optimized the PS/RH40/BDC formulation to combine these advantages. Consequently, a PS/RH40/BDC ratio of 10:3:1 was identified as optimal (RH-PS/BDC). Characterization using scanning electron microscopy, X-ray diffractometry, Fourier-transform infrared spectroscopy, Brunauer-Emmett-Teller analysis, and stability testing indicated that BDC was amorphously encapsulated within the RH-PS system, thereby leading to enhanced stability and solubility. Furthermore, cellular uptake experiments revealed a significant increase of RH-PS/BDC. In terms of the enhancement mechanism, RH40 can reduce cell membrane fluidity and open tight junctions between intestinal epithelial cells, thereby facilitating BDC absorption. In vivo pharmacodynamic analysis confirmed that RH-PS/BDC effectively inhibited LPS-induced cerebral neuritis. Overall, this study demonstrates the role of PS in combination with RH40 in enhancing the stability and bioavailability of BDC. This simple and efficient preparation strategy is promising for future research and product development.

2025-05-01·Food Hydrocolloids

Investigating curcuminoid encapsulation in β-cyclodextrin: Insights from NMR spectroscopy and MD simulations

作者: Ansari, Suleman Jalilahmad ; Chaudhari, Sachin R. ; Mogurampelly, Santosh ; Biswas, Anisha ; Dandamudi, Usharani ; Naresh, K. S.

Curcuminoids, key bioactive compounds in turmeric, exhibit significant health benefits but suffer from poor bioavailability, limiting their therapeutic potential.Cyclodextrin (CD) encapsulation is a promising strategy to enhance bioavailability, yet studies primarily focus on curcumin (CUR), with limited exploration of other major curcuminoids such as demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC).This study provides a comprehensive comparative anal. of the encapsulation behavior of CUR, DMC, and BDMC within β-cyclodextrin (β-CD) using a combination of phase solubility anal., NMR spectroscopy (1D-¹H NMR, 2D-NOESY and DOSY), and mol. dynamics (MD) simulations. ¹H NMR, NOESY spectra and diffusion studies revealed the strongest inclusion complex formation for BDMC, confirmed by phase stability constants (K).Mol. dynamics simulations further quantified the interaction strength through radial distribution functions (RDFs), close contact analyses, and hydrogen bonding patterns, highlighting the absence of -OCH₃ groups in BDMC as a key factor for enhanced interaction.These findings provide crucial mechanistic insights into curcuminoids encapsulation, suggesting BDMC as a superior candidate for β-CD formulations, with implications for developing more effective nutraceutical and drug delivery systems.

2025-05-01·Food Chemistry

Unleashing the nutritional potential of Brassica microgreens: A case study on seed priming with Vermicompost

Article

作者: Capri, Ettore ; Zengin, Gokhan ; García-Pérez, Pascual ; Lucini, Luigi ; De Gregorio, Marco A

Microgreens constitute ready-to-eat functional foods, being rich sources of phytonutrients and phytochemicals. Because of their short life cycle, seed priming is a promising strategy to fortify their functional outcome. Vermicompost was applied as seed priming agent for four Brassicaceae microgreens of nutritional interest. The combination of untargeted metabolomics and in vitro assays highlighted the involvement of phenolics and glucosinolates in the functional traits of microgreens, following species-specific responses. Cress accumulated specific polyphenols at low vermicompost dosage, while daikon mainly accumulated aliphatic glucosinolates. Mustard and red cabbage were found to repress glucosinolate accumulation while eliciting polyphenols following vermicompost fortification. The application of machine learning chemometrics revealed that both families of compounds coordinated the functionality of microgreens in terms of antioxidant and neuroprotective bioactivities, highlighting the importance of optimizing genotype-specific interventions. This research sheds light on nutritional enhancement of functional foods, paving the way toward the establishment of novel sustainable food systems.

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适应症	最高研发状态	国家/地区	公司	日期
骨关节炎	临床前	中国	温州医科大学	2024-02-27
前列腺癌	临床前	中国	China Center for Pharmaceutical International Exchange (CCPIE)	2024-01-01
类风湿关节炎	临床前	中国	烟台毓璜顶医院（青岛大学附属烟台毓璜顶医院）	2024-01-01