作者: Capuani, Silvia ; Catalano, Carlo ; Manganaro, Lucia ; Camilli, Arianna ; Giancotti, Antonella ; Petrillo, Roberta ; Ricci, Paolo ; Antonelli, Amanda ; Ercolani, Giada ; Satta, Serena ; Ciulla, Sandra ; Grimm, Robert

PURPOSETo investigate the use of IntraVoxel Incoherent Motion (IVIM) MRI in the study of microstructural tissue changes occurring in fetal lung and kidney during gestation.METHODS34 normal pregnancies were enrolled. Patients were divided into two groups based on gestational age (GA): group A (21-29 weeks) and group B (30-39 weeks). MR examinations were performed at 1.5T, with a standard fetal MR protocol including a Diffusion-Weighted Echo-Planar Imaging sequence with 10 different b-values (0, 10, 30, 50, 75, 100, 200, 400, 700, 1000s/mm²). For each fetus, two bilateral ROIs were manually placed in lung and renal parenchyma. Mean values of perfusion fraction f, pseudo-diffusion coefficient D* and diffusion coefficient D were obtained. The correlation between IVIM parameters and GA was investigated.RESULTSIn renal ROIs a positive correlation between f_kidney and GA (p < 0.005) was found; similarly f_lung showed a statistically significant correlation with GA (p < 0.001). F mean values were significantly higher in group B compared to group A in both renal (p = 0.0002) and lung (p = 0.018) ROIs. No correlation was found in D and D* as a function of GA.CONCLUSIONSThe IVIM perfusion fraction f may be considered as a potential marker of pulmonary and renal maturation in relation to hemodynamic changes described in intrauterine life. Our results highlight that IVIM model is useful as an additional prenatal diagnostic tool to study lung and renal development.

2017-11-01·Acta Crystallographica Section A Foundations and Advances3区 · 材料科学

About difference electron densities and their properties

3区 · 材料科学

Article

作者: Cascarano, Giovanni Luca ; Polidori, Giampiero ; Carrozzini, Benedetta ; Burla, Maria Cristina ; Giacovazzo, Carmelo

Difference electron densities do not play a central role in modern phase refinement approaches, essentially because of the explosive success of the EDM (electron-density modification) techniques, mainly based on observed electron-density syntheses. Difference densities however have been recently rediscovered in connection with theVLD(Vive la Difference) approach, because they are a strong support for strengthening EDM approaches and forab initiocrystal structure solution. In this paper the properties of the most documented difference electron densities, here denoted asF−Fp,mF−FpandmF−DFpsyntheses, are studied. In addition, a fourth new difference synthesis, here denoted as {\overline F_q} synthesis, is proposed. It comes from the study of the same joint probability distribution function from which theVLDapproach arose. The properties of the {\overline F_q} syntheses are studied and compared with those of the other three syntheses. The results suggest that the {\overline F_q} difference may be a useful tool for making modern phase refinement procedures more efficient.

2007-05-01·HNO4区 · 医学

Die Behandlung laryngealer Bewegungsstörungen mit Botulinumtoxinen

4区 · 医学

Review

作者: Schwemmle, C ; Ptok, M

Laryngeal dystonia (spasmodic dysphonia) is a movement disorder characterised by involuntary contractions of the laryngeal muscles involved in vocalisation. The introduction of botulinum toxin (BTX) in the treatment of laryngeal dystonia had a major clinical impact due to the striking improvement of symptoms. Most patients with severe types of spasmodic dysphonia are treated with injections of botulinum toxin type A. For patients with a resistance against type A toxin there is a new hypercleaned type A toxin or type B available. Research on type F toxin is also underway. In this article, the history of botulinum toxin, its therapeutic activity and possibilities for its use are described.

100 项与 Recombinant human histone H1.3(SymBio Pharmaceuticals) 相关的药物交易

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适应症	最高研发状态	国家/地区	公司	日期
急性髓性白血病	临床2期	-	Pharmsynthez PJSC	-
急性髓性白血病	临床2期	-	SymBio Pharmaceuticals Ltd.	-
急性髓性白血病	临床2期	-	Xenetic Biosciences, Inc.	-
急性髓性白血病	临床2期	-	Dana-Farber Cancer Institute, Inc.	-
非霍奇金淋巴瘤	临床2期	-	Xenetic Biosciences, Inc.	-
非霍奇金淋巴瘤	临床2期	-	SymBio Pharmaceuticals Ltd.	-
非霍奇金淋巴瘤	临床2期	-	Dana-Farber Cancer Institute, Inc.	-
非霍奇金淋巴瘤	临床2期	-	Pharmsynthez PJSC	-
急性髓性白血病	临床前	俄罗斯	-	-
急性髓性白血病	临床前	德国	-	-

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASCO2009	临床1期	HR阳性/HER2低表达实体瘤	74	FOLFIRI + F	(範遞獵鑰範蓋獵選網餘) = 築壓簾窪餘餘觸繭淵顧選淵觸鏇築網齋選鏇製 (築願築蓋夢構簾廠構繭 )	-	2009-05-20
ASCO2006	N/A	复发性前列腺癌	26	CAB+F	構膚獵糧艱簾構鏇顧積(構醖鬱構窪網衊簾顧鑰) = 鹹鏇獵齋齋簾艱構鏇齋鬱衊淵衊膚獵窪鑰遞構 (衊繭壓糧觸鹹築膚鏇膚 ) 更多	-	2006-06-20
ASCO2006	N/A	复发性前列腺癌	26	ZA	構膚獵糧艱簾構鏇顧積(構醖鬱構窪網衊簾顧鑰) = 壓鏇鹹簾顧膚餘範窪壓鬱衊淵衊膚獵窪鑰遞構 (衊繭壓糧觸鹹築膚鏇膚 ) 更多	-	2006-06-20