Active sampling is a dependable approach for gaseous pollutants monitoring, offering high accuracy and precision that is unaffected by environmental factors such as wind and temperature in comparison to passive sampling. To measure long-term average concentrations while minimizing the use of materials, a reduced sampling rate is necessary. Thus, this study aims to develop a novel low sampling rate (down to 1 mL/min) and cost-efficient active sampler (LASP) for medium/long-term monitoring of gaseous pollutants. The LASP mainly consisted of a syringe pump, a Y-shaped fitting with two one-way valves, and a control unit for intermittent operation. Results showed that LASP can obtain a sampling rate of less than 1 mL/min and sampling rate exhibited a high level of stability. Daily average concentrations measurements for nitrogen dioxide and formaldehyde by LASP had normalized mean biases of 2.8% and 5.2%, respectively. These numbers were - 5.8% and 6.1% for weekly-average samplings. This study demonstrated applications of LASP in real outdoor (daily-average) and indoor (weekly-average) air quality measurements. It worked well with low noise levels, and without interfering with occupants' daily activities. LASP can assist in improving our ability to monitor air quality and pollutants emissions, thereby supporting health research and policy development. ENVIRONMENTAL IMPLICATION: Gaseous air pollution is an important hazardous factor threatening human health. Medium/long-term air quality monitoring is essential for outdoor and indoor air quality assessment and control. However, air sampler for medium/long-term sampling is lacking. This study developed a novel low sampling rate and cost-efficient active sampler and applied it to medium/long-term air sampling. The sampler can work at a sampling rate of less than 1 mL/min. This technology provides a feasible strategy for medium/long-term monitoring of gaseous air pollutants in both environments and emission hotspots.

2023-10-01·Pest management science

Virulence of the fungal pathogen, Aspergillus oryzae XJ-1 to adult locusts (Orthoptera: Acrididae) in both laboratory and field trials.

Article

作者: An, Zhifei ; Zhang, Long ; Yang, Wen ; Wang, Tongwei ; Zhang, Xingchen ; Xie, Xiuhua ; Yang, Mingquan ; Liu, Hui ; You, Yinwei

BACKGROUNDLocusts and grasshoppers are pests of many agricultural crops, and their frequent outbreaks worldwide threaten food security. Microbial control agents are currently used to suppress the early (nymphal) stages of pests, but they are often less effective against adults, which are primarily responsible for locust plagues. The fungal pathogen Aspergillus oryzae XJ-1 has high pathogenicity in locust nymphs. To assess its potential for controlling locust adults, we evaluated the virulence of A. oryzae XJ-1 (i.e., locust Aspergillus, LAsp) in locust adults using laboratory, field-cage experiments, and a field trial.RESULTSThe lethal concentration of LAsp in adult Locusta migratoria was 3.58 ± 0.09 × 10⁵ conidia mL^-1 15 days after inoculation in the laboratory. A field-cage experiment showed that the mortalities of adult L. migratoria were 92.0 ± 4.6% and 90.1 ± 3.2% 15 days after inoculation with 3 × 10⁵ and 3 × 10³ conidia m^-2 of LAsp, respectively. A large-scale field trial of 666.6 ha was conducted, in which a LAsp water suspension was applied at a concentration of 2 × 10⁸ conidia mL^-1 in 15 L ha^-1 by aerial spraying via drones. The densities of mixed populations of L. migratoria and Epacromius spp. were significantly reduced by 85.4 ± 7.9%-94.9 ± 5.1%. In addition, the infection rates of surviving locusts collected from the treated plots were 79.6% and 78.3% on the 17th and 31st day after treatment, respectively.CONCLUSIONThese results indicate that A. oryzae XJ-1 is highly virulent in adult locusts and that it has high potential for the control of locusts. © 2023 Society of Chemical Industry.

2023-09-01·International journal of hematology

L-asparaginase as an efficient salvage therapy for refractory acute myeloid leukemia with chromosome 7 abnormalities: a case series.

Article

作者: Kuroda, Rie ; Takenaka, Mika ; Noguchi, Kazuhiro ; Maeba, Hideaki ; Wada, Taizo ; Fujiki, Toshihiro ; Goto, Hiroaki ; Sakai, Yuta ; Ikawa, Yasuhiro ; Kitoh, Toshiyuki

Acute myeloid leukemia (AML) with chromosome 7 abnormalities has a dismal prognosis due to a poor complete remission (CR) rate after induction chemotherapy. Although various salvage therapies for refractory AML have been developed for adults, few salvage therapies are available for children. Here, we report the cases of three patients with refractory AML with chromosome 7 abnormalities (Patient 1, with inv(3)(q21;3q26.2) and monosomy 7; Patient 2, with der(7)t(1;7)(?;q22); patient 3, with monosomy 7) who were successfully treated with L-asparaginase (L-ASP) as salvage therapy. All three patients achieved CR several weeks after L-ASP treatment, and two patients successfully underwent hematopoietic stem cell transplantation (HSCT). Patient 2 relapsed after the second HSCT in the form of an intracranial lesion, but achieved and sustained CR for 3 years with weekly L-ASP maintenance therapy. Immunohistochemical staining for asparagine synthetase (ASNS), whose gene is located at 7q21.3, was performed for each patient. The result was negative in all patients, which suggests that haploid 7q21.3 and other chromosome 7 abnormalities leading to haploinsufficiency of ASNS contribute to a high susceptibility to L-ASP. In conclusion, L-ASP is a promising salvage therapy for refractory AML with chromosome 7 abnormalities, which are associated with ASNS haploinsufficiency.

100 项与 LASP(Antlia Bioscience) 相关的药物交易

登录后查看更多信息