更新于：2024-12-05
Demethylcantharidin
去甲斑蝥素
更新于：2024-12-05
概要
基本信息
结构
分子式C8H8O4 |
InChIKeyJAABVEXCGCXWRR-FBXFSONDSA-N |
CAS号29745-04-8 |
关联
2
项与 去甲斑蝥素 相关的临床试验Phase I Clinical Study for Evaluation of Pharmacokinetic, Safety, Tolerance of Norcantharidin Lipid Microsphere for Injection in Patients With Solid Tumor
去甲斑蝥素脂质微球注射液在实体瘤患者中的安全性、耐受性、药代动力学Ⅰ期临床研究
100 项与 去甲斑蝥素 相关的临床结果
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100 项与 去甲斑蝥素 相关的转化医学
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100 项与 去甲斑蝥素 相关的专利（医药）
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27
项与 去甲斑蝥素 相关的文献（医药）2024-12-01JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
A tumor-pH-responsive phthalocyanine as activatable type I photosensitizer for improved photodynamic immunotherapy
Article
作者: Wang, Chao ; Li, Xingshu ; Zhang, Ling ; Sun, Hong-Jie ; Que, Rong-Bin ; Ke, Ting-Ting ; Huang, Jian-Dong ; Xie, Wei ; Ke, Mei-Rong ; Zheng, Bi-Yuan
The development of a simple drug formulation capable of achieving both activatable type I photoreaction and tumor-responsive release of immunomodulator is crucial for advancing photodynamic immunotherapy (PDIT). Herein, we present a nanostructured photosensitizer (NP5) that is activated by the acidic tumor microenvironment to produce type I reactive oxygen species (ROS) under light irradiation and release the immunomodulator demethylcantharidin (DMC) for PDIT. The NP5 is formed by self-assembly of a versatile phthalocyanine molecule which is composed of DMC and phthalocyanine linked via a pH-responsive amide bond. NP5 produces minimal ROS under light irradiation at the condition of pH 7.4. However, NP5 can release DMC at the condition of pH 6.5 and concurrently trigger type I photoreactions. The results of in vivo experiments indicate that NP5-mediated PDIT induce the increase of cytotoxic T lymphocytes and decrease of regulatory T lymphocytes, which can effectively inhibit the bilateral tumor growth. This work is anticipated to serve as a reference for the development of innovative agents for precise PDIT of hypoxic tumors.
2024-08-01Chemical Biology & Drug Design
Correction to “Nanoemulsion Based Lipid Nanoparticles for Effective Demethylcantharidin Delivery to Cure Liver Cancer”
2024-07-01Chemical Biology & Drug Design
Nanoemulsion based lipid nanoparticles for effective demethylcantharidin delivery to cure liver cancer
Article
作者: Deng, Mengyue ; Yan, Zijun ; Yu, Ting ; Wu, Xiaoping ; Zhang, Yuehui ; Wei, Panpan ; Xia, Die ; Ding, Yuzhen ; Chen, Tong ; Zhang, Liangming ; Su, Ning
Abstract:
Demethylcantharidin (DEM) is a widely used antitumor drug; however, its poor tumor targeting and serious organotoxicity limit its application. The aim of this study was to develop a new drug delivery system for efficient delivery of DEM. Nanoemulsion based lipid nanoparticles containing demethylcantharidin (DNLNs) were prepared by loading nanoemulsions into lipid nanoparticles. The cells proliferation, apoptosis, cycle, and uptake were investigated by Cell counting kit‐8 (CCK‐8), flow cytometry, and in situ fluorescence assays, respectively. Then, we established the H22 tumor‐bearing mouse model to evaluate the antitumor efficacy of DNLNs and further studied its organ toxicity and distribution. DNLNs significantly inhibited the proliferation and promoted apoptosis of H22 cells, and H22 cells could take up more DNLNs. Compared with DEM, DNLNs had certain tumor‐targeting properties, and the tumor inhibition rate increased by 23.24%. Moreover, DNLNs can increase white blood cell count and reduce organ toxicity. This study paves the way for nanoemulsion‐based lipid nanoparticle (NLNs)‐efficient DEM delivery to treat liver cancer.
1
项与 去甲斑蝥素 相关的新闻（医药）2024-09-20
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100 项与 去甲斑蝥素 相关的药物交易
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