作者: Walczak, Michal J ; Thomä, Nicolas H ; Petzold, Georg
A review.Proteolysis-targeting chimera (PROTACs) are synthetic mols. that recruit neo-substrate proteins to an E3 ubiquitin ligase for ubiquitination and subsequent degradationStructural insight into the VHL-MZ1-BRD4 complex reveals how the rationally designed MZ1-PROTAC mol. mediates degradation of an unnatural protein substrate.