Background. Psoriasis is a chronic noncommunicable dermatological condition, and psoriasis vulgaris is the most common phenotype. Acitretin is the most widely used systemic retinoid in the treatment of psoriasis. This review evaluates the clinical therapeutic effects of Xiaoyin granule, a Chinese herbal medicine, combined with acitretin capsule in the treatment of psoriasis vulgaris. Methods. Six databases including PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), Wan Fang, and China Biology Medicine disc (CBM) were searched for published studies on Xiaoyin granule and/or acitretin capsule in psoriasis vulgaris. The Cochrane Collaboration risk-of-bias instrument was used to assess the quality of the included RCTs. STATA 14.0 was used to conduct the statistical analysis. Results. Twenty-eight trials with 3281 patients were included in this meta-analysis. The results of this study show that the combined treatment of Xiaoyin granule and acitretin capsule could improve the total effective rate (TER) and cure rate (CR) when compared with acitretin capsule (TER:

RR = 1.15

, 95% CI (1.10, 1.21); CR:

RR = 1.8

, 95% CI (1.62, 2.00)) or Xiaoyin granule (TER:

RR = 1.24

, 95% CI (1.11, 1.39); CR:

RR = 1.75

, 95% CI (1.54, 1.98)) alone. The combined therapy could decrease the PASI score (mean

difference = - 1.45

, 95% CI (-2.09, -0.80)) and inhibit inflammation (IL-10: mean

difference = 1.16

, 95% CI (0.94, 1.38); IL-17: mean

difference = - 2.06

, 95% CI (-2.60, -1.51)) in psoriasis vulgaris patients. Conclusions. The combination of Xiaoyin granule and acitretin capsules could be a novel therapeutic strategy in the treatment of psoriasis vulgaris. However, the quality of trials in this study limited the conclusion, and more high-quality RCTs are needed for further evaluation.

2022-03-07·Computational and Mathematical Methods in Medicine4区 · 工程技术

Reconstruction Algorithm-Based Computed Tomography Image Feature for Evaluating the Effect of Internal Administration and Medicated Bath of Liangxue Xiaoyin Decoction on Psoriasis Vulgaris

4区 · 工程技术

ArticleOA

作者: Zhang, Fang ; Zou, Jili ; Huang, Dandan

Skin computed tomography (CT) image based on improved marching cubes (MC) algorithm was explored to evaluate the therapeutic effect of internal administration of Liangxue Xiaoyin decoction combined with medicated bath in the treatment of psoriasis vulgaris. 712 patients with psoriasis vulgaris blood heat syndrome in hospital were recruited as the research object, which were randomly divided into observation group (TCM oral therapy combined with medicinal bath) and control group (TCM oral therapy), each with 356 cases. Psoriasis area and severity index (PASI), pruritus degree, and clinical treatment effect were compared. The results showed that the reconstruction time of median method was greatly shorter, and the algorithm efficiency was improved by 40.6290%. After treatment, the psoriasis area and severity index (PASI) score of the observation group was

5.61 \pm 1.15

Δ PASI = (22.64 \pm 2.15)

Δ PASI % = 80.14 %

, which were greatly higher than the control group ((

9.41 + 1.56

) points,

Δ PASI = (18.84 + 1.65)

points,

Δ PASI % = 66.69 %

) (

P < 0.05

). After treatment, the itching degree of the observation group was

3.03 \pm 1.01

points, which was lower than that of the control group ((

3.71 \pm 1.06

) points), and the itching degree of the observation group was greater than that of the control group, with substantial difference (

P < 0.05

). The total effective rate of observation group (88.76%) was higher than that of control group (71.07%) (

P < 0.05

). Therefore, skin CT image based on the improved MC algorithm can evaluate the therapeutic effect of internal administration of Liangxue Xiaoyin decoction combined with medicated bath in the treatment of psoriasis vulgaris. The internal administration of Liangxue Xiaoyin decoction combined with medicated bath had a good effect on the treatment of psoriasis vulgaris and was of certain clinical application value.

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