To determine whether transcranial 2-MHz ultrasound combined with intravenous administration of microbubbles improves early recanalization in patients with acute ischemic stroke caused by middle cerebral artery (MCA) proximal occlusion treated with intravenous alteplase within 3 hours of symptom onset.

开始日期2004-06-01

申办/合作机构

Toulouse University Hospital

100 项与 Palmitic acid-stabilized galactose-based air microbubbles 相关的临床结果

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100 项与 Palmitic acid-stabilized galactose-based air microbubbles 相关的转化医学

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100 项与 Palmitic acid-stabilized galactose-based air microbubbles 相关的专利（医药）

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项与 Palmitic acid-stabilized galactose-based air microbubbles 相关的文献（医药）

2024-02-01·Computer methods and programs in biomedicine

A novel gas embolotherapy using microbubbles electrocoalescence for cancer treatment

Article

作者: Mojra, Afsaneh ; Sormoli, Hossein Azizi ; Heidarinejad, Ghassem

BACKGROUND AND OBJECTIVE:

Embolotherapy has been increasingly used to disrupt tumor growth. Despite its success in the occlusion of microvessels, it has drawbacks such as limited access to the target location, limited control of the blocker size, and inattention to the tumor characteristics, especially high interstitial fluid pressure. The present work introduces a novel numerical method of gas embolotherapy for cancer treatment through tumor vessel occlusion.

METHODS:

The gas microbubbles are generated from Levovist bolus injection into the tumor microvessel. The microbubble movement in the blood flow is innovatively controlled by an electric field applied to the tumor-feeding vessel. The interaction between the Levovist microbubbles and the electric field is resolved by developing a fully coupled model using the phase-field model, Carreau model for non-Newtonian blood, Navier-Stokes equations and Maxwell stress tensor. Additionally, the critical effect of high interstitial fluid pressure as a characteristic of solid tumors is included.

RESULTS:

The findings of this study indicate that the rates of microbubble deformation and displacement increase with the applied potential intensity to the microvessel wall. Accordingly, the required time for a microbubble to join the upper microvessel wall reduces from 1.97ms to 22 μs with an increase of the electric potential from 3.5V to 12.5V. Additionally, an electric potential of 12.5V causes the microbubbles coalescence and formation of a gas column against the bloodstream.

CONCLUSIONS:

Clinically, our novel embolization procedure can be considered a non-invasive targeted therapy, and under a controlled electric field, the blocker size can be precisely controlled. Also, the proposed method has the potential to be used as a gradual treatment in advanced cancers as tumors develop resistance and relapse.

2022-04-01·European journal of radiology2区 · 医学

Diagnostic accuracy of contrast-enhanced ultrasound to differentiate benign and malignant breast lesions: A systematic review and meta-analysis

2区 · 医学

Review

作者: Cheng, Jia ; Wang, Jing ; Zhao, Rui

OBJECTIVE:

To evaluate the pooled diagnostic accuracy of contrast-enhanced ultrasound (CEUS) to differentiate benign and malignant breast lesions.

MATERIALS AND METHODS:

Electronic databases of PubMed, Embase, and the Cochrane Library were searched for potentially eligible studies throughout January 2022. The potential effects of publication year, country, mean age, and contrast agents on the diagnostic accuracy of CEUS were also assessed.

RESULTS:

Twenty-nine studies involving 3050 lesions were selected for the meta-analysis. The pooled sensitivity and specificity for CEUS diagnosing malignant breast lesions were 0.87 [95% confidence intervals (CI), 0.81-0.90] and 0.79 (95% CI, 0.73-0.84), respectively. The positive and negative likelihood ratios were 4.17 (95% CI, 3.21-5.42) and 0.17 (95% CI, 0.12-0.24), respectively. The summary diagnostic odds ratio of CEUS to differentiate benign and malignant breast lesions was 20.55 (95% CI, 14.11-29.93), and the Lambda of CEUS for detecting malignant breast lesions was 3.18 (95% CI, 2.71-3.64). Subgroup analyses showed that patients' age and contrast agents (Levovist, SonoVue, or other) might affect the diagnostic accuracy of CEUS used to differentiate benign and malignant breast lesions.

CONCLUSIONS:

CEUS had a relatively high diagnostic accuracy to differentiate benign and malignant breast lesions. Moreover, the diagnostic value of CEUS in younger patients or those using SonoVue as contrast agents was higher than that in the corresponding subgroups.

2019-02-01·Journal of pediatric urology4区 · 医学

The evaluation of vesicoureteral reflux among children using contrast-enhanced ultrasound: a literature review

4区 · 医学

Review

作者: Ming, J M ; Lopes, R I ; Chua, M E ; Lorenzo, A J ; Mendoza, J S ; Fernandez, N ; Marson, A ; Kim, J K ; Takahashi, M S

INTRODUCTION:

Voiding cystourethrogram (VCUG) with fluoroscopy remains the gold standard for detection and evaluation of vesicoureteral reflux (VUR) among children. However, the ionizing radiation exposure remains a concern for this diagnostic modality. Recent studies have proposed using contrast-enhanced ultrasound as an alternative option for VUR screening and follow-up in children. The aim of the study was to review the literature of comparative studies that assessed the diagnostic accuracy of contrast-enhanced ultrasound compared with VCUG.

METHODOLOGY:

A systematic literature search was performed on electronic medical literature databases in July 2017. Literature identification, screening, and assessment of eligibility were performed by five reviewers with a pediatric radiologist. Literature was summarized for the study population, contrast used, and ultrasound mode as well as the timing of comparative reference study being performed. The studies were clustered according to the kind of contrast used. Reported diagnostic accuracy was extracted from individual studies and summarized across the included studies using descriptive statistics of median and interquartile range (IQR).

RESULT:

A total of 45 comparative studies were identified as eligible for the summary of the literature. Two generations of ultrasound contrast were identified in the available studies (first generation, Levovist and second generation, SonoVue). For the ultrasound studies using the first-generation contrast, the median sensitivity, regardless of the ultrasound mode, was 90.25 (IQR 83.25-97), and the median specificity was 93 (IQR 91.3-95.25). Among studies using the second-generation contrast, the median sensitivity was 86.26 (IQR 81.13-97), and the median specificity was 90.99 (IQR 84-98). No serious adverse events were reported in any of the studies.

CONCLUSION:

Overall, this review highlights the application of contrast-enhanced ultrasound for its advantage of no exposure to ionizing radiation and diagnostic accuracy relatively comparable to VCUG in the evaluation of VUR. In addition to the functional evaluation of the VUR, it also provides an anatomic evaluation of the kidneys and bladder with ultrasound imaging. However, one should also note that this alternate procedure is highly operator dependent where diagnostic accuracy is excellent when the expertise is available.

项与 Palmitic acid-stabilized galactose-based air microbubbles 相关的新闻（医药）

2024-06-15

·医药地理

【好文推荐】微泡超声造影剂的研究与应用概况

未经授权，不得转载微泡超声造影剂的研究与应用概况 Research and Application of Microbubble Ultrasound Contrast Agents 闫梦1，何朝星1，李凤2，王岳恒3，向柏1*，邵娟4* (1. 河北医科大学药学院药剂学教研室，河北石家庄 050017；2. 河北医科大学第二医院腹部超声科，河北石家庄 050017；3. 河北医科大学第二医院心脏超声科，河北石家庄 050017；4. 河北医科大学第三医院老年病科，河北石家庄 050017) 摘要由于超声成像具有非侵入性、相对简便、无电离辐射等特点，已被广泛用于各个领域。超声造影剂在超声成像中发挥着重要作用，通常由软壳或硬壳材料组成，尺寸从纳米到微米不等，功能从最初的成像诊断发展成诊断、治疗一体化模式。部分上市的超声造影剂( 例如Levovist®、Optison®、Definity® 和Sonovue®) 已在欧洲、亚洲等地区用于临床超声检查。该综述重点介绍了微泡超声造影剂的研究进展及其临床应用，以期为新型超声造影剂的开发提供参考。关键词超声成像；超声造影剂；微泡；临床应用以下为文章节选超声成像作为一种无创、较为方便、无辐射伤害的诊疗方法，具有成像速度快、可实时成像等优点，已在妇产科、心血管、眼科、消化系统等领域中被广泛应用[1]。该技术通过传感器收集在组织中传播、反射、吸收后的超声波，并生成相应图像[2]。然而，在人体内环境中，病变部位与器官或组织之间的密度差并不足以产生清晰的超声图像，需要给患者静脉或局部注射高阻抗物质，即超声造影剂(ultrasound contrast agent，UCA)，用于改善器官成像[3]。目前，超声造影剂通常是直径为1 ～ 10 μm 的微气泡(microbubbles，MBs)[4]，由不同的外壳封装得到；外壳可增加MBs 的循环时间和耐久性，同时降低气核的释放速率。随着分子材料学的发展，近年来涌现了众多针对MBs 外壳材料的研究[5]。本综述基于造影剂的发展，介绍微泡超声造影剂的研究进展以及临床应用。 ↑长按二维码阅读全文基金项目：国家自然科学基金资助项目(81973251)、河北省自然科学基金资助项目(H2019206445)、河北省2021 年度医学科学研究课题(20211108) 作者简介：闫梦(1999—)，女，硕士研究生，专业方向：新型纳米药物递送系统。通信作者：向柏(1978—)，男，博士，教授，从事新型纳米载体在疾病诊疗中的应用研究。 E-mail：baixiang@hebmu.edu.cn 邵娟(1981—)，女，硕士，副主任医师，从事糖尿病、内分泌疾病等研究。 E-mail：sjyx1981@163.com 文章详情欢迎登录《中国医药工业杂志》官网查看。 END 如需获取更多数据洞察信息或公众号内容合作，请联系医药地理小助手微信号：pharmadl001

临床研究疫苗诊断试剂

100 项与 Palmitic acid-stabilized galactose-based air microbubbles 相关的药物交易

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