Two steroidal glycosides, PO-1 and PO-2, were tested as a new hypoglycemic drug. PO-2 showed remarkable hypoglycemic activity on i.p. injection into normal mice. PO-1 slightly lowered the blood glucose in normal mice. Furthermore, PO-1 and PO-2 exhibited significant hypoglycemic effects in streptozotocin-induced diabetic mice. However, a steroid, diosgenin, did not affect the blood glucose level in either normal or streptozocin-induced diabetic mice, indicating that the branching glucose units are essential for the biological activity.

1979-08-01·Immunology

Mitogenic proteins of pokeweed. II. The differentiation of human peripheral blood B lymphocytes stimulated with purified pokeweed mitogens (Po-2 and Po-6) from pokeweed, Phytolacca octandra.

Article

作者: Bodger, M P ; Fitzgerald, P H ; McGiven, A R

Purified pokeweed mitogens, Po-2 and Po-3, extracted from Phytolacca octandra, stimulated plasma cell formation in cultures of human peripheral blood lymphocytes. Plasma cell formation did not occur in cultures of purified B cells but was dependent on T-cell help. High T-cell numbers, however, suppressed plasma cell formation in mixed B- and T-cell cultures stimulated with Po-2. T-cell helper function was exerted across a major histocompatibility barrier and was not dependent on T-cell proliferation. Soluble helper factor(s) from activated T cells were not demonstrated. Po-3 was an effective B-cell stimulant only at concentrations between 0.1 and 1.0 micrograms/ml. In contrast, relatively high concentrations of Po-2 (50--100 micrograms/ml) were required to induce B-cell differentiation. More plasma cells were generated in Po-2-stimulated cultures than in Po-3-stimulated cultures and this was thought to reflect the more aggregated state of Po-2.

Pediatrie

Les détresses respiratoires du nouveau-né: étude de la PaO2, indications thérapeutiques.

Article

作者: Badonnel, Y ; Vert, P ; Neimann, N ; Marchal, C ; Pierson, M ; Crance, J P

100 项与 PO-02 相关的药物交易

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