作者: Sierra, Gustavo ; Valdés, Yolanda ; González, Marta ; Suárez, Miguel ; Naranjo, Mariela ; Amador, Nelly ; Fernández, Carmen ; Infante, Juan F ; Batista, Niurka ; González, Irma

Honduras was one of the Central American countries most severely hit by Hurricane Mitch. Torrential rains and heavy flooding created conditions conducive to a leptospirosis outbreak in the country. A group of Cuban scientists studied 68 patients from the Department of Cort�s - one of the country's hardest hit areas - presenting clinical and epidemiological profiles indicative of leptospirosis. Blood and serum samples were taken from all subjects. A microscopic agglutination test (MAT) was used to identify Leptospira strains and to assess protection conferred by vax-SPIRAL® (Cuban leptospirosis vaccine) against the isolated strain. Prevalence of leptospires in the kidneys and liver was also verified. A male predominance was found in the group aged 15-49 years. Municipalities in this Department with the largest number of cases were San Pedro Sula, La Lima, and Chamelec�n. The most frequent symptoms included fever, headache, myalgia, and generalized discomfort. Over 80% of subjects reported presence of rodents in their homes, as well as contact with stagnant water and domestic animals. The strain isolated from positive blood cultures was from the Icterohaemorrhagiae serogroup, which was highly virulent in the animal model used. Protection was 100% in hamsters inoculated with vax-SPIRAL® and subsequently challenged with the Honduran strain. Additionally, macroscopic analysis of organs from immunized animals that survived the challenge showed no signs of leptospirosis infection.

Revista cubana de medicina tropical

[Serological response by ELISA and MAT in Cuban volunteers vaccinated with vax SPIRAL].

Article

作者: Rodríguez, José ; Rodríguez, Islay ; Martínez, Gerardo ; Obregón, Ana Margarita ; Llop, Alina ; Fernández, Carmen ; Martínez, Raydel

The seroconversion of 408 vaccinated individuals and 135 placebo included in 2 clinical trials of the Cuban vaccine against human leptospirosis was studied. 2 vaccine doses and 5 schemes were studied. Of 38 vaccinated subjects (Phase I), 11 (29 %) seroconverted by MAT and 12 (32 %) by ELISA, whereas in 33 placebo, seroconversion was observed in 2 (6 %) and 3 (9 %), respectively. In Phase II, of 68 vaccinated individuals (doses of 0.25 mL) and of 65 (doses of 0.50 mL), seroconversion was attained in 21 (31 %) and 16 (25 %) by ELISA, respectively, 9 by MAT (13 %) and 7 (11 %) were positive. There were no significant differences between the doses used. The seroconversion by MAT in 237 subjects vaccinated with different schemes was 22.4 %. No marked differences were observed between them. In most of the reactive individuals, antibody levels were found in at least one of the vaccine strains. It was recommended to search and evaluate other methods to show in vivo the level of protection of this vaccine.

Revista cubana de medicina tropical

Escalado de la fermentación de Leptospira interrogans canicola canicola para la producción de la vacuna vax-SPIRAL.

Article

作者: Hernández, Damián Rojo ; Torres, Florinda Hernández ; Enrique, Kenia Fernández ; Airado, Janet Lazo ; Boué, Raúl Gutiérrez ; Zamora, José Daniel Benítez

The operational conditions for the production of vaccine vax-SPIRAL were established at the scale of 100 L. It was concluded that it should be carried out with an air flow of 10 L/min (0.1 vvm) and without mechanical agitation.

100 项与 Leptospirosis vaccine trivalent (Finlay Institute) 相关的药物交易

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KEGG	Wiki	ATC	Drug Bank
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钩端螺旋体病	古巴	-	1998-01-01

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适应症	最高研发状态	国家/地区	公司	日期
钩端螺旋体病	临床2期	巴西	Abivax SA	2014-11-12
钩端螺旋体病	临床2期	印尼	Abivax SA	2014-11-12
钩端螺旋体病	临床2期	印度	Abivax SA	2014-11-12
钩端螺旋体病	临床2期	菲律宾	Abivax SA	2014-11-12
钩端螺旋体病	临床2期	墨西哥	Abivax SA	2014-11-12
钩端螺旋体病	临床2期	乌拉圭	Abivax SA	2014-11-12