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更新于：2025-05-07

Thyroglobulin

更新于：2025-05-07

概要

概要

基本信息

药物类型

蛋白类药物

别名

Thyroglobulin

靶点-

作用方式-

作用机制-

治疗领域-

在研适应症-

非在研适应症-

原研机构

Impax Laboratories LLC

在研机构-

非在研机构

Impax Laboratories LLC

权益机构-

最高研发阶段撤市

首次获批日期

美国 (2001-08-16)

最高研发阶段(中国)-

特殊审评-

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结构/序列

Sequence Code 33559217

来源: *****

关联

100 项与 Thyroglobulin 相关的临床结果

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100 项与 Thyroglobulin 相关的转化医学

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100 项与 Thyroglobulin 相关的专利（医药）

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项与 Thyroglobulin 相关的文献（医药）

2024-12-24·Cureus

Granulomatous Tubulointerstitial Nephritis as a Rare Cause of Allograft Failure: A Case Report

Article

作者: Roche-Recinos, Andrea ; Nnaji, Okwudili ; Yeboah, Eugene K ; Yang, Yihe ; Saggi, Subodh

Although granulomatous interstitial nephritis (GIN) is a rare histological finding in kidney transplants, the joint occurrence of GIN and focal segmental glomerulosclerosis (FSGS) has not, to our knowledge, been reported in the literature. We report a case of GIN and de novo FSGS in kidney transplant recipients leading to allograft failure. A 69-year-old male with a history of end-stage renal disease (ESRD) of unknown etiology, as well as liver failure from hepatitis B and C co-infection, initially had a living unrelated kidney transplant (LURT) in 2007 and subsequently received both liver and kidney transplants (SLKTs) in 2017. His second post-transplant course in 2017 was complicated by antibody-mediated rejection, recurrent urinary tract infections, and an episode of cell-mediated rejection, which was treated with both corticosteroids and thyroglobulin. In 2023, his serum creatinine remained stable, ranging from 2.2 to 2.9 mg/dL, with maintenance immunosuppression of mycophenolate mofetil (750 mg twice a day), tacrolimus (4 mg twice a day; target of 5-7 ng/mL), and prednisone (5 mg daily). In February 2024, his serum creatinine increased to 4.3 mg/dL, with nephrotic-range proteinuria (urine protein-to-creatinine ratio of 6000 mg/g) and urinalysis showing pyuria (white blood cell count of 49), but no hematuria. All infectious work-ups, including urine culture, blood culture, QuantiFERON-TB Gold, and sputum Mycobacterium tuberculosis polymerase chain reaction (MTB-PCR) (×3), were negative. An allograft biopsy showed acute granulomatous tubulo-interstitial nephritis, along with de novo collapsing FSGS and recurrent diabetic nephropathy. There was no evidence of active T-cell-mediated, vascular, or antibody-mediated rejection (negative C4d). The kidney biopsy for in-tissue MTB-PCR testing was negative. To the best of our knowledge, our patient is the first case of idiopathic GIN with non-necrotizing granulomata, along with de novo collapsing FSGS, leading to allograft failure.

2024-10-22·Journal of Endocrinology

Thyroglobulin and calcitonin measurements: pitfalls and future perspectives

Review

作者: Hillebrand, Jacquelien J ; Heijboer, Annemieke C ; Boelen, Anita ; Mater, Amber

Thyroid cancer is the most prevalent endocrine cancer, and the prognosis depends on the type and stage of cancer at the time of discovery. The treatment involves (hemi-)thyroidectomy, possibly followed by additional therapeutic options. After treatment, patients are monitored using serum concentrations of endocrine tumour markers: thyroglobulin (Tg) in case of differentiated cancer and calcitonin in case of medullary thyroid cancer. Measuring Tg and calcitonin concentrations in serum may be challenging. In this review, we provide a complete overview of the evolution in laboratory measurements of Tg and calcitonin, with an emphasis on (pre-)analytical challenges and potential approaches to overcome current pitfalls.

2023-10-09·Journal of the Endocrine Society

Exploring the Association Between Thyroid Function and Oral Microbiome Diversity: An NHANES Analysis

Article

作者: Zhang, Jing ; Lin, Bo ; Lv, Weiming ; Luo, Jiajun ; Yang, Rui ; Li, Ruixia ; Chen, Wanna ; Zheng, Liang

AbstractObjectiveTo investigate the association between thyroid functions and the oral microbiome diversity.MethodData from the US National Health and Nutrition Examination Survey (NHANES; 2009-2012) were analyzed. Thyroid functions were defined using thyroid hormones and related biomarkers. Oral microbiome was measured using the observed number of amplicon sequence variants (ASVs) and the Bray-Curtis dissimilarity. Linear regression was used to estimate the average change (β) and 95% CI for the number of ASVs against thyroid functions, adjusted for sociodemographic variables, health conditions, urinary iodine status, and periodontitis. Non-metric multidimensional scaling (NMDS) was used to analyze the Bray-Curtis dissimilarity.ResultsA total of 2943 participants were analyzed. The observed number of ASVs has a weighted mean of 128.9. Self-reported thyroid disease was associated with reduced number of ASVs (β = −9.2, 95% CI: −17.2, −1.2), if only adjusted for sociodemographic variables and health conditions. In the fully adjusted model, compared to normal thyroid function, both subclinical and clinical hyperthyroidism were associated with reduced number of ASVs (β = −59.6, 95% CI: −73.2, −46.0; β = −28.2, 95% CI: −50.0, −6.5, respectively). Thyroid peroxidase antibody level higher than the reference range was associated with higher observed ASV (β= 9.0, 95% CI: 1.2, 16.9). NMDS analysis suggested significant difference in oral microbiome composition between free triiodothyronine groups (P = .002), between free thyroxine groups (P = .015), and between thyroglobulin groups (P = .035).ConclusionHyperthyroidism was associated with reduced oral microbiome diversity. Free triiodothyronine, free thyroxine, and thyroglobulin levels may alter the oral microbiome composition.

100 项与 Thyroglobulin 相关的药物交易

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