Effect of Lactase Enzyme chewable tablets on Hydrogen Breath Excretion and Intestinal Symptoms in patients of Lactose Malabsorption and Intolerance: A Crossover double-blind placebo-controlled study

开始日期2018-02-25

申办/合作机构-

CTRI/2017/12/010930 / CompletedN/A

Efficacy and Safety of Lactase in Infantile Colic: A Randomized Placebo Controlled Trial

开始日期2018-01-01

申办/合作机构-

100 项与半乳糖苷酶(Recordati SpA) 相关的临床结果

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100 项与半乳糖苷酶(Recordati SpA) 相关的转化医学

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100 项与半乳糖苷酶(Recordati SpA) 相关的专利（医药）

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366

项与半乳糖苷酶(Recordati SpA) 相关的文献（医药）

2024-10-01·JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Lactase for infantile colic: A systematic review of randomized clinical trials

Review

作者: Deboni, Mariana ; de Carlos, Gabriel Assis ; Cezar, Alessandra Bacelar ; Bassan, Amanda Santiago ; Nau, Angélica Luciana

Abstract:

Infantile colic is excessive crying for no apparent reason in an otherwise healthy infant. Although its physiopathology is not completely understood, therapies usually target gastrointestinal symptoms. This systematic review of randomized controlled trials (RCTs) analyzes the efficacy of lactase supplementation in infantile colic. PubMed, Embase, and Cochrane were searched for RCTs evaluating lactase supplementation in infants up to 6 months old with infantile colic. Out of six RCTs including 394 patients, three reported a significantly shorter crying time in the lactase group than in the placebo group, while the other three found no significant difference between groups. Of the two studies that performed the hydrogen breath test, only one reported a significant reduction in exhaled hydrogen levels. The pharmacological approach to infantile colic remains debatable, and new studies with standardized diagnostic criteria and outcomes are required to guide lactase supplementation in clinical practice.

2024-09-01·FOOD AND CHEMICAL TOXICOLOGY

Comparison of the developmental effects of lactase or bisphenol A antibody immobilized polycaprolactone/silk fibroin nanofibers on zebrafish embryos

Article

作者: Emekli-Alturfan, Ebru ; Tunalı Akbay, Tuğba ; Ünal, İsmail ; Sivas, Güzin Göksun ; Gürel-Gökmen, Begüm

This study aimed to detect the biocompatibility of bioactivated polycaprolactone/silk fibroin-based nanofibers in vivo using zebrafish embryos. Anti-Bisphenol A (BPA) antibody or lactase enzyme was immobilized on electrospun nanofibers, for making the nanofiber bioactive. Lactase immobilized nanofiber was developed to hydrolyze lactose and produce milk with reduced lactose. Anti-BPA antibody immobilized nanofiber was developed to remove bisphenol A from liquids. To test the biocompatibility of the bioactive nanofibers, the zebrafish embryos were divided into 4 groups; control, raw nanofiber, lactase immobilized nanofiber, and anti-BPAantibody immobilized nanofiber groups. In nanofiber-based exposure groups; nanofibers were incubated separately in the embryonic development medium. Subsequently, the embryos were kept in these development mediums for 72 h post-fertilization (72 hpf) and their developmental analyzes were performed. At the end of 72 hpf, zebrafish embryos were homogenized. Lipid peroxidation and nitrite oxide levels, and superoxide dismutase and glutathione-S-transferase activities were determined to monitor the disturbance of oxidant-antioxidant balance in zebrafish embryos. Exposure to bioactive nanofibers slightly disrupted the oxidant-antioxidant balance, but this change did not affect the mortality and hatching times of the embryos. In conclusion, zebrafish embryos have been effectively used in biocompatibility testing for bioactive nanofibers suggesting that these materials are biocompatible.

2024-06-01·MYCOPATHOLOGIA

Exploring European Consensus About the Remaining Treatment Challenges and Subsequent Opportunities to Improve the Management of Invasive Fungal Infection (IFI) in the Intensive Care Unit

Article

作者: Wyncoll, Duncan ; Wichmann, Dominic ; Enoch, David A ; Hoenigl, Martin ; Cortegiani, Andrea

Abstract:

Background:

The global prevalence of invasive fungal infections (IFI) is increasing, particularly within Intensive Care Units (ICU), where Candida spp. and Aspergillus spp. represent the most important pathogens. Diagnosis and management of IFIs becomes progressively challenging, with increasing antifungal resistance and the emergence of rare fungal species.Through a consensus survey focused on assessing current views on how IFI should be managed, the aim of this project was to identify challenges around diagnosing and managing IFIs in the ICU. The current status in different countries and perceived challenges to date amongst a multidisciplinary cohort of healthcare professionals involved in the care of IFI in the ICU was assessed.

Methods:

Using a modified Delphi approach, an expert panel developed 44 Likert-scale statements across 6 key domains concerning patient screening and minimal standards for diagnosis of IFIs in ICU; initiation and termination of antifungal treatments and how to minimise their side effects and insights for future research on this topic. These were used to develop an online survey which was distributed on a convenience sampling basis utilising the subscriber list held by an independent provider (M3 Global). This survey was distributed to intensivists, infectious disease specialists, microbiologists and antimicrobial/ICU pharmacists within the UK, Germany, Spain, France and Italy. The threshold for consensus was set at 75%.

Results:

A total of 335 responses were received during the five-month collection period. From these, 29/44 (66%) statements attained very high agreement (90%), 11/44 (25%) high agreement (< 90% and ≥ 75%), and 4/44 (9%) did not meet threshold for consensus (< 75%).

Conclusion:

The results outline the need for physicians to be aware of the local incidence of IFI and the associated rate of azole resistance in their ICUs. Where high clinical suspicion exists, treatment should start immediately and prior to receiving the results from any diagnostic test. Beta-D-glucan testing should be available to all ICU centres, with results available within 48 h to inform the cessation of empirical antifungal therapy. These consensus statements and proposed measures may guide future areas for further research to optimise the management of IFIs in the ICU.

项与半乳糖苷酶(Recordati SpA) 相关的新闻（医药）

2022-11-02

·PRNewswire

Malabsorption Syndrome Market Size to Grow by USD 1.55 Bn, Lactose Intolerance to be Largest Revenue-generating Disease Type Segment - Technavio

NEW YORK, Nov. 2, 2022 /PRNewswire/ -- The malabsorption syndrome market size is set to grow by USD 1.55 billion from 2021 to 2026. In addition, the growth momentum of the market will accelerate at a CAGR of 7.73% during the forecast period, according to Technavio. The higher consumption of gluten-containing food is driving the malabsorption syndrome market growth. However, factors such as shifting preferences toward dairy-free alternatives may challenge the market growth. Continue Reading Technavio has announced its latest market research report titled Global Malabsorption Syndrome Market 2022-2026 The report offers an up-to-date analysis regarding the current market scenario, the latest trends and drivers, and the overall market environment. Read FREE Sample Report Malabsorption Syndrome Market 2022-2026: Segmentation Disease type Lactose intolerance: The lactose intolerance segment will be a significant contributor to market growth during the forecast period. Pharma lactase is a lactase enzyme that is produced by the fermentation of a selected strain of bacteria that hydrolyze lactose. Lactase is available as an over-the-counter prevention drug for lactose intolerance. Diagnostic tests such as lactose intolerance test and hydrogen breath test are used to determine the presence of lactose malabsorption, which is also known as maldigestion. The rising application of such tests is expected to drive the growth of the lactose intolerance segment during the forecast period. Sprue Cystic fibrosis Geography North America: North America will account for 38% of the market's growth during the forecast period. This growth is attributed to factors such as the high consumption of gluten-containing foods and the growing prevalence of celiac diseases. However, market growth in this region will be slower than the growth of the market in Europe and Asia. The US and Canada are the key countries for the malabsorption syndrome market in North America. Europe Asia Rest Of World (ROW) Learn about the contribution of each segment summarized in concise infographics and thorough descriptions. Request a FREE PDF Sample Now Malabsorption Syndrome Market 2022-2026: Vendor Analysis and Scope To help businesses improve their market position, Technavio's report provides a detailed analysis of around 25 vendors operating in the market. Some of the major vendors of the malabsorption syndrome market include AbbVie Inc., Ache Laboratorios Farmaceuticos SA, Aspen Pharmacare Holdings Ltd., Bausch Health Companies Inc., Baxter International Inc., COSMO PHARMACEUTICALS NV, Ferring B.V., Koninklijke DSM NV, Lannett Co. Inc., Merck and Co. Inc., Novartis AG, Organon and Co., Perrigo Co. Plc, ProThera Biologics Inc., Sanofi, Tillotts Pharma AG, Xspire Pharma LLC, and Pfizer Inc. The report also covers the following areas : Malabsorption Syndrome Market size Malabsorption Syndrome Market trends Malabsorption Syndrome Market industry analysis This report provides a full list of key vendors, their strategies, and latest developments. Buy Now for detailed vendor information Malabsorption Syndrome Market 2022-2026: Key Highlights CAGR of the market during the forecast period 2022-2026 Detailed information on factors that will assist malabsorption syndrome market growth during the next five years Estimation of the malabsorption syndrome market size and its contribution to the parent market Predictions on upcoming trends and changes in consumer behavior The growth of the malabsorption syndrome market Analysis of the market's competitive landscape and detailed information on vendors Comprehensive details of factors that will challenge the growth of malabsorption syndrome market vendors Get lifetime access to our Technavio Insights. Subscribe now to our most popular "Basic Plan" billed annually at USD 5000. View 100 reports and download 5 reports monthly! Related Reports Lennox-Gastaut Syndrome Treatment Market by Type and Geography - Forecast and Analysis 2022-2026: The introduction of phytochemicals is a key trend. The currently available chemical molecule-based therapies and surgical treatments for LGS are not fully effective in all cases. Phytochemicals are biologically active compounds that are produced from plants. Chronic Fatigue Syndrome Therapeutics Market by Product and Geography - Forecast and Analysis 2022-2026: The development of new diagnostic tests for CFS is a key trend. Currently, there is no standard and reliable diagnostic test for the diagnosis of CFS. Recently, researchers at the Stanford University School of Medicine identified a biomarker and developed a blood test for the diagnosis of CFS. Browse Health Care Market Reports Table of Contents 1 Executive Summary 1.1 Market overview Exhibit 01: Executive Summary – Chart on Market Overview Exhibit 02: Executive Summary – Data Table on Market Overview Exhibit 03: Executive Summary – Chart on Global Market Characteristics Exhibit 04: Executive Summary – Chart on Market by Geography Exhibit 05: Executive Summary – Chart on Market Segmentation by Disease Type Exhibit 06: Executive Summary – Chart on Incremental Growth Exhibit 07: Executive Summary – Data Table on Incremental Growth Exhibit 08: Executive Summary – Chart on Vendor Market Positioning 2 Market Landscape 2.1 Market ecosystem Exhibit 09: Parent market Exhibit 10: Market Characteristics 3 Market Sizing 3.1 Market definition Exhibit 11: Offerings of vendors included in the market definition 3.2 Market segment analysis Exhibit 12: Market segments 3.3 Market size 2021 3.4 Market outlook: Forecast for 2021-2026 Exhibit 13: Chart on Global - Market size and forecast 2021-2026 ($ million) Exhibit 14: Data Table on Global - Market size and forecast 2021-2026 ($ million) Exhibit 15: Chart on Global Market: Year-over-year growth 2021-2026 (%) Exhibit 16: Data Table on Global Market: Year-over-year growth 2021-2026 (%) 4 Five Forces Analysis 4.1 Five forces summary Exhibit 17: Five forces analysis - Comparison between 2021 and 2026 4.2 Bargaining power of buyers Exhibit 18: Chart on Bargaining power of buyers – Impact of key factors 2021 and 2026 4.3 Bargaining power of suppliers Exhibit 19: Bargaining power of suppliers – Impact of key factors in 2021 and 2026 4.4 Threat of new entrants Exhibit 20: Threat of new entrants – Impact of key factors in 2021 and 2026 4.5 Threat of substitutes Exhibit 21: Threat of substitutes – Impact of key factors in 2021 and 2026 4.6 Threat of rivalry Exhibit 22: Threat of rivalry – Impact of key factors in 2021 and 2026 4.7 Market condition Exhibit 23: Chart on Market condition - Five forces 2021 and 2026 5 Market Segmentation by Disease Type 5.1 Market segments Exhibit 24: Chart on Disease Type - Market share 2021-2026 (%) Exhibit 25: Data Table on Disease Type - Market share 2021-2026 (%) 5.2 Comparison by Disease Type Exhibit 26: Chart on Comparison by Disease Type Exhibit 27: Data Table on Comparison by Disease Type 5.3 Lactose intolerance - Market size and forecast 2021-2026 Exhibit 28: Chart on Lactose intolerance - Market size and forecast 2021-2026 ($ million) Exhibit 29: Data Table on Lactose intolerance - Market size and forecast 2021-2026 ($ million) Exhibit 30: Chart on Lactose intolerance - Year-over-year growth 2021-2026 (%) Exhibit 31: Data Table on Lactose intolerance - Year-over-year growth 2021-2026 (%) 5.4 Sprue - Market size and forecast 2021-2026 Exhibit 32: Chart on Sprue - Market size and forecast 2021-2026 ($ million) Exhibit 33: Data Table on Sprue - Market size and forecast 2021-2026 ($ million) Exhibit 34: Chart on Sprue - Year-over-year growth 2021-2026 (%) Exhibit 35: Data Table on Sprue - Year-over-year growth 2021-2026 (%) 5.5 Cystic fibrosis - Market size and forecast 2021-2026 Exhibit 36: Chart on Cystic fibrosis - Market size and forecast 2021-2026 ($ million) Exhibit 37: Data Table on Cystic fibrosis - Market size and forecast 2021-2026 ($ million) Exhibit 38: Chart on Cystic fibrosis - Year-over-year growth 2021-2026 (%) Exhibit 39: Data Table on Cystic fibrosis - Year-over-year growth 2021-2026 (%) 5.6 Market opportunity by Disease Type Exhibit 40: Market opportunity by Disease Type ($ million) 6 Customer Landscape 6.1 Customer landscape overview Exhibit 41: Analysis of price sensitivity, lifecycle, customer purchase basket, adoption rates, and purchase criteria 7 Geographic Landscape 7.1 Geographic segmentation Exhibit 42: Chart on Market share by geography 2021-2026 (%) Exhibit 43: Data Table on Market share by geography 2021-2026 (%) 7.2 Geographic comparison Exhibit 44: Chart on Geographic comparison Exhibit 45: Data Table on Geographic comparison 7.3 North America - Market size and forecast 2021-2026 Exhibit 46: Chart on North America - Market size and forecast 2021-2026 ($ million) Exhibit 47: Data Table on North America - Market size and forecast 2021-2026 ($ million) Exhibit 48: Chart on North America - Year-over-year growth 2021-2026 (%) Exhibit 49: Data Table on North America - Year-over-year growth 2021-2026 (%) 7.4 Europe - Market size and forecast 2021-2026 Exhibit 50: Chart on Europe - Market size and forecast 2021-2026 ($ million) Exhibit 51: Data Table on Europe - Market size and forecast 2021-2026 ($ million) Exhibit 52: Chart on Europe - Year-over-year growth 2021-2026 (%) Exhibit 53: Data Table on Europe - Year-over-year growth 2021-2026 (%) 7.5 Asia - Market size and forecast 2021-2026 Exhibit 54: Chart on Asia - Market size and forecast 2021-2026 ($ million) Exhibit 55: Data Table on Asia - Market size and forecast 2021-2026 ($ million) Exhibit 56: Chart on Asia - Year-over-year growth 2021-2026 (%) Exhibit 57: Data Table on Asia - Year-over-year growth 2021-2026 (%) 7.6 Rest of World (ROW) - Market size and forecast 2021-2026 Exhibit 58: Chart on Rest of World (ROW) - Market size and forecast 2021-2026 ($ million) Exhibit 59: Data Table on Rest of World (ROW) - Market size and forecast 2021-2026 ($ million) Exhibit 60: Chart on Rest of World (ROW) - Year-over-year growth 2021-2026 (%) Exhibit 61: Data Table on Rest of World (ROW) - Year-over-year growth 2021-2026 (%) 7.7 US - Market size and forecast 2021-2026 Exhibit 62: Chart on US - Market size and forecast 2021-2026 ($ million) Exhibit 63: Data Table on US - Market size and forecast 2021-2026 ($ million) Exhibit 64: Chart on US - Year-over-year growth 2021-2026 (%) Exhibit 65: Data Table on US - Year-over-year growth 2021-2026 (%) 7.8 Germany - Market size and forecast 2021-2026 Exhibit 66: Chart on Germany - Market size and forecast 2021-2026 ($ million) Exhibit 67: Data Table on Germany - Market size and forecast 2021-2026 ($ million) Exhibit 68: Chart on Germany - Year-over-year growth 2021-2026 (%) Exhibit 69: Data Table on Germany - Year-over-year growth 2021-2026 (%) 7.9 China - Market size and forecast 2021-2026 Exhibit 70: Chart on China - Market size and forecast 2021-2026 ($ million) Exhibit 71: Data Table on China - Market size and forecast 2021-2026 ($ million) Exhibit 72: Chart on China - Year-over-year growth 2021-2026 (%) Exhibit 73: Data Table on China - Year-over-year growth 2021-2026 (%) 7.10 UK - Market size and forecast 2021-2026 Exhibit 74: Chart on UK - Market size and forecast 2021-2026 ($ million) Exhibit 75: Data Table on UK - Market size and forecast 2021-2026 ($ million) Exhibit 76: Chart on UK - Year-over-year growth 2021-2026 (%) Exhibit 77: Data Table on UK - Year-over-year growth 2021-2026 (%) 7.11 Canada - Market size and forecast 2021-2026 Exhibit 78: Chart on Canada - Market size and forecast 2021-2026 ($ million) Exhibit 79: Data Table on Canada - Market size and forecast 2021-2026 ($ million) Exhibit 80: Chart on Canada - Year-over-year growth 2021-2026 (%) Exhibit 81: Data Table on Canada - Year-over-year growth 2021-2026 (%) 7.12 Market opportunity by geography Exhibit 82: Market opportunity by geography ($ million) 8 Drivers, Challenges, and Trends 8.1 Market drivers 8.2 Market challenges 8.3 Impact of drivers and challenges Exhibit 83: Impact of drivers and challenges in 2021 and 2026 8.4 Market trends 9 Vendor Landscape 9.1 Overview 9.2 Vendor landscape Exhibit 84: Overview on Criticality of inputs and Factors of differentiation 9.3 Landscape disruption Exhibit 85: Overview on factors of disruption 9.4 Industry risks Exhibit 86: Impact of key risks on business 10 Vendor Analysis 10.1 Vendors covered Exhibit 87: Vendors covered 10.2 Market positioning of vendors Exhibit 88: Matrix on vendor position and classification 10.3 AbbVie Inc. Exhibit 89: AbbVie Inc. - Overview Exhibit 90: AbbVie Inc. - Product / Service Exhibit 91: AbbVie Inc. - Key offerings 10.4 Koninklijke DSM NV Exhibit 92: Koninklijke DSM NV - Overview Exhibit 93: Koninklijke DSM NV - Business segments Exhibit 94: Koninklijke DSM NV - Key news Exhibit 95: Koninklijke DSM NV - Key offerings Exhibit 96: Koninklijke DSM NV - Segment focus 10.5 Lannett Co. Inc. Exhibit 97: Lannett Co. Inc. - Overview Exhibit 98: Lannett Co. Inc. - Product / Service Exhibit 99: Lannett Co. Inc. - Key news Exhibit 100: Lannett Co. Inc. - Key offerings 10.6 Merck and Co. Inc. Exhibit 101: Merck and Co. Inc. - Overview Exhibit 102: Merck and Co. Inc. - Business segments Exhibit 103: Merck and Co. Inc. - Key news Exhibit 104: Merck and Co. Inc. - Key offerings Exhibit 105: Merck and Co. Inc. - Segment focus 10.7 Novartis AG Exhibit 106: Novartis AG - Overview Exhibit 107: Novartis AG - Business segments Exhibit 108: Novartis AG - Key offerings Exhibit 109: Novartis AG - Segment focus 10.8 Organon and Co. Exhibit 110: Organon and Co. - Overview Exhibit 111: Organon and Co. - Product / Service Exhibit 112: Organon and Co. - Key offerings 10.9 Perrigo Co. Plc Exhibit 113: Perrigo Co. Plc - Overview Exhibit 114: Perrigo Co. Plc - Business segments Exhibit 115: Perrigo Co. Plc - Key offerings Exhibit 116: Perrigo Co. Plc - Segment focus 10.10 Pfizer Inc. Exhibit 117: Pfizer Inc. - Overview Exhibit 118: Pfizer Inc. - Product / Service Exhibit 119: Pfizer Inc. - Key news Exhibit 120: Pfizer Inc. - Key offerings 10.11 ProThera Biologics Inc. Exhibit 121: ProThera Biologics Inc. - Overview Exhibit 122: ProThera Biologics Inc. - Product / Service Exhibit 123: ProThera Biologics Inc. - Key offerings 10.12 Sanofi Exhibit 124: Sanofi - Overview Exhibit 125: Sanofi - Business segments Exhibit 126: Sanofi - Key news Exhibit 127: Sanofi - Key offerings Exhibit 128: Sanofi - Segment focus 11 Appendix 11.1 Scope of the report 11.2 Inclusions and exclusions checklist Exhibit 129: Inclusions checklist Exhibit 130: Exclusions checklist 11.3 Currency conversion rates for US$ Exhibit 131: Currency conversion rates for US$ 11.4 Research methodology Exhibit 132: Research methodology Exhibit 133: Validation techniques employed for market sizing Exhibit 134: Information sources 11.5 List of abbreviations Exhibit 135: List of abbreviations About Us Technavio is a leading global technology research and advisory company. Their research and analysis focus on emerging market trends and provide actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions. With over 500 specialized analysts, Technavio's report library consists of more than 17,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavio's comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios. Contact Technavio Research Jesse Maida Media & Marketing Executive US: +1 844 364 1100 UK: +44 203 893 3200 Email: [email protected] Website: SOURCE Technavio