更新于：2024-12-11
Taltirelin Hydrate
他替瑞林水合物
更新于：2024-12-11
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (2000-09-21), |
最高研发阶段(中国)- |
特殊审评孤儿药 (日本) |
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结构
分子式C17H31N7O9 |
InChIKeyHRCJDWMUKPHPHR-NTFWNTCYSA-N |
CAS号201677-75-0 |
关联
4
项与 他替瑞林水合物 相关的临床试验评价他替瑞林片在中国成年健康受试者中的一项单中心、随机、开放、空腹/餐后单次给药、两制剂、两周期、双交叉的生物等效性研究
他替瑞林片随机、开放、两制剂、两周期、双交叉在健康人体餐后条件下生物等效性试验
他替瑞林片随机、开放、两制剂、两周期、双交叉在健康人体空腹条件下生物等效性试验
100 项与 他替瑞林水合物 相关的临床结果
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100 项与 他替瑞林水合物 相关的转化医学
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100 项与 他替瑞林水合物 相关的专利（医药）
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82
项与 他替瑞林水合物 相关的文献（医药）2024-11-27BIOLOGICAL & PHARMACEUTICAL BULLETIN
Thyrotropin-Releasing Hormone Analog Taltirelin Inhibits Acute and Chronic Itch in Mice
Article
作者: Kojima, Fumiaki ; Ogata, Masanori ; Eto, Kei ; Ishibashi, Hitoshi
Itch is an unpleasant sensation that induces a desire to scratch. Chronic itch is accompanied by inflammatory skin diseases and causes repetitive scratching leading to tissue damage. The thyrotropin-releasing hormone analog taltirelin exerts analgesic effects on acute and chronic pain by activating the descending inhibitory systems. However, little is known regarding its effects on acute and chronic itch. In this study, we examined the effects of taltirelin on acute and chronic itch. Subcutaneous injection of chloroquine increased the number of scratching bouts in 30 min, whereas intraperitoneal injection of taltirelin reduced these episodes in a dose-dependent manner. In addition, chronic itch induced by diphenylcyclopropenone treatment was alleviated by taltirelin injection. These findings indicate that taltirelin alleviates acute and chronic itch in mice, and can be a potent therapeutic antipruritic drug.
2024-09-20Cureus Journal of Medical Science
Multiple System Atrophy Masquerading as Drug-Resistant Orthostatic Hypotension
Article
作者: Sasaki, Kenta ; Yamaoka, Manami ; Neshige, Shuichiro ; Maruyama, Hirofumi
A 54-year-old male presented with a two-year history of recurrent syncope. Although he was treated with droxidopa and amezinium metilsulfate, his syncope was drug-resistant. Blood tests, cardiac evaluation and brain computed tomography (CT) were unremarkable. As his Schellong test was positive, orthostatic hypotension and syncope were the tentative diagnoses. Upon evaluating the patient neurologically while carefully avoiding syncope induction, mild cerebellar ataxia was observed. However, a brain magnetic resonance imaging (MRI) scan revealed a possible "cross sign" in the pons. Subsequent dopamine transporter single-photon emission computed tomography (DAT-SPECT) showed reduced uptake in the basal ganglia. Based on these findings, a clinical diagnosis of probable multiple system atrophy of the cerebellar type (MSA-C) was made, and treatment with taltirelin hydrate was initiated. This case underscores the importance of considering multiple system atrophy (MSA) in patients with persistent orthostatic hypotension and syncope, even before more obvious neurodegenerative symptoms emerge.
2024-04-01Nature immunology
A method for predicting drugs that can boost the efficacy of immune checkpoint blockade
Article
作者: Xia, Yun ; Chen, Chuang ; Guo, An-Yuan ; Pan, Wen ; Gan, Lu ; Bie, Nana ; Miao, Ya-Ru ; Gao, Yan ; Liu, Hanqing ; Yang, Mei ; Li, Xin
Combination therapy is a promising therapeutic strategy to enhance the efficacy of immune checkpoint blockade (ICB); however, predicting drugs for effective combination is challenging. Here we developed a general data-driven method called CM-Drug for screening compounds that can boost ICB treatment efficacy based on core and minor gene sets identified between responsive and nonresponsive samples in ICB therapy. The CM-Drug method was validated using melanoma and lung cancer mouse models, with combined therapeutic efficacy demonstrated in eight of nine predicted compounds. Among these compounds, taltirelin had the strongest synergistic effect. Mechanistic analysis and experimental verification demonstrated that taltirelin can stimulate CD8+ T cells and is mediated by the induction of thyroid-stimulating hormone. This study provides an effective and general method for predicting and evaluating drugs for combination therapy and identifies candidate compounds for future ICB combination therapy.
100 项与 他替瑞林水合物 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 脊髓小脑变性 | 日本 | 2009-10-26 | |
| 神经系统疾病 | 日本 | 2000-09-21 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 中枢神经系统疾病 | 临床前 | 日本 | 2002-05-01 |
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