更新于：2024-11-04
Desonide
地奈德
更新于：2024-11-04
概要
基本信息
药物类型 小分子化药 |
别名 11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione、11β,21-dihydroxy-16α,17-isopropylidenedioxypregna-1,4-diene-3,20-dione、11β,21-dihydroxy-16α,17α-isopropylidenedioxypregna-1,4-diene-3,20-dione + [14] |
靶点 |
作用机制 GR激动剂(糖皮质激素受体激动剂) |
非在研适应症- |
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1972-01-04), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C24H32O6 |
InChIKeyWBGKWQHBNHJJPZ-LECWWXJVSA-N |
CAS号638-94-8 |
关联
31
项与 地奈德 相关的临床试验地奈德洗剂生物等效性研究与人体药代动力学对比研究
地奈德乳膏人体药代动力学对比研究
地奈德乳膏人体生物等效性研究
100 项与 地奈德 相关的临床结果
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100 项与 地奈德 相关的转化医学
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100 项与 地奈德 相关的专利（医药）
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219
项与 地奈德 相关的文献（医药）2024-12-31JOURNAL OF DERMATOLOGICAL TREATMENT
A pediatric case of dupilumab-induced pustular psoriasis
Article
作者: Zheng, Huiwen ; Dang, Nan ; Ren, Yunqing
Dupilumab is a novel treatment agent for moderate to severe atopic dermatitis (AD) with few adverse effects. Drug-induced psoriasiform lesions are rare.We report a 4-year-old boy with AD who developed pustular psoriasis during treatment with dupilumab.Pustular psoriasis appeared within 1 week of treatment and worsened in the second week. After stopping dupilumab administration, topical corticosteroids (desonide and mometasone furoate creams) and oral desloratadine without relief. Pustular psoriasis was confirmed by pathological examination, and thiamphenicol was administered. After 2 weeks of treatment, the lesions nearly resolved without recurrence in 1-year follow-up.Dupilumab-induced pustular psoriasis is rare in children.
2024-10-01Ophthalmology and Therapy
Correction: Observational Clinical Investigation Evaluating an Ophthalmic Solution Containing Xanthan Gum and Low Concentration Desonide Phosphate in Dry Eye Disease Treatment
作者: Genovese, Paola ; Gagliano, Caterina ; Dammino, Edoardo ; Postorino, Elisa Imelde ; D’Esposito, Fabiana ; Giannaccare, Giuseppe ; D'Esposito, Fabiana ; Aragona, Pasquale ; Mazzone, Maria Grazia ; Civiale, Claudine
2024-10-01Ophthalmology and Therapy
Observational Clinical Investigation Evaluating an Ophthalmic Solution Containing Xanthan Gum and Low Concentration Desonide Phosphate in Dry Eye Disease Treatment
Article
作者: Genovese, Paola ; Gagliano, Caterina ; Dammino, Edoardo ; Postorino, Elisa Imelde ; Giannaccare, Giuseppe ; Aragona, Pasquale ; Mazzone, Maria Grazia ; D'Esposito, Fabiana ; Civiale, Claudine
INTRODUCTION:
Patients with dry eye disease (DED) complain of a multitude of symptoms that affect their visual function and quality of life (QoL). This clinical investigation assessed the performance, tolerance, and safety of a novel preservative-free ophthalmic solution containing xanthan gum 0.2% and desonide sodium phosphate 0.025%.
METHODS:
This was an observational, prospective, multicentric, and post-market clinical investigation to assess the effect of three times a day instillation of the study formulation in patients suffering from DED. The primary objective was to achieve a 50% reduction in conjunctival hyperemia index as assessed with the OCULUS Keratograph after 1 month of treatment compared to baseline values. The secondary objectives included patient-reported outcomes, clinical performance, and safety.
RESULTS:
Thirty patients were enrolled (21 women, 9 men) with a mean age of 61.10 ± 14.53 years. The instillation of the study formulation was associated with a significant reduction in redness scores after 1 month of treatment compared to baseline (mean - 0.51 ± 0.51; p ≤ 0.0001). Although the primary endpoint was not completely met, a 50% reduction in the conjunctival hyperemia index was achieved in 23% of the participants, and 77% showed a reduction of 26% of the same index. In addition, the ophthalmic solution significantly increased tear film break-up time, and a significant reduction of corneal and conjunctival staining with fluorescein was achieved. It also reduced DED symptoms and had a very good safety profile.
CONCLUSIONS:
the study formulation produced a significant improvement in the signs, symptoms, and QoL of patients with mild to moderate DED with a good safety profile after 1 month of treatment.
100 项与 地奈德 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 皮炎 | 中国 | 1995-01-01 | |
| 特应性皮炎 | 美国 | 1974-11-01 | |
| 瘙痒 | 美国 | 1972-01-04 |
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