PFP-6 (University of Vienna)(PFP-6 (University of Vienna))

概要

基本信息

药物类型

小分子化药

别名

GP-388、PFP 6

靶点-

作用方式-

作用机制-

治疗领域

肿瘤

在研适应症-

非在研适应症

肿瘤

原研机构

University of Vienna

在研机构-

非在研机构

University of Vienna

最高研发阶段无进展药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 PFP-6 (University of Vienna) 相关的临床结果

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100 项与 PFP-6 (University of Vienna) 相关的转化医学

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100 项与 PFP-6 (University of Vienna) 相关的专利（医药）

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1

项与 PFP-6 (University of Vienna) 相关的文献（医药）

1996-05-01·Biomedical Chromatography4区 · 医学

Determination of the New MDR-Modifier PFP 6 and its Metabolites in Human Liver Microsomes by High-Performance Liquid Chromatography

4区 · 医学

Article

作者: Walter Jäger ; Margit Spatzenegger ; Gerhard Ecker

A specific and sensitive method for the determination of PFP 6, a new compound for reverting multidrug resistance, and its two main metabolites in human liver microsomes has been developed. Samples were almost quantitatively isolated by solid phase extraction and further analysed by HPLC. Separation was achieved on an endcapped reversed phase C-18 column with triethylamine as an organic modifier in the mobile phase. The method exhibits high recovery and a good sensitivity for analyses of small sample volumes. The application of the method for screening the metabolism of this new drug in human liver microsomes is presented.

100 项与 PFP-6 (University of Vienna) 相关的药物交易

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