TH-001(Taihe)(TH-001(Taihe)) - 在研适应症：实体瘤_专利_临床

概要

基本信息

药物类型

纳米抗体

别名

靶点-

作用方式-

作用机制-

治疗领域

肿瘤

在研适应症

实体瘤

非在研适应症-

原研机构

济南泰和医药科技有限公司

在研机构

济南泰和医药科技有限公司

非在研机构-

权益机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)临床前

特殊审评-

关联

100 项与 TH-001(Taihe) 相关的临床结果

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100 项与 TH-001(Taihe) 相关的转化医学

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100 项与 TH-001(Taihe) 相关的专利（医药）

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1

项与 TH-001(Taihe) 相关的文献（医药）

1982-09-01·Gan to kagaku ryoho. Cancer & chemotherapy

[Characterization and bioactivity of interferon induced by Streptococcus faecalis preparation, TH69].

Article

作者: Saito, M ; Kawade, Y ; Kuroda, Y ; Ebina, T ; Ishida, N ; Hoshino, F ; Yamaguchi, T

It was demonstrated that TH69, an lyophylized preparation of streptococcus faecalis TH001 (ATCC No. 31663) induced interferon gamma (IFN gamma) in spleen cell cultures. The IFN activity was found in 8 hrs and reached to the peak of 120-240 U/ml 24-48 hrs after incubation in every concentration of 4, 20, and 100 micrograms/ml of TH69. TH69-induced IFN (TH69-IFN) was produced by T cells assisted by macrophages which were stimulated with TH69, and the activity was neutralized by 80-90% with anti-IFN gamma serum but hardly neutralized with anti-IFN alpha, beta serum. Therefore, TH69-IFN was found to be mostly gamma type. The elution profile of TH69-IFN activity on a column with Toyopearl HW-55S showed that molecular weight of IFN was estimated at 18,000-28,000. Sequential purification on this column of TH69-IFN increased the specific activity to approximately 2.5 X 10(4) U/mg protein (partially purified TH69-IFN: TH69-IFNp). A small amount of TH69-IFNp (5-50 U/ml) augmented NK activity and induced cytotoxic macrophages in vitro. Growth of Meth-A tumor cells exposed to TH69-IFNp of 100 U/ml in vitro declined to 50% and three times injection of TH69-IFN (200 U/50 microliters) into the tumor sites of mice given implants of Meth-A suppressed the tumor growth.

100 项与 TH-001(Taihe) 相关的药物交易

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